Tbio DOCK8 Dedicator of cytokinesis protein 8

Protein Summary

Description

Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:28028151, PubMed:22461490). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (By similarity). Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780). This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• Q8NF50
• A2A350
• A2BDF2
• A4FU78
• B7ZLP0
• E9PH09
• Q3MV16
• Q5JPJ1
• Q8TEP1
• Q8WUY2
• Q9BYJ5
• Q9H1Q2
• Q9H1Q3
• Q9H308
• Q9H7P2

Gene Name

• DOCK8

Ensembl ID

• ENST00000432829
• ENSP00000394888
• ENSG00000107099
• ENST00000453981
• ENSP00000408464
• ENST00000469391
• ENSP00000419438

Symbol

• MRD2
• ZIR8
• HEL-205

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
transcription factor binding site profile	0.85
kinase perturbation	0.81
transcription factor perturbation	0.8
histone modification site profile	0.71

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Dedicator Of Cytokinesis Protein 8

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Dedicator Of Cytokinesis Protein 8

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 228.7   (req: < 5)

Gene RIFs: 69   (req: <= 3)

Antibodies: 245   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 228.7   (req: >= 5)

Gene RIFs: 69   (req: > 3)

Antibodies: 245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0