Tbio DNER Delta and Notch-like epidermal growth factor-related receptor

Protein Summary

Description

Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity).

Uniprot Accession IDs

• Q8NFT8
• A6NP39
• Q53R88
• Q53TP7
• Q53TQ5
• Q8IYT0
• Q8TB42
• Q9NTF1
• Q9UDM2

Gene Name

• DNER

Ensembl ID

• ENST00000341772
• ENSP00000345229
• ENSG00000187957

Symbol

• BET
• bet
• UNQ26

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
gene perturbation	0.86
PubMedID	0.82
kinase perturbation	0.76
trait	0.75

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.53   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 213   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.53   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0