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Tbio
DZIP3
E3 ubiquitin-protein ligase DZIP3

Protein Summary
Description
E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361582
  • ENSP00000355028
  • ENSG00000198919
  • ENST00000463306
  • ENSP00000419981
  • ENST00000495008
  • ENSP00000418871

Symbol
  • KIAA0675
  • UURF2
  • PPP1R66
  • hRUL138
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
molecular function
0.79
transcription factor perturbation
0.74
cell line
0.72
tissue sample
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.62   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.62   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0