DSTYK
Dual serine/threonine and tyrosine protein kinase
Protein Summary
Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540). This gene encodes a dual serine/threonine and tyrosine protein kinase which is expressed in multiple tissues. It is thought to function as a regulator of cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
- ENST00000367161
- ENSP00000356129
- ENSG00000133059
- ENST00000367162
- ENSP00000356130
- ENST00000615388
- ENSP00000478016
- KIAA0472
- RIP5
- RIPK5
- SGK496
- RIP5
- RIPK5
- SPG23
- CAKUT1
- DustyPK
- HDCMD38P
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.95 | ||
molecular function | 0.93 | ||
transcription factor binding site profile | 0.93 | ||
microRNA | 0.85 | ||
transcription factor | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13.21 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 166 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13.21 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 166 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0