| Tbio | Endothelin-1 |
Endothelins are endothelium-derived vasoconstrictor peptides.
This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 8.9e-21 |
| non-small cell lung cancer | 2890 | 8.5e-15 |
| lung adenocarcinoma | 2716 | 5.3e-11 |
| glioblastoma | 5792 | 7.5e-07 |
| Astrocytoma, Pilocytic | 3081 | 9.1e-07 |
| ulcerative colitis | 1819 | 2.9e-05 |
| breast carcinoma | 1638 | 3.7e-05 |
| malignant mesothelioma | 3232 | 3.9e-05 |
| group 3 medulloblastoma | 4104 | 9.1e-05 |
| medulloblastoma, large-cell | 6241 | 2.2e-04 |
| ovarian cancer | 8520 | 2.2e-04 |
| ependymoma | 4679 | 4.3e-04 |
| lung cancer | 4740 | 6.1e-04 |
| ductal carcinoma in situ | 1745 | 1.4e-03 |
| adult high grade glioma | 3801 | 9.5e-03 |
| spina bifida | 1074 | 2.7e-02 |
| Breast cancer | 3578 | 3.9e-02 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 4.2e-02 |
| primitive neuroectodermal tumor | 3035 | 4.4e-02 |
| invasive ductal carcinoma | 2951 | 4.4e-02 |
| Disease | Target Count |
|---|---|
| AURICULOCONDYLAR SYNDROME 3 | 1 |
| QUESTION MARK EARS, ISOLATED | 1 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.200 | 9.5e-03 |
| Astrocytoma, Pilocytic | -1.500 | 9.1e-07 |
| Breast cancer | -3.000 | 3.9e-02 |
| breast carcinoma | -1.700 | 3.7e-05 |
| ductal carcinoma in situ | -1.100 | 1.4e-03 |
| ependymoma | -1.200 | 4.3e-04 |
| glioblastoma | -1.300 | 7.5e-07 |
| group 3 medulloblastoma | -1.800 | 9.1e-05 |
| invasive ductal carcinoma | -1.101 | 4.4e-02 |
| lung adenocarcinoma | -2.000 | 5.3e-11 |
| lung cancer | -1.500 | 6.1e-04 |
| lung carcinoma | -3.700 | 8.9e-21 |
| malignant mesothelioma | 1.100 | 3.9e-05 |
| medulloblastoma, large-cell | -1.700 | 2.2e-04 |
| non-small cell lung cancer | -2.068 | 8.5e-15 |
| ovarian cancer | 1.200 | 2.2e-04 |
| pancreatic ductal adenocarcinoma liver m... | 1.320 | 4.2e-02 |
| primitive neuroectodermal tumor | -1.100 | 4.4e-02 |
| spina bifida | -1.225 | 2.7e-02 |
| ulcerative colitis | -1.200 | 2.9e-05 |
