Protein Summary
Has antibacterial activity. Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The protein encoded by this gene is secreted and is a member of the beta defensin protein family. This protein binds spermatozoa and has antimicrobial activity against E. coli. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13. [provided by RefSeq, Nov 2014]
- ENST00000382376
- ENSP00000371813
- ENSG00000186458
- DEFB32
- BD-32
- DEFB32
- HEL-75
- UNQ827
- DEFB-32
- KFLL827
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cell line | 0.49 | ||
microRNA | 0.47 | ||
tissue | 0.39 | ||
tissue sample | 0.35 | ||
biological term | 0.33 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.55 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 80 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.55 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 80 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0