Property Summary

NCBI Gene PubMed Count 113
PubMed Score 172.55
PubTator Score 259.69

Knowledge Summary


No data available


Accession P81534 Q8NFG6 Q9NPF6
Symbols BD-3




  Ortholog (1)

Species Source Disease
Chimp OMA Inparanoid

Gene RIF (105)

26733497 epidermal growth factor receptor (EGFR)activation via phosphorylation of EGFR via TAK1-p38alpha pathway, and subsequent internalization of EGFR are functionally linked to the induction of hBD3 in gastric epithelial cells infected with H. pylori.
26688341 These results demonstrate that the gamma-core within HBD3 is the ancestral core of the full-length molecule and is a viable HDP per se, since it is endowed with the most important biological features of HBD3
26646717 Using bone marrow derived macrophages from knockout mice we demonstrate that hBD3 suppresses the polyI:C-induced TLR3 response mediated by TICAM1 (TRIF), while exacerbating the cytoplasmic response through MDA5 (IFIH1) and MAVS (IPS1/CARDIF).
26539799 HBD2 or HBD3 cointernalized with virions in endosomes, formed oligomers, and reduced infectivity of human immunodeficiency virus.
26536271 Study found that HBD2 bound tightly to Mc1r with an affinity similar to that of HBD3
26417692 M. catarrhalis induced hBD-3 expression in pulmonary epithelial cells, which was dependent on M. catarrhalis membranous lipoolygosaccharide.
26347021 C-terminal 15-mer peptide within hBD3, designated as hBD3-3, has cell- and skin-penetrating activity, which can induce anti-inflammatory activity
26302933 TLR1, TLR2 and CCR2 were expressed on NK cells, and in NK culture experiments we observed hBD-3 to directly act on NK cells, resulting in CD69 upregulation and IFNgamma secretion. We also observed mDC-hBD-3 enhanced NK cytolytic activity and IFNgamma production.
26224324 the role of DEFB103 gene copy number variation (CNV) in ankylosing spondylitis (AS) susceptibility, was investigated.
26038828 there is a significant link between innate immunity deregulation through disruption of cationic peptides (hBDs) and the potential development of colon cancer.
25541254 hBD-3 stimulates IL-37 expression through CCR6 in keratinocytes
25512526 the effect of pH on the activity of an ASL defensin, human beta-defensin-3 (hBD-3), and the cathelicidin-related peptide, LL-37. We found that reducing pH from 8.0 to 6.8 reduced the ability of both peptides to kill Staphylococcus aureus.
25381795 our simulation shows that C3 peptides(C3 is a chimera from human b-defensins 2 and 3) can make anionic lipids clustered in the bacterial membrane.
24969834 Study demonstrates that hBD-3 inhibits the progression of colon cancer in a paracrine fashion through downregulation of MTA2 expression.
24956228 hBD3 might participate in intestinal wound healing by promoting enterocyte migration and show beneficial effects on newborn rats with necrotizing enterocolitis.
24831548 EGFR inhibitors suppressed keratinocyte expression of hBD2 and 3 induced by S. epidermidis.
24747887 epidermal growth factor-dependent RNase 7 and human beta-defensin-3 expression upon infection with Trichophytum rubrum
24633129 human beta-defensin-3, improves the function of the epithelial tight-junction barrier in human keratinocytes.
24579469 Recombinant hBD-3 can up-regulated the expression of TLR2, IL-17A and IL-22.
24120511 Data show that Lactobacillus crispatus promotes epithelial cell defense against Candida albicans infection through the involvement of TLR2/4, IL-8 and human beta-defensin 2 and 3, suggesting this Lactobacillus as an anti-infective agent against C. albicans.
23829433 Alterations in chemokine production or their receptors in monocytes of HIV-infected persons could influence cell migration and modify the effects of hBD-3 at sites of inflammation.
23790489 Human beta-defensin 3 behaves as a neutral antagonist at both the MC1R and the MC4R, blocking the effects of the inverse agonists ASIP and AGRP.
23774076 Expressions of hBD-2 and hBD-3 mRNA are up-regulated in nongonococcal cervicitis, suggesting the role of mucosal immunity in nongonococcal cervicitis.
23698749 hBD2 and hBD3 induce sustained divalent calcium (Ca2+) mobilization and substantial degranulation in human mast cells, with hBD3 being more potent.
23659571 Mapping of key residues in the interaction between human Beta-defensin 3 and CXCR4 reveals key defensin motifs involved in protein binding.
23614747 Levels of psoriasin, RNase 7 and hBD-3 expression - assessed by immunohistochemistry - varied between different body localisations.
23608825 overexpressed in both sporadic inclusion body myositis and polymyositis
23499548 visfatin enhances CAMP, hBD-2, hBD-3, and S100A7 production in human keratinocytes and their orthologs in murine imiquimod-treated psoriatic skin.
23204181 DEFB1 promoter polymorphisms may promote persistent S. aureus colonization by reducing hbd-1 and hbd-3 expression in keratinocytes of human skin.
23204181 DEFB1 polymorphisms promote persistent S. aureus colonization by lowering beta-defensin-3 expression in keratinocytes of human skin.
23133681 This study demonstrates that hBD3 is induced in leprosy Type 1 Reactions and suppressed by corticosteroids.
22951718 These results suggest an important role for hBD3 in inducing dendritic cell activation, migration, and polarization.
22860513 Both Streptococcus gordonii and Porphyromonas gingivalis induced the mRNA-expression of hBD-2 and hBD-3 in gingival epithelial cells as well as fibroblasts after 24 hrs.
22837529 Preincubation of monocytes with molecules that bind PS protected these cells from hBD-3-induced membrane damage, suggesting that outer-membrane PS expression can at least partially explain monocyte susceptibility to hBD-3
22704618 During prolonged infection, hBD3 was subsequently downregulated by the Helicobacter pylori virulence determinant CagA.
22572817 results identify HBD3 as an antagonist of the MC1R that is expressed in human melanocytes and shed new light on the regulation of MC1R expression and activity by its agonist and antagonists.
22444247 HBD3 is expressed in tonsils and its levels are reduced in patients with allergic rhinitis.
22418431 SP-A protects lung epithelium from tissue injury caused by BD3
22391815 The role of Immunosuppressive neutrophils on the production of human beta-defensins (HBDs), important molecules on host antimicrobial innate immunities, by human keratinocytes was studied.
22386945 Binding of peptides corresponding to the carboxy-terminal region of human-beta-defensins-1-3 with model membranes investigated by isothermal titration calorimetry.
22364200 Beta-defensin 3 may be a novel melanocortin-1 receptor agonist involved in regulating melanocyte responses in humans.
22296408 Differential regulation of the expression of hBD-2 and hBD-3 might play an important role in pneumococci pneumonia.
22232436 In BK, hBD3 gene expression was moderately increased and then decreased after healing.
22035653 Overexpression of hBD-3 was associated with lymphatic invasion of oral squamous cell carcinoma tissue (OSCC); hBD-3 expression upregulated by LPS via EGFR signaling pathways can enhance metastasis of OSCC cells.
22023339 Xog1p is one of the LL37/hBD-3 targets, and elevated beta-1,3-exoglucanase activity reduces C. albicans adhesion to plastic.
21843332 Under the condition of bisphosphonate-associated osteonecrosis of the jaws an increased expression of hBD-1,-2,-3 is detectable.
21809339 these findings suggest that the mechanism of hBD3 anti-inflammatory activity involves specific targeting of toll-like receptor signaling pathways
21631237 The stimulation of human fetal membranes with S. agalactiae induced a differential and tissue-specific profile of HBD-1, HBD-2, and HBD-3 secretion.
21470491 hBD-3 secretion in response to Staphylococcus aureus challenge is dysregulated in Wegener's granulomatasis, and this might be one reason for higher S. aureus colonisation rates in WG.
21464083 Persistent nasal carriers of Staphylococcus aureus show deficient upregulation of hBD3 in skin after experimental wounding in vivo.
21442129 Data show that high-glucose conditions inhibited the BD3 expression of epidermal keratinocytes.
21393042 DEFB103 copy number does not influence Staphylococcus aureus nasal carrier status.
21387465 A worldwide analysis of beta-defensin copy-number variable in 67 populations shows an unusually high frequency of high-DEFB103-expressing copies in East Asia the geographical origin of historical and modern influenza epidemics
21071608 Human beta-defensin 3 represents a novel NF-kappaB-regulated mediator of CCR7 expression and anti-apoptotic pathways.
20819126 In periodontally healthy subjects, HBD-2 and HBD-3 levels are not influenced by stress.
20483750 human beta-defensin (hBD)2 and 3 and their mouse orthologs, beta-defensin 4 and 14 contribute to the innate and adaptive immune response in their role as chemoattractants
20483368 Observational study of gene-disease association. (HuGE Navigator)
20385753 The authors report that binding of hBD3 to defined, lipid II-rich sites of cell wall biosynthesis may lead to perturbation of the biosynthesis machinery, resulting in localized lesions in the cell wall as demonstrated by electron microscopy.
20128731 The mRNA level of the beta defensin 3 did not differ significantly between the two subgroups.
20104491 Human BD3 lacks pro-inflammatory activity in human & mouse primary macrophages. It plays a dual role in antimicrobial activity and resolution of inflammation.
19995893 T. denticola suppressed the expression of HBD-3 by inhibiting the TLR2 axis in gingival epithelial cells.
19741426 Authors detected three rare variants in HBD3 in melanoma: two in intron 1 (53IN1 A/G and 56IN1 G/A) and a coding variant (Arg34Lys G/A in exon 1).
19734018 Histamine induces human beta-defensin-3 production in human keratinocytes.
19702947 The ability to be induced was significantly reduced in OSCC.
19675119 differential modulation of expression in gingival epithelia by Porphyromonas gingivalis lipopolysaccharide isoforms
19580334 Results describe the structures of three C-terminal (R36-K45) analogues of human beta-defensin-3 as studied by 1H NMR spectroscopy and extensive molecular dynamics simulations.
19554343 no association of amniotic fluid HBD3 with preterm birth
19480463 Results indicate that in addition to the number of positively charged residues and hydrophobic residues, the arrangement of these residues in the 3-D space is important to the antimicrobial selectivity and salt-dependent activity beta defensins.
19219676 Increased expression of beta-defensin 3 is associated with oral squamous cell carcinomas.
19194307 Observational study of gene-disease association. (HuGE Navigator)
19108000 Results describe a reaction mechanism to elucidate the oxidation results of two linear cysteine-containing peptide analogues of human beta-defensin 3.
18925411 bacterial induction of HBD-3 via TLR-2 and -4 in bone
18711400 HBD3 binds recombinant hemagglutinin B (rHagB), a non-fimbrial adhesin from Porphyromonas gingivalis and this interaction may be an important initial step to attenuate a pro-inflammatory cytokine response and an ERK 1/2 response.
18627502 expression was found even in non-inflamed pseudocysts such as mucoceles
18538383 Patients with atopic dermatitis have problems with S. aureus skin infection. This is a result of increased levels of T(H)2 cytokines, which inhibit keratinocyte mobilization of HBD-3.
18452706 Francisella tularensis LVS infection has no effect on the level of hBD-3 in airway epithelial cells.
18385759 p21, a cyclin-dependent kinase inhibitor downstream of S100/A11, is required for calcium-mediated induction of HBD-3 and filaggrin.
18345485 Results indicate that lipopolysaccharide-induced activation of Toll-like receptor 4 in chorioamnionitis triggers increased production of beta-defensin 3.
18345484 Results describe the relationship between human beta-defensin 3 (hBD3) expression and mean histamine concentration in human placental tissue.
18180295 chemoattractant and antimicrobial activities of beta-defensins can be separated, and both of these functions are independent of intramolecular disulfide bonds
18167348 both hBD3 and mBD14 were chemotactic for freshly isolated mouse resident peritoneal cells. Thus, mBD14, based on structural and functional similarities, appears to be an orthologue of hBD3.
18006661 activation of NF-kappaB by hBD-3 depends on the expression of both TLR1 and TLR2
17460726 Blocking peptide binding of HBD3 inhibited killing of the bacteria, indicating an essential role for beta-defensin 3 in the constitutive killing of bacteria by normal keratinocytes.
17415576 As compared to healthy controls, skin of patients with mycosis fungoides (non-lesional and lesional) and atopic dermatitis patients showed significantly lower hBD-1 mRNA expression and significantly higher hBD-2 and hBD-3 mRNA expression.
17015038 deficiency in human beta defensin-3 expression is an acquired rather than a constitutive defect
17007044 Our results suggest that like hBD-2, hBD-3 may be involved in the pathophysiology of H. pylori-induced gastritis.
16954397 The gene expression of hBD-3 in primary human keratinocytes upon contact with S. aureus was studied.
16818731 Recombinant human beta-defensin 3 induces internalization of HIV-1 coreceptor CXCR4 without promoting calcium flux, ERK-1/2 phosphorylation, or chemotaxis.
16778986 hBD-3 is strongly induced in human skin wounds
16741514 hyphal-invasion-dependent inhibition of defensin expression in oral epithelium that undermines the host surveillance system represents a hitherto undescribed novel pathogenic mechanism of C. albicans
16634647 results demonstrate that antimicrobial activity & absence of cytotoxicity can be explained by lipid-specificity of hBD3; clear correlation between these aspects of biological activity of hBD3 & its interaction with lipid matrices could be found.
16034119 Human beta defensin-3 activates normal human keratinocytes to secrete IL-18
15934078 beta-defensin 3 (HBD-3) is a multifunctional antimicrobial peptide with the ability to link host defense mechanisms and inflammation with tissue-remodeling processes in articular cartilage.
15829297 The expression of HBD3 and two other beta defensins was correlated with induction profiles in gingival keratinocytes.
15820309 Observational study of gene-disease association. (HuGE Navigator)
14981906 Expression of HBD-3 was detected only in areas adjacent to squamous cell carcinomas
14714554 Calcium triggers beta-defensin (hBD-2 and hBD-3) and chemokine macrophage inflammatory protein-3 alpha (MIP-3alpha/CCL20) expression in monolayers of activated human keratinocytes
14703118 the level of expression of hBD-1 mRNA is lower and that of hBD-3 was higher than that of hBD-2 in reconstructed epidermis
12892899 human endometrium expresses both HBD3 and HBD4 in a cycle-dependent manner; these natural antimicrobials will contribute to innate defences present in human endometrium protecting against uterine infection
12840147 disulfide bonding in hBD3, although required for binding and activation of receptors for chemotaxis, is fully dispensable for its antimicrobial function
12825122 expression pattern of hBD-3 mRNA by in situ hybridization in normal oral epithelium, leukoplakia, and lichen planus
12727027 Expression of mRNA is upregulated during differentation of keratinocyte immortalized cell lines.
12013554 important role in the innate oral epithelial host defense
11741980 HBD-3 is a dimer, while HBD-1 and HBD-2 are monomeric. Subsequently, the NMR solution structures of HBD1 and HBD3 were determined using standard homonuclear techniques and compared with the previously determined solution structure of HBD2
11223260 HBD-3 is a broad-spectrum, inducible cationic antimicrobial peptide expressed at mucosal surfaces including pulmonary epithelia, esophagus, skin, placenta and gingiva. May also act as a chemokine for adaptive immune cells.

AA Sequence


Text Mined References (113)

PMID Year Title
26733497 2016 Novel epidermal growth factor receptor pathway mediates release of human ?-defensin 3 from Helicobacter pylori-infected gastric epithelial cells.
26688341 2015 An ancestral host defence peptide within human ?-defensin 3 recapitulates the antibacterial and antiviral activity of the full-length molecule.
26646717 2015 Human ?-Defensin 3 [corrected] Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic:Polycytidylic Acid.
26539799 2016 Human beta-defensins 2 and -3 cointernalize with human immunodeficiency virus via heparan sulfate proteoglycans and reduce infectivity of intracellular virions in tonsil epithelial cells.
26536271 2015 Electrostatic Similarity Analysis of Human ?-Defensin Binding in the Melanocortin System.
26417692 2015 The role and regulation of Moraxella catarrhalis-induced human beta-defensin 3 expression in human pulmonary epithelial cells.
26367466 2015 Cytotoxicity of HBD3 for dendritic cells, normal human epidermal keratinocytes, hTERT keratinocytes, and primary oral gingival epithelial keratinocytes in cell culture conditions.
26347021 2015 Identification of a cell-penetrating peptide domain from human beta-defensin 3 and characterization of its anti-inflammatory activity.
26302933 2015 HBD-3 induces NK cell activation, IFN-? secretion and mDC dependent cytolytic function.
26224324 2015 Association between DEFB103 gene copy number variation and ankylosing spondylitis: a case-control study.
26038828 2015 Expression and new exon mutations of the human Beta defensins and their association on colon cancer development.
25541254 2015 Human ?-defensin-3 increases the expression of interleukin-37 through CCR6 in human keratinocytes.
25512526 2014 pH modulates the activity and synergism of the airway surface liquid antimicrobials ?-defensin-3 and LL-37.
25381795 2015 Insight into the impact of environments on structure of chimera C3 of human ?-defensins 2 and 3 from molecular dynamics simulations.
24969834 2014 Human ?-defensin-3 inhibits migration of colon cancer cells via downregulation of metastasis-associated 1 family, member 2 expression.
24956228 2014 Human ?-defensin-3 promotes intestinal epithelial cell migration and reduces the development of necrotizing enterocolitis in a neonatal rat model.
24831548 2014 Epidermal growth factor receptor inhibitors selectively inhibit the expressions of human ?-defensins induced by Staphylococcus epidermidis.
24747887 2014 Infection of keratinocytes with Trichophytum rubrum induces epidermal growth factor-dependent RNase 7 and human beta-defensin-3 expression.
24633129 2014 Host defense (Antimicrobial) peptide, human ?-defensin-3, improves the function of the epithelial tight-junction barrier in human keratinocytes.
24579469 2013 [The effects of recombinant human beta-defensin-3 on expression of interleukin-17A and interleukin-22 in BEAS-2B cell].
24120511 Lactobacillus crispatus modulates epithelial cell defense against Candida albicans through Toll-like receptors 2 and 4, interleukin 8 and human ?-defensins 2 and 3.
23829433 2013 Human ? defensin-3 induces chemokines from monocytes and macrophages: diminished activity in cells from HIV-infected persons.
23790489 2013 Molecular and functional analysis of human ?-defensin 3 action at melanocortin receptors.
23774076 2013 Human ?-defensin messenger RNA is overexpressed in the cervical epithelia of patients with nongonococcal cervicitis.
23698749 2013 ?-Defensins activate human mast cells via Mas-related gene X2.
23659571 2013 Human ?-defensin-3 structure motifs that are important in CXCR4 antagonism.
23614747 2013 Differential expression and in vivo secretion of the antimicrobial peptides psoriasin (S100A7), RNase 7, human beta-defensin-2 and -3 in healthy human skin.
23608825 2014 Human ?-defensin-3 correlates with muscle fibre degeneration in idiopathic inflammatory myopathies.
23499548 2013 Visfatin enhances the production of cathelicidin antimicrobial peptide, human ?-defensin-2, human ?-defensin-3, and S100A7 in human keratinocytes and their orthologs in murine imiquimod-induced psoriatic skin.
23204181 2013 Impaired ?-defensin expression in human skin links DEFB1 promoter polymorphisms with persistent Staphylococcus aureus nasal carriage.
23133681 2012 Human beta-defensin 3 is up-regulated in cutaneous leprosy type 1 reactions.
22951718 2013 Human beta-defensin 3 induces maturation of human langerhans cell-like dendritic cells: an antimicrobial peptide that functions as an endogenous adjuvant.
22860513 2012 Antimicrobial responses of primary gingival cells to Porphyromonas gingivalis.
22837529 2012 Membrane damage and repair in primary monocytes exposed to human ?-defensin-3.
22704618 2012 The Helicobacter pylori virulence effector CagA abrogates human ?-defensin 3 expression via inactivation of EGFR signaling.
22572817 2012 Defining MC1R regulation in human melanocytes by its agonist ?-melanocortin and antagonists agouti signaling protein and ?-defensin 3.
22444247 2012 Reduced tonsillar expression of human ?-defensin 1, 2 and 3 in allergic rhinitis.
22418431 2012 Pulmonary surfactant protein A protects lung epithelium from cytotoxicity of human ?-defensin 3.
22391815 2012 Impaired ability of burn patient neutrophils to stimulate ?-defensin production by keratinocytes.
22386945 2012 Binding of peptides corresponding to the carboxy-terminal region of human-?-defensins-1-3 with model membranes investigated by isothermal titration calorimetry.
22364200 2012 Melanocortin-1 receptor-mediated signalling pathways activated by NDP-MSH and HBD3 ligands.
22296408 2012 Streptococcus pneumoniae induces human ?-defensin-2 and -3 in human lung epithelium.
22232436 2012 Variable expression of human Beta defensins 3 and 9 at the human ocular surface in infectious keratitis.
22035653 2011 Human beta-defensin-3 (hBD-3) upregulated by LPS via epidermal growth factor receptor (EGFR) signaling pathways to enhance lymphatic invasion of oral squamous cell carcinoma.
22023339 2012 LL37 and hBD-3 elevate the ?-1,3-exoglucanase activity of Candida albicans Xog1p, resulting in reduced fungal adhesion to plastic.
21843332 2011 Increased human defensine levels hint at an inflammatory etiology of bisphosphonate-associated osteonecrosis of the jaw: an immunohistological study.
21809339 2011 Human ?-defensin 3 affects the activity of pro-inflammatory pathways associated with MyD88 and TRIF.
21631237 2012 Evidence of in vitro differential secretion of human beta-defensins-1, -2, and -3 after selective exposure to Streptococcus agalactiae in human fetal membranes.
21470491 Antimicrobial peptides in nasal secretion and mucosa with respect to S. aureus colonisation in Wegener´s granulomatosis.
21464083 2011 Persistent nasal carriage of Staphylococcus aureus is associated with deficient induction of human beta-defensin 3 after sterile wounding of healthy skin in vivo.
21442129 2011 High-Glucose Environment Inhibits p38MAPK Signaling and Reduces Human ?-Defensin-3 Expression [corrected] in Keratinocytes.
21393042 2011 Human ?-defensin 3 (DEFB103) and its influence on Staphylococcus aureus nasal carriage.
21387465 2011 A worldwide analysis of beta-defensin copy number variation suggests recent selection of a high-expressing DEFB103 gene copy in East Asia.
21115716 2011 Role of defensins in corneal epithelial barrier function against Pseudomonas aeruginosa traversal.
21071608 2011 Human ?-defensin 3 promotes NF-?B-mediated CCR7 expression and anti-apoptotic signals in squamous cell carcinoma of the head and neck.
20819126 2010 Psychological stress has no association with salivary levels of ?-defensin 2 and ?-defensin 3.
20483750 2010 Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2.
20483368 2010 Analysis of beta-defensin and Toll-like receptor gene copy number variation in celiac disease.
20404083 2010 Severity of Staphylococcus aureus infection of the skin is associated with inducibility of human beta-defensin 3 but not human beta-defensin 2.
20385753 2010 Human beta-defensin 3 inhibits cell wall biosynthesis in Staphylococci.
20128731 2010 Low expression of human beta-defensin 1 in duodenum of celiac patients is partially restored by a gluten-free diet.
20104491 2010 Human beta-defensin 3 has immunosuppressive activity in vitro and in vivo.
19995893 2010 Treponema denticola suppresses expression of human {beta}-defensin-3 in gingival epithelial cells through inhibition of the toll-like receptor 2 axis.
19741426 2009 Human beta-defensins (HBD1 and HBD3) and malignant melanoma susceptibility.
19734018 2009 Histamine induces human beta-defensin-3 production in human keratinocytes.
19702947 2009 Loss of human beta-defensin 1, 2, and 3 expression in oral squamous cell carcinoma.
19675119 2009 Differential modulation of human {beta}-defensins expression in human gingival epithelia by Porphyromonas gingivalis lipopolysaccharide with tetra- and penta-acylated lipid A structures.
19580334 2009 Structure-dependent charge density as a determinant of antimicrobial activity of peptide analogues of defensin.
19554343 2010 The role of human beta defensins 2 and 3 in the second trimester amniotic fluid in predicting preterm labor and premature rupture of membranes.
19480463 2009 Structure, dynamics, and activity of an all-cysteine mutated human beta defensin-3 peptide analogue.
19219676 2009 Expression profile of human beta-defensin 3 in oral squamous cell carcinoma.
19194307 2009 Copy number variation of defensin genes and HIV infection in Brazilian children.
19108000 2009 Effect of structural parameters of peptides on dimer formation and highly oxidized side products in the oxidation of thiols of linear analogues of human beta-defensin 3 by DMSO.
18925411 2009 Osteoblasts participate in the innate immunity of the bone by producing human beta defensin-3.
18711400 Human beta-defensin 3 binds to hemagglutinin B (rHagB), a non-fimbrial adhesin from Porphyromonas gingivalis, and attenuates a pro-inflammatory cytokine response.
18627502 2008 Expression of human beta-defensin -1, -2, and -3 in non-inflamed pseudocyst, mucoceles.
18538383 2008 Defective killing of Staphylococcus aureus in atopic dermatitis is associated with reduced mobilization of human beta-defensin-3.
18452706 2008 Antimicrobial activity of human beta-defensins and induction by Francisella.
18385759 2008 Th2 cytokines act on S100/A11 to downregulate keratinocyte differentiation.
18345485 2008 Increased production of beta-defensin 3 (hBD-3) by human amniotic epithelial cells (HAEC) after activation of toll-like receptor 4 in chorioamnionitis.
18345484 2008 The relationship between human beta-defensin 3 (hBD3) expression and mean histamine concentration in human placental tissue.
18180295 2008 Analysis and separation of residues important for the chemoattractant and antimicrobial activities of beta-defensin 3.
18167348 2008 Identification and Biological Characterization of Mouse beta-defensin 14, the orthologue of human beta-defensin 3.
18006661 2007 Human -defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2.
17460726 2007 The constitutive capacity of human keratinocytes to kill Staphylococcus aureus is dependent on beta-defensin 3.
17415576 2007 Expression of human beta-defensins in patients with mycosis fungoides.
17015038 2006 Mechanism of HBD-3 deficiency in atopic dermatitis.
17007044 2006 Human beta-defensin-3 induction in H. pylori-infected gastric mucosal tissues.
16954397 2006 Signal transduction and nuclear responses in Staphylococcus aureus-induced expression of human beta-defensin 3 in skin keratinocytes.
16818731 2006 Cutting edge: human beta defensin 3--a novel antagonist of the HIV-1 coreceptor CXCR4.
16778986 2006 Injury-induced innate immune response in human skin mediated by transactivation of the epidermal growth factor receptor.
16741514 2006 Hyphal invasion of Candida albicans inhibits the expression of human beta-defensins in experimental oral candidiasis.
16634647 2006 Lipid-specific membrane activity of human beta-defensin-3.
16034119 2005 The human beta-defensins (-1, -2, -3, -4) and cathelicidin LL-37 induce IL-18 secretion through p38 and ERK MAPK activation in primary human keratinocytes.
15934078 2005 Human beta-defensin 3 mediates tissue remodeling processes in articular cartilage by increasing levels of metalloproteinases and reducing levels of their endogenous inhibitors.
15829297 2005 Correlation between beta-defensin expression and induction profiles in gingival keratinocytes.
15820309 2005 Distribution of human beta-defensin polymorphisms in various control and cystic fibrosis populations.
14981906 Different expression patterns of beta-defensins in human squamous cell carcinomas.
14714554 2003 Calcium triggers beta-defensin (hBD-2 and hBD-3) and chemokine macrophage inflammatory protein-3 alpha (MIP-3alpha/CCL20) expression in monolayers of activated human keratinocytes.
14703118 2003 Use of human reconstructed epidermis to analyze the regulation of beta-defensin hBD-1, hBD-2, and hBD-3 expression in response to LPS.
12892899 2003 Differential expression of the natural antimicrobials, beta-defensins 3 and 4, in human endometrium.
12840147 2003 Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human beta-defensin 3.
12825122 2003 Localization of human beta-defensin 3 mRNA in normal oral epithelium, leukoplakia, and lichen planus: an in situ hybridization study.
12727027 2003 Upregulated expression of human beta defensin-1 and -3 mRNA during differentiation of keratinocyte immortalized cell lines, HaCaT and PHK16-0b.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12375270 2002 Antimicrobial peptides are expressed and produced in healthy and inflamed human synovial membranes.
11741980 2002 The solution structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus.
11714836 2001 Mediators of innate immunity that target immature, but not mature, dendritic cells induce antitumor immunity when genetically fused with nonimmunogenic tumor antigens.
11702237 2001 Identification of a novel, multifunctional beta-defensin (human beta-defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction.
11523142 2001 [Defensins as a mechanism of host defense and innate immunity].
11223260 2001 Discovery of new human beta-defensins using a genomics-based approach.
11085990 2001 Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic.
11076863 2000 DNA cloning using in vitro site-specific recombination.