| Tchem | eIF-2-alpha kinase GCN2 |
This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Amino Acid Metabolism, Inborn Errors | 13 | 0.0 | 0.0 |
| Hair Diseases | 3 | 0.0 | 0.0 |
| Hypertension, Pulmonary | 37 | 0.0 | 0.0 |
| Immune System Diseases | 4 | 0.0 | 0.0 |
| Muscular Diseases | 27 | 0.0 | 0.0 |
| Pulmonary Veno-Occlusive Disease | 2 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| osteosarcoma | 7950 | 6.8e-07 |
| ovarian cancer | 8520 | 9.6e-05 |
| cystic fibrosis | 1696 | 1.6e-04 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.7e-04 |
| glioblastoma | 5792 | 2.5e-04 |
| subependymal giant cell astrocytoma | 2287 | 5.4e-03 |
| ileal Crohn's disease | 9 | 4.3e-02 |
| Rheumatoid arthritis | 1191 | 4.6e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Globe disease | 67 | 0.0 | 0.9 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Pulmonary venoocclusive disease | 3 | 6.972 | 3.5 |
| Primary pulmonary hypertension | 14 | 0.0 | 5.0 |
| Disease | log2 FC | p |
|---|---|---|
| atypical teratoid / rhabdoid tumor | 1.100 | 1.7e-04 |
| cystic fibrosis | -1.290 | 1.6e-04 |
| glioblastoma | 1.200 | 2.5e-04 |
| ileal Crohn's disease | -1.345 | 4.3e-02 |
| osteosarcoma | -1.779 | 6.8e-07 |
| ovarian cancer | -1.300 | 9.6e-05 |
| Rheumatoid arthritis | 1.100 | 4.6e-02 |
| subependymal giant cell astrocytoma | 1.509 | 5.4e-03 |
CHEMBL386051
pKd 7.59
CHEMBL388978
pKd 7.80
CHEMBL3407850
pIC50 7.92
CHEMBL3407851
pIC50 8.00
CHEMBL3407849
pIC50 8.30
CHEMBL603469
pKd 8.39
CHEMBL475251
pKd 8.48
MAGGRGAPGRGRDEPPESYPQRQDHELQALEAIYGADFQDLRPDACGPVKEPPEINLVLYPQGLTGEEVY 1 - 70 VKVDLRVKCPPTYPDVVPEIELKNAKGLSNESVNLLKSRLEELAKKHCGEVMIFELAYHVQSFLSEHNKP 71 - 140 PPKSFHEEMLERRAQEEQQRLLEAKRKEEQEQREILHEIQRRKEEIKEEKKRKEMAKQERLEIASLSNQD 141 - 210 HTSKKDPGGHRTAAILHGGSPDFVGNGKHRANSSGRSRRERQYSVCNSEDSPGSCEILYFNMGSPDQLMV 211 - 280 HKGKCIGSDEQLGKLVYNALETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSL 281 - 350 VKLSHPNVVRYLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNS 351 - 420 VVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDNALPYKTGKKGDVWRLGLLLLS 421 - 490 LSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFINPQPKMPLVEQSPEDSEGQDY 491 - 560 VETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQF 561 - 630 RRIKGEVTLLSRLHHENIVRYYNAWIERHERPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAA 631 - 700 PPPILSSSVEWSTSGERSASARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKS 701 - 770 QNQDEDCNEKNGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIH 771 - 840 EKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTGMVGTALYVSP 841 - 910 EVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSPKFPEDFDDGEHAKQKSVISW 911 - 980 LLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHTLTNVDGKAYRTMMAQIFSQRISPAIDYTYDSD 981 - 1050 ILKGNFSIRTAKMQQHVCETIIRIFKRHGAVQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRI 1051 - 1120 PFARYVARNNILNLKRYCIERVFRPRKLDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPA 1121 - 1190 LQERNYSIYLNHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKF 1191 - 1260 IEQKGDLQDLMPTINSLIKQKTGIAQLVKYGLKDLEEVVGLLKKLGIKLQVLINLGLVYKVQQHNGIIFQ 1261 - 1330 FVAFIKRRQRAVPEILAAGGRYDLLIPQFRGPQALGPVPTAIGVSIAIDKISAAVLNMEESVTISSCDLL 1331 - 1400 VVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQEYCRHHEITYVALVSDKEGSHVKVKSFEKE 1401 - 1470 RQTEKRVLETELVDHVLQKLRTKVTDERNGREASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPE 1471 - 1540 KLSASTRRRYETQVQTRLQTSLANLHQKSSEIEILAVDLPKETILQFLSLEWDADEQAFNTTVKQLLSRL 1541 - 1610 PKQRYLKLVCDEIYNIKVEKKVSVLFLYSYRDDYYRILF 1611 - 1649 //
