Property Summary

NCBI Gene PubMed Count 17
PubMed Score 8.89
PubTator Score 4.23

Knowledge Summary


No data available


  Disease (2)

Disease Target Count P-value
osteosarcoma 7933 1.7e-11
non primary Sjogren syndrome sicca 840 2.5e-02
acute myeloid leukemia 785 3.1e-02
Disease Target Count Z-score Confidence
Embryonal carcinoma 11 3.389 1.7


  Differential Expression (3)

Disease log2 FC p
osteosarcoma -3.674 1.7e-11
non primary Sjogren syndrome sicca -1.200 2.5e-02
acute myeloid leukemia -2.500 3.1e-02

Gene RIF (5)

26687479 knockdown of PCGF1 results in reduced expression of DPPA4 and other subunits of the variant PRC1 complex at both mRNA and protein levels
23963736 Results identified a new family of pluripotency-related oncogenes consisting of DPPA2 and DPPA4.
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19913121 Observational study of gene-disease association. (HuGE Navigator)
18366076 Thsi study identifies DPPA4 and other genes as putative Sox2:Oct-3/4 target genes using a combination of in silico analysis and transcription-based assays.

AA Sequence

LEDNMLCPKCVHRNKVLIKSLQWE                                                  281 - 304

Text Mined References (19)

PMID Year Title
26687479 2015 The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.
25416956 2014 A proteome-scale map of the human interactome network.
23963736 2013 Identification of DPPA4 and DPPA2 as a novel family of pluripotency-related oncogenes.
23761726 2013 Interrogation of the platelet-derived growth factor receptor alpha locus and corneal astigmatism in Australians of Northern European ancestry: results of a genome-wide association study.
21900206 2011 A directed protein interaction network for investigating intracellular signal transduction.
21516116 2011 Next-generation sequencing to generate interactome datasets.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21348951 2011 Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
18366076 2008 Identification of DPPA4 and other genes as putative Sox2:Oct-3/4 target genes using a combination of in silico analysis and transcription-based assays.
16641997 2006 The DNA sequence, annotation and analysis of human chromosome 3.
16189514 2005 Towards a proteome-scale map of the human protein-protein interaction network.
16169070 2005 A human protein-protein interaction network: a resource for annotating the proteome.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12620990 2003 Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
8889549 1996 Generation and analysis of 280,000 human expressed sequence tags.