Tbio DUSP15 Dual specificity protein phosphatase 15

Protein Summary

Description

May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 (PubMed:22792334). Isoform 3: May play a role in the regulation of oligodendrocyte differentiation. May play a role in the regulation of myelin formation (By similarity). Involved in the regulation of Erk1/2 phosphorylation in Schwann cells; the signaling may be linked to the regulation of myelination (By similarity). The protein encoded by this gene has both protein-tyrosine phophatase activity and serine/threonine-specific phosphatase activity, and therefore is known as a dual specificity phosphatase. This protein may function in the differentiation of oligodendrocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• Q9H1R2
• A6NH79
• A8MVC8
• Q5QP62
• Q5QP63
• Q5QP65
• Q6PGN7
• Q8N826
• Q9BX24

Gene Name

• DUSP15

Ensembl ID

• ENST00000278979
• ENSP00000278979
• ENSG00000149599
• ENST00000339738
• ENSP00000341658
• ENST00000375966
• ENSP00000365133
• ENST00000398083
• ENSP00000381157
• ENST00000398084
• ENSP00000381158
• ENST00000486996
• ENSP00000419818

Symbol

• C20orf57
• VHY
• VHY
• C20orf57

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
gene perturbation	0.68
cell type or tissue	0.65
transcription factor	0.62
kinase perturbation	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 206   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0