| Tbio | Homeobox protein DLX-3 |
Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. Trichodentoosseous syndrome (TDO), an autosomal dominant condition, has been correlated with DLX3 gene mutation. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 17. Mutations in this gene have been associated with the autosomal dominant conditions trichodentoosseous syndrome and amelogenesis imperfecta with taurodontism. [provided by RefSeq, Jul 2008]
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. Trichodentoosseous syndrome (TDO), an autosomal dominant condition, has been correlated with DLX3 gene mutation. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 17. Mutations in this gene have been associated with the autosomal dominant conditions trichodentoosseous syndrome and amelogenesis imperfecta with taurodontism. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Amelogenesis Imperfecta, Type IV | 1 | 0.0 | 0.0 |
| TRICHODENTOOSSEOUS SYNDROME | 1 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| medulloblastoma, large-cell | 6086 | 3.0e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Dental Enamel Hypoplasia | 42 | 6.135 | 3.1 |
| Dentinogenesis imperfecta | 21 | 3.774 | 1.9 |
| Dentin dysplasia | 15 | 3.77 | 1.9 |
| Alstrom syndrome | 6 | 3.716 | 1.9 |
| Hypophosphatasia | 10 | 3.497 | 1.7 |
| Melorheostosis | 3 | 3.464 | 1.7 |
| Incontinentia pigmenti achromians | 5 | 3.267 | 1.6 |
| Osteogenesis imperfecta | 31 | 3.226 | 1.6 |
| Placental insufficiency | 17 | 3.187 | 1.6 |
| Tooth agenesis | 42 | 3.132 | 1.6 |
| Disease | Target Count |
|---|---|
| Amelogenesis imperfecta type 4 | 8 |
| Tricho-dento-osseous syndrome | 1 |
MSGSFDRKLSSILTDISSSLSCHAGSKDSPTLPESSVTDLGYYSAPQHDYYSGQPYGQTVNPYTYHHQFN 1 - 70 LNGLAGTGAYSPKSEYTYGASYRQYGAYREQPLPAQDPVSVKEEPEAEVRMVNGKPKKVRKPRTIYSSYQ 71 - 140 LAALQRRFQKAQYLALPERAELAAQLGLTQTQVKIWFQNRRSKFKKLYKNGEVPLEHSPNNSDSMACNSP 141 - 210 PSPALWDTSSHSTPAPARSQLPPPLPYSASPSYLDDPTNSWYHAQNLSGPHLQQQPPQPATLHHASPGPP 211 - 280 PNPGAVY 281 - 287 //
