Protein Summary
Probable metalloprotease which hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4). DPEP2 belongs to the membrane-bound dipeptidase (EC 3.4.13.19) family. These enzymes hydrolyze a variety of dipeptides, including leukotriene D4, the beta-lactam ring of some antibiotics, and cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (Habib et al., 2003 [PubMed 12738806]).[supplied by OMIM, Mar 2008]
- ENST00000393847
- ENSP00000377430
- ENSG00000167261
- ENST00000572888
- ENSP00000458977
- ENST00000575203
- ENSP00000459375
- MBD2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
tissue sample | 0.64 | ||
cell type or tissue | 0.57 | ||
co-expressed gene | 0.57 | ||
molecular function | 0.53 | ||
cell line | 0.5 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.8 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 61 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.8 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 61 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0