Tchem | Dual specificity tyrosine-phosphorylation-regulated kinase 3 |
This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Comments
Disease | Target Count | P-value |
---|---|---|
posterior fossa group B ependymoma | 416 | 6.4e-08 |
malignant mesothelioma | 3232 | 9.3e-07 |
lung adenocarcinoma | 2716 | 4.2e-06 |
lung cancer | 4740 | 6.8e-04 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Down syndrome | 499 | 3.373 | 1.7 |
Disease | log2 FC | p |
---|---|---|
lung adenocarcinoma | 1.100 | 4.2e-06 |
lung cancer | -1.200 | 6.8e-04 |
malignant mesothelioma | -2.200 | 9.3e-07 |
posterior fossa group B ependymoma | 1.200 | 6.4e-08 |
Species | Source | Disease |
---|---|---|
Inparanoid OMA | ||
Inparanoid OMA | ||
Inparanoid OMA | ||
Inparanoid OMA | ||
Inparanoid OMA | ||
Inparanoid OMA | ||
Inparanoid OMA | ||
Inparanoid OMA | ||
Inparanoid OMA | ||
Inparanoid OMA |
CHEMBL3730504
pIC50 8.00
CHEMBL3728543
pIC50 9.00
CHEMBL3728359
pIC50 9.00
compound 1a [PMID: 24900749]
pIC50 7.15
compound 3b [PMID: 23454515]
pIC50 6.74
kinase inhibitor 2 [PMID: 30199702]
pIC50 6.42
MGGTARGPGRKDAGPPGAGLPPQQRRLGDGVYDTFMMIDETKCPPCSNVLCNPSEPPPPRRLNMTTEQFT 1 - 70 GDHTQHFLDGGEMKVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKSSDCLNTVKSNSSSKAPKVVP 71 - 140 LTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYE 141 - 210 VLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTF 211 - 280 RNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSS 281 - 350 TKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLAC 351 - 420 MMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGC 421 - 490 DDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGSKLPPVVG 491 - 560 IANKLKANLMSETNGSIPLCSVLPKLIS 561 - 588 //