Tchem DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B

Protein Summary

Description

Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC). This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Uniprot Accession IDs

• Q9Y463
• O75258
• O75788
• O75789

Gene Name

• DYRK1B

Ensembl ID

• ENST00000323039
• ENSP00000312789
• ENSG00000105204
• ENST00000348817
• ENSP00000221803
• ENST00000430012
• ENSP00000403182
• ENST00000593685
• ENSP00000469863
• ENST00000597639
• ENSP00000472941
• ENST00000625388
• ENSP00000486839
• ENSG00000281320
• ENST00000625438
• ENSP00000487313
• ENST00000625757
• ENSP00000485915
• ENST00000627034
• ENSP00000487539
• ENST00000631090
• ENSP00000486377

Symbol

• MIRK
• MIRK
• AOMS3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.97
small molecule	0.92
gene perturbation	0.74
protein domain	0.73
kinase perturbation	0.66

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Tyrosine Protein Kinase / Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1b

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1b

DTO Classes

Protein / Kinase / Protein Kinase / Cmgc Group / Dyrk Family / Dyrk1 Subfamily / Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.95   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 336   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.95   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 336   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 116

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0