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Tchem
DEPTOR
DEP domain-containing mTOR-interacting protein

Protein Summary
Description
Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286234
  • ENSP00000286234
  • ENSG00000155792
  • ENST00000523492
  • ENSP00000430457

Symbol
  • DEPDC6
  • DEP.6
  • DEPDC6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
transcription factor binding site profile
0.86
small molecule perturbation
0.78
virus perturbation
0.68
PubMedID
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.21   (req: < 5)
Gene RIFs: 69   (req: <= 3)
Antibodies: 246   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.21   (req: >= 5)
Gene RIFs: 69   (req: > 3)
Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0