| Tbio | Dynein light chain roadblock-type 1 |
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in the regulation of actin modulating proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 12 and 18. [provided by RefSeq, Aug 2013]
This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in the regulation of actin modulating proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 12 and 18. [provided by RefSeq, Aug 2013]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8297 | 4.0e-06 |
| psoriasis | 6514 | 9.8e-05 |
| osteosarcoma | 7766 | 3.4e-04 |
| Multiple myeloma | 1296 | 5.1e-04 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3204 | 2.2e-03 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Carrion's disease | 6 | 3.422 | 1.7 |
| Blastomycosis | 12 | 3.032 | 1.5 |
| adult-onset autosomal dominant demyelinating leukodystrophy | 10 | 3.025 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| intraductal papillary-mucinous neoplasm ... | 1.300 | 2.2e-03 |
| Multiple myeloma | 1.037 | 5.1e-04 |
| osteosarcoma | -1.389 | 3.4e-04 |
| ovarian cancer | 2.100 | 4.0e-06 |
| psoriasis | -1.400 | 9.8e-05 |
