Property Summary

NCBI Gene PubMed Count 14
PubMed Score 29.87
PubTator Score 10.87

Knowledge Summary


No data available


  Disease (3)

Disease Target Count
Peripheral Neuropathy 303
Disease Target Count P-value
malignant mesothelioma 3163 4.2e-08
acute quadriplegic myopathy 1157 3.4e-05
Disease Target Count Z-score Confidence
Vaccinia 37 3.655 1.8


  Differential Expression (2)

Disease log2 FC p
malignant mesothelioma 3.700 4.2e-08
acute quadriplegic myopathy -1.066 3.4e-05

Gene RIF (4)

21360282 data suggest an important role for DUSP13B in protection from external stress during spermatogenesis
17044055 Here, we report the crystal structure of human TMDP at a resolution of 2.4 A. In spite of high sequence similarity with other DSPs, the crystal structure of TMDP shows distinct structural motifs and surface propertie
16385451 Observational study of gene-disease association. (HuGE Navigator)
15252030 identified a gene on chromosome 10q22.2 using alternative ORFs to encode two distinct DSPs: the testis and skeletal muscle-specific TMDP and a novel muscle-restricted DSP(MDSP)

AA Sequence


Text Mined References (15)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
24531476 2014 The family-wide structure and function of human dual-specificity protein phosphatases.
21360282 2011 DUSP13B/TMDP inhibits stress-activated MAPKs and suppresses AP-1-dependent gene expression.
20358250 2010 Positive regulation of apoptosis signal-regulating kinase 1 by dual-specificity phosphatase 13A.
17044055 2007 Crystal structure of human TMDP, a testis-specific dual specificity protein phosphatase: implications for substrate specificity.
16385451 2006 A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
16189514 2005 Towards a proteome-scale map of the human protein-protein interaction network.
15761153 2005 High-throughput mapping of a dynamic signaling network in mammalian cells.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15252030 2004 Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2.
15164054 2004 The DNA sequence and comparative analysis of human chromosome 10.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
10585869 1999 Molecular cloning and characterization of a novel dual-specificity protein phosphatase possibly involved in spermatogenesis.