| Tbio | Dynein light chain Tctex-type 3 |
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity).
This gene encodes a member of a subclass of dynein light chains. The encoded protein homodimerizes and forms the light chain component of the cytoplasmic dynein motor protein complex. This protein may be important for binding dynein to specific cargos including the spindle checkpoint protein BUB3. This protein may also function independently of dynein as a transcriptional modulator. Pseudogenes of this gene are found on chromosomes 2 and 20.[provided by RefSeq, Mar 2010]
This gene encodes a member of a subclass of dynein light chains. The encoded protein homodimerizes and forms the light chain component of the cytoplasmic dynein motor protein complex. This protein may be important for binding dynein to specific cargos including the spindle checkpoint protein BUB3. This protein may also function independently of dynein as a transcriptional modulator. Pseudogenes of this gene are found on chromosomes 2 and 20.[provided by RefSeq, Mar 2010]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| malignant mesothelioma | 3232 | 2.8e-09 |
| atypical teratoid / rhabdoid tumor | 5112 | 2.8e-06 |
| ovarian cancer | 8520 | 2.9e-05 |
| medulloblastoma, large-cell | 6241 | 5.0e-05 |
| acute quadriplegic myopathy | 1158 | 6.5e-05 |
| astrocytic glioma | 2597 | 2.1e-03 |
| dermatomyositis | 966 | 3.3e-03 |
| primitive neuroectodermal tumor | 3035 | 5.6e-03 |
| group 3 medulloblastoma | 4104 | 7.5e-03 |
| ependymoma | 4679 | 1.2e-02 |
| progressive supranuclear palsy | 676 | 1.6e-02 |
| oligodendroglioma | 2850 | 1.7e-02 |
| Multiple myeloma | 1332 | 4.5e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Ornithine carbamoyltransferase deficiency | 12 | 3.873 | 1.9 |
| Retinitis Pigmentosa | 226 | 3.479 | 1.7 |
| Salivary gland adenoid cystic carcinoma | 6 | 3.313 | 1.7 |
| Disease | log2 FC | p |
|---|---|---|
| acute quadriplegic myopathy | 1.146 | 6.5e-05 |
| astrocytic glioma | -2.800 | 2.1e-03 |
| atypical teratoid / rhabdoid tumor | -1.600 | 2.8e-06 |
| dermatomyositis | 1.200 | 3.3e-03 |
| ependymoma | -2.600 | 1.2e-02 |
| group 3 medulloblastoma | -1.100 | 7.5e-03 |
| malignant mesothelioma | -3.500 | 2.8e-09 |
| medulloblastoma, large-cell | -1.900 | 5.0e-05 |
| Multiple myeloma | 1.324 | 4.5e-02 |
| oligodendroglioma | -3.000 | 1.7e-02 |
| ovarian cancer | -1.900 | 2.9e-05 |
| primitive neuroectodermal tumor | -1.700 | 5.6e-03 |
| progressive supranuclear palsy | -1.100 | 1.6e-02 |
