Property Summary

NCBI Gene PubMed Count 26
PubMed Score 20.84
PubTator Score 15.18

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Expression

  Differential Expression (2)

Disease log2 FC p
Breast cancer 3.200 2.8e-02
ovarian cancer 2.100 4.3e-04

Protein-protein Interaction (9)

Gene RIF (11)

PMID Text
26691508 Dpy30 role in cellular reprogramming and its interactions with Set1 complex
26147337 results indicate that DPY30 has critical roles in the proliferation, migration, and invasion of gastric cancer cells, and suggest DPY30 might be a therapeutic target in gastric cancer
25561738 these results form the basis for understanding how WRAD(DRY-30) differentially regulates SET1 family complexes in vivo.
25542209 Based on our structural data and cross-linking results, we suggest that Dpy30 may regulate H3K4 methylation according to its copy number in COMPASS
25139354 The DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cells.
24690193 A deletion mutation and reduced DPY30 expression in a Spastic Paraplegia type 4 Japanese family.
23872946 DPY30 regulates pathways in cellular senescence through ID protein expression.
22231628 determination of the minimum motif of Ash2L that is required for DPY30 interaction; a structural model for the Ash2L-DPY30 interaction
20857310 First report of SPG4 associated with partial deletions of both the SPAST and DPY30 genes. The partial heterozygous deletion of DPY30 could modify the phenotypic expression of SPG4 patients with this pedigree.
19481096 The DPY-30 C-terminal domain structure, harboring the conserved DPY-30 motif, is composed of two alpha-helices linked by a sharp loop and forms a typical X-type four-helix bundle required for dimer formation.
17500065 hDPY-30 (dpy-30-like protein) binds ASH2L directly. The evolutionarily conserved hDPY-30, ASH2L, RBBP5 and WDR5 likely constitute a subcomplex that is shared by all human Set1-like HMT complexes.

AA Sequence

MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLA      1 - 70
VLAKERPPNPIEFLASYLLKNKAQFEDRN                                              71 - 99
//

Text Mined References (33)

PMID Year Title
26691508 2015 Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors.
26147337 2015 Roles of DPY30 in the Proliferation and Motility of Gastric Cancer Cells.
25561738 2015 Biochemical reconstitution and phylogenetic comparison of human SET1 family core complexes involved in histone methylation.
25542209 2015 Structural implications of Dpy30 oligomerization for MLL/SET1 COMPASS H3K4 trimethylation.
25416956 2014 A proteome-scale map of the human interactome network.
25139354 2014 The DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cells.
24690193 2014 Novel SPAST deletion and reduced DPY30 expression in a Spastic Paraplegia type 4 kindred.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24182552 2014 Novel gene variants predict serum levels of the cytokines IL-18 and IL-1ra in older adults.
23872946 2013 DPY30 regulates pathways in cellular senescence through ID protein expression.
23414517 2013 A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
22231628 2012 Structure of the SPRY domain of human Ash2L and its interactions with RbBP5 and DPY30.
21516116 2011 Next-generation sequencing to generate interactome datasets.
21335234 2011 Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains.
21269460 2011 Initial characterization of the human central proteome.
20857310 2011 Partial SPAST and DPY30 deletions in a Japanese spastic paraplegia type 4 family.
19651892 2009 A role of histone H3 lysine 4 methyltransferase components in endosomal trafficking.
19608861 2009 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19556245 2009 On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex.
19481096 2009 Crystal structure of the C-terminal domain of human DPY-30-like protein: A component of the histone methyltransferase complex.
19413330 2009 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
18838538 2008 Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
17500065 2007 PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.
16730941 2006 A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex.
16260194 2005 Characterization and crystallization of human DPY-30-like protein, an essential component of dosage compensation complex.
16189514 2005 Towards a proteome-scale map of the human protein-protein interaction network.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14992727 2004 Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11329013 2001 Creation of genome-wide protein expression libraries using random activation of gene expression.
10409428 1999 Gene expression in proliferating human erythroid cells.