Property Summary

NCBI Gene PubMed Count 14
PubMed Score 3.92
PubTator Score 4.20

Knowledge Summary


No data available


  Differential Expression (6)

Disease log2 FC p
primary pancreatic ductal adenocarcinoma 1.573 4.1e-03
pancreatic cancer 1.200 1.9e-06
group 3 medulloblastoma 1.200 3.4e-03
posterior fossa group B ependymoma 1.200 1.1e-06
non primary Sjogren syndrome sicca 1.200 2.4e-02
ovarian cancer 1.300 2.4e-04

Gene RIF (5)

25619743 In luciferase assays, TdIF1 can up-regulate transcription activity of the promoters containing the TdIF1-binding sequences, and this effect is mainly through the palindrome 5'-TGCATG-3'.
23874396 TdIF1 associates with the RAB20 promoter, and RAB20 gene transcription is reduced in TdIF1-knocked-down cells, suggesting that TdIF1 stimulates RAB20 gene transcription.
21258344 During cell division, DNTTIP1 is part of the mitotic deacetylase complex MIDAC, which also contains C14ORF43/MIDEAS and HDAC1/HDAC2.
21258344 During cell division, DNTTIP1 forms a complex with C14ORF43/MIDEAS and HDAC1/HDAC2.
17663723 The TdT binding, DNA binding and dimerization regions, and nuclear localization signal (NLS) in TdIF1, were identified.

AA Sequence


Text Mined References (20)

PMID Year Title
25653165 2015 Structural and functional characterization of a cell cycle associated HDAC1/2 complex reveals the structural basis for complex assembly and nucleosome targeting.
25619743 2015 Definition of the transcription factor TdIF1 consensus-binding sequence through genomewide mapping of its binding sites.
25416956 2014 A proteome-scale map of the human interactome network.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23874396 2013 TdIF1 recognizes a specific DNA sequence through its Helix-Turn-Helix and AT-hook motifs to regulate gene transcription.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
21573134 2011 Nuclear cGMP-dependent kinase regulates gene expression via activity-dependent recruitment of a conserved histone deacetylase complex.
21258344 2011 Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes.
19690332 2009 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
18669648 2008 A quantitative atlas of mitotic phosphorylation.
17663723 2007 Identification of functional domains in TdIF1 and its inhibitory mechanism for TdT activity.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
17081983 2006 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
16371131 2006 Direct binding of TReP-132 with TdT results in reduction of TdT activity.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12766061 2003 Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11780052 2001 The DNA sequence and comparative analysis of human chromosome 20.
11473582 2001 Terminal deoxynucleotidyltransferase directly interacts with a novel nuclear protein that is homologous to p65.