You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
DUSP22
Dual specificity protein phosphatase 22

Protein Summary
Description
Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344450
  • ENSP00000345281
  • ENSG00000112679
  • ENST00000419235
  • ENSP00000397459

Symbol
  • JSP1
  • LMWDSP2
  • MKPX
  • VHX
  • JKAP
  • JSP1
  • MKPX
  • JSP-1
  • MKP-x
  • LMWDSP2
  • LMW-DSP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
biological process
0.87
protein domain
0.85
kinase perturbation
0.84
transcription factor
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.52   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 290   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.52   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 290   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0