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Tbio
DUSP23
Dual specificity protein phosphatase 23

Protein Summary
Description
Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368107
  • ENSP00000357087
  • ENSG00000158716
  • ENST00000368108
  • ENSP00000357088
  • ENST00000368109
  • ENSP00000357089

Symbol
  • LDP3
  • VHZ
  • VHZ
  • LDP3
  • MOSP
  • LDP-3
  • DUSP25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.78
virus perturbation
0.72
transcription factor binding site profile
0.69
protein domain
0.58
transcription factor
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.99   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.99   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0