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Tbio
DECR2
Peroxisomal 2,4-dienoyl-CoA reductase

Protein Summary
Description
Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219481
  • ENSP00000219481
  • ENSG00000242612
  • ENST00000439661
  • ENSP00000399697
  • ENST00000613476
  • ENSP00000481547
  • ENSG00000274296
  • ENST00000631856
  • ENSP00000488824

Symbol
  • PDCR
  • SDR17C1
  • PDCR
  • SDR17C1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
cell type or tissue
0.69
gene perturbation
0.63
histone modification site profile
0.63
cell line
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.31   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.31   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0