You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
DIRAS3
GTP-binding protein Di-Ras3

Protein Summary
Description
This gene encodes a member of the ras superfamily. This gene is imprinted gene with monoallelic expression of the paternal allele which is associated with growth suppression. The encoded protein acts as a tumor suppressor whose function is abrogated in many ovarian and breast cancers. This protein may also play a role autophagy in certain cancer cells by regulating the autophagosome initiation complex. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370981
  • ENSP00000360020
  • ENSG00000162595
  • ENST00000646789
  • ENSP00000495736

Symbol
  • ARHI
  • NOEY2
  • RHOI
  • ARHI
  • NOEY2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
PubMedID
0.7
cell type or tissue
0.64
protein domain
0.58
gene perturbation
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.42   (req: < 5)
Gene RIFs: 60   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.42   (req: >= 5)
Gene RIFs: 60   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0