Tchem DPP7 Dipeptidyl peptidase 2

Protein Summary

Description

Plays an important role in the degradation of some oligopeptides. The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UHL4
• A8K7U7
• Q5VSF1
• Q969X4

Gene Name

• DPP7

Ensembl ID

• ENST00000371579
• ENSP00000360635
• ENSG00000176978

Symbol

• DPP2
• QPP
• QPP
• DPP2
• DPPII

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.91
cell type or tissue	0.8
histone modification site profile	0.79
disease perturbation	0.74
cellular component	0.69

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Serine Protease / Dipeptidyl Peptidase 2

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Dipeptidyl Peptidase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 306.23   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 259   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 306.23   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 259   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 236

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0