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Tbio
DIAPH3
Protein diaphanous homolog 3

Protein Summary
Description
Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Required for cytokinesis, stress fiber formation and transcriptional activation of the serum response factor. Binds to GTP-bound form of Rho and to profilin: acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity. This gene encodes a member of the diaphanous subfamily of the formin family. Members of this family are involved in actin remodeling and regulate cell movement and adhesion. Mutations in this gene are associated with autosomal dominant auditory neuropathy 1. Multiple transcript variants encoding different isoforms have been f ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267215
  • ENSP00000267215
  • ENSG00000139734
  • ENST00000377908
  • ENSP00000367141
  • ENST00000400319
  • ENSP00000383173
  • ENST00000400320
  • ENSP00000383174
  • ENST00000400324
  • ENSP00000383178
  • ENST00000465066
  • ENSP00000478137
  • ENST00000498416
  • ENSP00000479091

Symbol
  • DIAP3
  • AN
  • DIA2
  • DRF3
  • AUNA1
  • NSDAN
  • diap3
  • mDia2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
protein domain
0.97
trait
0.93
hub protein
0.92
transcription factor binding site profile
0.86


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.63   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 239   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.63   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 239   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0