| Tbio | Dynein light chain Tctex-type 3 |
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity).
This gene encodes a member of a subclass of dynein light chains. The encoded protein homodimerizes and forms the light chain component of the cytoplasmic dynein motor protein complex. This protein may be important for binding dynein to specific cargos including the spindle checkpoint protein BUB3. This protein may also function independently of dynein as a transcriptional modulator. Pseudogenes of this gene are found on chromosomes 2 and 20.[provided by RefSeq, Mar 2010]
This gene encodes a member of a subclass of dynein light chains. The encoded protein homodimerizes and forms the light chain component of the cytoplasmic dynein motor protein complex. This protein may be important for binding dynein to specific cargos including the spindle checkpoint protein BUB3. This protein may also function independently of dynein as a transcriptional modulator. Pseudogenes of this gene are found on chromosomes 2 and 20.[provided by RefSeq, Mar 2010]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| malignant mesothelioma | 3163 | 2.8e-09 |
| atypical teratoid / rhabdoid tumor | 4369 | 2.8e-06 |
| group 4 medulloblastoma | 1875 | 6.2e-06 |
| ovarian cancer | 8491 | 2.9e-05 |
| medulloblastoma, large-cell | 6234 | 5.0e-05 |
| acute quadriplegic myopathy | 1157 | 6.5e-05 |
| astrocytic glioma | 2241 | 2.1e-03 |
| dermatomyositis | 966 | 3.3e-03 |
| primitive neuroectodermal tumor | 3031 | 5.6e-03 |
| ependymoma | 2514 | 1.2e-02 |
| progressive supranuclear palsy | 674 | 1.6e-02 |
| oligodendroglioma | 2849 | 1.7e-02 |
| Multiple myeloma | 1327 | 4.5e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Ornithine carbamoyltransferase deficiency | 13 | 3.965 | 2.0 |
| Salivary gland adenoid cystic carcinoma | 6 | 3.378 | 1.7 |
| Retinitis pigmentosa | 156 | 3.279 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| Multiple myeloma | 1.324 | 4.5e-02 |
| malignant mesothelioma | -3.500 | 2.8e-09 |
| astrocytic glioma | -2.800 | 2.1e-03 |
| ependymoma | -2.600 | 1.2e-02 |
| oligodendroglioma | -3.000 | 1.7e-02 |
| group 4 medulloblastoma | -1.600 | 6.2e-06 |
| atypical teratoid / rhabdoid tumor | -1.600 | 2.8e-06 |
| medulloblastoma, large-cell | -1.900 | 5.0e-05 |
| primitive neuroectodermal tumor | -1.700 | 5.6e-03 |
| acute quadriplegic myopathy | 1.146 | 6.5e-05 |
| progressive supranuclear palsy | -1.100 | 1.6e-02 |
| ovarian cancer | -1.900 | 2.9e-05 |
| dermatomyositis | 1.200 | 3.3e-03 |
| PMID | Year | Title | |
|---|---|---|---|
| 27173435 | 2016 | An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. | |
| 25416956 | 2014 | A proteome-scale map of the human interactome network. | |
| 21166973 | 2011 | Identification of the dynein light chains required for human papillomavirus infection. | |
| 20668116 | 2010 | Identification of binding domains in the herpes simplex virus type 1 small capsid protein pUL35 (VP26). | |
| 18029348 | 2008 | Toward a confocal subcellular atlas of the human proteome. | |
| 17676955 | 2007 | Dynein modifiers in C. elegans: light chains suppress conditional heavy chain mutants. | |
| 17289665 | 2007 | The DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3. | |
| 16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. | |
| 16189514 | 2005 | Towards a proteome-scale map of the human protein-protein interaction network. | |
| 16079286 | 2005 | Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway. | |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | |
| 15117959 | 2004 | Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport. | |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | |
| 11746667 | 2001 | Light chains of mammalian cytoplasmic dynein: identification and characterization of a family of LC8 light chains. | |
| 11425878 | 2001 | Cytoplasmic dynein regulation by subunit heterogeneity and its role in apical transport. | |
| 9790665 | 1998 | Cytoplasmic dynein contains a family of differentially expressed light chains. | |
| 8004092 | 1994 | Identification of a gene from Xp21 with similarity to the tctex-1 gene of the murine t complex. |
