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Tbio
DERL3
Derlin-3

Protein Summary
Description
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded glycoproteins (PubMed:16449189, PubMed:22607976). May be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). The protein encoded by this gene belongs to the derlin family, and resides in the endoplasmic reticulum (ER). Proteins that are unfolded or misfolded in the ER must be refolded or degraded to maintain the homeostasis of the ER. This protein appears to be involved in the degradation ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318109
  • ENSP00000315303
  • ENSG00000099958
  • ENST00000406855
  • ENSP00000384744
  • ENST00000476077
  • ENSP00000419399
  • ENST00000620697
  • ENSP00000483693
  • ENSG00000274437
  • ENST00000628868
  • ENSP00000485763
  • ENST00000631305
  • ENSP00000486587

Symbol
  • C22orf14
  • DER3
  • LLN2
  • IZP6
  • LLN2
  • C22orf14
  • derlin-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.67
transcription factor
0.64
gene perturbation
0.59
tissue sample
0.54
PubMedID
0.52


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.46   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.46   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0