| Tbio | DNA-binding death effector domain-containing protein 2 |
May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.
This gene encodes a nuclear-localized protein containing a death effector domain (DED). The encoded protein may regulate the trafficking of caspases and other proteins into the nucleus during death receptor-induced apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
This gene encodes a nuclear-localized protein containing a death effector domain (DED). The encoded protein may regulate the trafficking of caspases and other proteins into the nucleus during death receptor-induced apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| osteosarcoma | 7950 | 3.7e-06 |
| pediatric high grade glioma | 1064 | 4.1e-05 |
| glioblastoma | 5792 | 4.9e-05 |
| medulloblastoma, large-cell | 6241 | 6.2e-04 |
| astrocytic glioma | 2597 | 8.0e-03 |
| oligodendroglioma | 2850 | 1.6e-02 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | -1.300 | 8.0e-03 |
| glioblastoma | -1.400 | 4.9e-05 |
| medulloblastoma, large-cell | -1.300 | 6.2e-04 |
| oligodendroglioma | -1.300 | 1.6e-02 |
| osteosarcoma | -2.326 | 3.7e-06 |
| pediatric high grade glioma | -1.200 | 4.1e-05 |
MALSGSTPAPCWEEDECLDYYGMLSLHRMFEVVGGQLTECELELLAFLLDEAPGAAGGLARARSGLELLL 1 - 70 ELERRGQCDESNLRLLGQLLRVLARHDLLPHLARKRRRPVSPERYSYGTSSSSKRTEGSCRRRRQSSSSA 71 - 140 NSQQGQWETGSPPTKRQRRSRGRPSGGARRRRRGAPAAPQQQSEPARPSSEGKVTCDIRLRVRAEYCEHG 141 - 210 PALEQGVASRRPQALARQLDVFGQATAVLRSRDLGSVVCDIKFSELSYLDAFWGDYLSGALLQALRGVFL 211 - 280 TEALREAVGREAVRLLVSVDEADYEAGRRRLLLMEEEGGRRPTEAS 281 - 326 //
