Tbio EFEMP1 EGF-containing fibulin-like extracellular matrix protein 1

Protein Summary

Description

Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth. This gene encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy. Alternatively spliced transcript variants that encode the same protein have been described.[provided by RefSeq, Nov 2009]

Uniprot Accession IDs

• Q12805
• A8K3I4
• B4DW75
• D6W5D2
• Q541U7

Gene Name

• EFEMP1

Ensembl ID

• ENST00000355426
• ENSP00000347596
• ENSG00000115380
• ENST00000394555
• ENSP00000378058

Symbol

• FBLN3
• FBNL
• DHRD
• DRAD
• FBNL
• MLVT
• MTLV
• S1-5
• FBLN3
• FIBL-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.99
viral protein	0.93
protein domain	0.92
PubMedID	0.89
virus	0.89

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Egf-containing Fibulin-like Extracellular Matrix Protein 1

Protein / Extracellular Matrix Protein / Extracellular Matrix Structural Protein / Egf-containing Fibulin-like Extracellular Matrix Protein 1

Protein / Extracellular Matrix Protein / Extracellular Matrix Glycoprotein / Egf-containing Fibulin-like Extracellular Matrix Protein 1

Protein / Cell Adhesion Molecule / Egf-containing Fibulin-like Extracellular Matrix Protein 1

Protein / Calcium-binding Protein / Annexin / Egf-containing Fibulin-like Extracellular Matrix Protein 1

DTO Classes

Protein / Extracellular Structure / Extracellular Matrix Glycoprotein / Egf-containing Fibulin-like Extracellular Matrix Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 221.32   (req: < 5)

Gene RIFs: 118   (req: <= 3)

Antibodies: 358   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 221.32   (req: >= 5)

Gene RIFs: 118   (req: > 3)

Antibodies: 358   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0