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Tchem
EIF4E
Eukaryotic translation initiation factor 4E

Protein Summary
Description
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap. The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Altern ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280892
  • ENSP00000280892
  • ENSG00000151247
  • ENST00000450253
  • ENSP00000389624
  • ENST00000505992
  • ENSP00000425561

Symbol
  • EIF4EL1
  • EIF4F
  • CBP
  • EIF4F
  • AUTS19
  • EIF4E1
  • eIF-4E
  • EIF4EL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.97
interacting protein
0.92
microRNA
0.84
transcription factor binding site profile
0.84
biological process
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1618.13   (req: < 5)
Gene RIFs: 284   (req: <= 3)
Antibodies: 885   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1618.13   (req: >= 5)
Gene RIFs: 284   (req: > 3)
Antibodies: 885   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 19
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1