Tbio DLEC1 Deleted in lung and esophageal cancer protein 1

Protein Summary

Description

May act as a tumor suppressor by inhibiting cell proliferation. The cytogenetic location of this gene is 3p21.3, and it is located in a region that is commonly deleted in a variety of malignancies. Down-regulation of this gene has been observed in several human cancers including lung, esophageal, renal tumors, and head and neck squamous cell carcinoma. In some cases, reduced expression of this gene in tumor cells is a result of aberrant promoter methylation. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins.[provided by RefSeq, Mar 2016]

Uniprot Accession IDs

• Q9Y238
• Q9NSW0
• Q9NTG5

Gene Name

• DLEC1

Ensembl ID

• ENST00000308059
• ENSP00000308597
• ENSG00000008226
• ENST00000346219
• ENSP00000315914

Symbol

• DLC1
• F56
• DLC1
• DLC-1
• CFAP81

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein) perturbation	0.83
cell line	0.58
cell type or tissue	0.56
tissue sample	0.5
histone modification site profile	0.49

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.38   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 167   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.38   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0