| Tbio | Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 |
Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase.
This gene encodes a bifunctional enzyme that is involved in the biosynthesis of phytosphingolipids in human skin and in other phytosphingolipid-containing tissues. This enzyme can act as a sphingolipid delta(4)-desaturase, and also as a sphingolipid C4-hydroxylase. [provided by RefSeq, Oct 2008]
This gene encodes a bifunctional enzyme that is involved in the biosynthesis of phytosphingolipids in human skin and in other phytosphingolipid-containing tissues. This enzyme can act as a sphingolipid delta(4)-desaturase, and also as a sphingolipid C4-hydroxylase. [provided by RefSeq, Oct 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| posterior fossa group A ependymoma | 468 | 1.3e-06 |
| glioblastoma | 5792 | 6.0e-06 |
| atypical teratoid / rhabdoid tumor | 5112 | 2.8e-05 |
| Astrocytoma, Pilocytic | 3081 | 7.6e-05 |
| adult high grade glioma | 3801 | 1.7e-04 |
| breast carcinoma | 1638 | 3.3e-04 |
| medulloblastoma, large-cell | 6241 | 1.1e-03 |
| interstitial cystitis | 2312 | 1.1e-03 |
| ductal carcinoma in situ | 1745 | 2.9e-03 |
| group 4 medulloblastoma | 1855 | 3.6e-03 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 1.0e-02 |
| invasive ductal carcinoma | 2951 | 1.1e-02 |
| facioscapulohumeral dystrophy | 288 | 5.0e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Heart disease | 306 | 0.0 | 2.7 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.600 | 1.7e-04 |
| Astrocytoma, Pilocytic | -1.200 | 7.6e-05 |
| atypical teratoid / rhabdoid tumor | -1.300 | 2.8e-05 |
| breast carcinoma | 1.100 | 3.3e-04 |
| ductal carcinoma in situ | 1.400 | 2.9e-03 |
| facioscapulohumeral dystrophy | 1.600 | 5.0e-02 |
| glioblastoma | -1.200 | 6.0e-06 |
| group 4 medulloblastoma | -1.100 | 3.6e-03 |
| interstitial cystitis | -1.700 | 1.1e-03 |
| intraductal papillary-mucinous adenoma (... | 1.600 | 1.0e-02 |
| invasive ductal carcinoma | 1.100 | 1.1e-02 |
| medulloblastoma, large-cell | -1.300 | 1.1e-03 |
| posterior fossa group A ependymoma | -1.100 | 1.3e-06 |
MGNSASRSDFEWVYTDQPHTQRRKEILAKYPAIKALMRPDPRLKWAVLVLVLVQMLACWLVRGLAWRWLL 1 - 70 FWAYAFGGCVNHSLTLAIHDISHNAAFGTGRAARNRWLAVFANLPVGVPYAASFKKYHVDHHRYLGGDGL 71 - 140 DVDVPTRLEGWFFCTPARKLLWLVLQPFFYSLRPLCVHPKAVTRMEVLNTLVQLAADLAIFALWGLKPVV 141 - 210 YLLASSFLGLGLHPISGHFVAEHYMFLKGHETYSYYGPLNWITFNVGYHVEHHDFPSIPGYNLPLVRKIA 211 - 280 PEYYDHLPQHHSWVKVLWDFVFEDSLGPYARVKRVYRLAKDGL 281 - 323 //
