| Tdark | Probable ATP-dependent RNA helicase DDX60-like |
This gene encodes a member of the DExD/H-box helicase family of proteins, a subset of the super family 2 helicases. Members of the DExD/H-box helicase family share a conserved functional core comprised of two RecA-like globular domains. These domains contain conserved motifs that mediate ATP binding, ATP hydrolysis, nucleic acid binding, and RNA unwinding. In addition to functions in RNA metabolism, members of this family are involved in anti-viral immunity and act as cytosolic sensors of viral nucleic acids. The protein encoded by this gene has been shown to inhibit hepatitis C virus replication in response to interferon stimulation in cell culture. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 3.2e-21 |
| juvenile dermatomyositis | 1187 | 2.0e-15 |
| psoriasis | 6694 | 1.6e-10 |
| glioblastoma | 5792 | 2.3e-08 |
| Astrocytoma, Pilocytic | 3081 | 9.2e-06 |
| ependymoma | 4679 | 1.6e-05 |
| primary Sjogren syndrome | 735 | 2.7e-05 |
| adult high grade glioma | 3801 | 5.3e-05 |
| pancreatic cancer | 2398 | 8.8e-05 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.0e-04 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 2.0e-04 |
| tuberculosis and treatment for 3 months | 179 | 9.6e-04 |
| nasopharyngeal carcinoma | 1058 | 1.6e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 4.6e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 5.4e-03 |
| osteosarcoma | 7950 | 7.8e-03 |
| diabetes mellitus | 1728 | 8.0e-03 |
| Rheumatoid arthritis | 1191 | 8.4e-03 |
| subependymal giant cell astrocytoma | 2287 | 1.2e-02 |
| ovarian cancer | 8520 | 1.3e-02 |
| cystic fibrosis | 1696 | 2.1e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Liver disease | 237 | 0.0 | 1.9 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | 1.700 | 5.3e-05 |
| Astrocytoma, Pilocytic | 1.200 | 9.2e-06 |
| atypical teratoid / rhabdoid tumor | 1.100 | 1.0e-04 |
| cystic fibrosis | 1.300 | 2.1e-02 |
| diabetes mellitus | -1.100 | 8.0e-03 |
| ependymoma | 1.300 | 1.6e-05 |
| glioblastoma | 1.300 | 2.3e-08 |
| intraductal papillary-mucinous adenoma (... | 2.200 | 2.0e-04 |
| intraductal papillary-mucinous carcinoma... | 1.500 | 5.4e-03 |
| intraductal papillary-mucinous neoplasm ... | 2.000 | 4.6e-03 |
| juvenile dermatomyositis | 2.083 | 2.0e-15 |
| lung carcinoma | -2.000 | 3.2e-21 |
| nasopharyngeal carcinoma | 1.200 | 1.6e-03 |
| osteosarcoma | -1.440 | 7.8e-03 |
| ovarian cancer | -1.200 | 1.3e-02 |
| pancreatic cancer | 1.100 | 8.8e-05 |
| primary Sjogren syndrome | 1.900 | 2.7e-05 |
| psoriasis | 1.600 | 1.6e-10 |
| Rheumatoid arthritis | 1.300 | 8.4e-03 |
| subependymal giant cell astrocytoma | 3.082 | 1.2e-02 |
| tuberculosis and treatment for 3 months | -1.400 | 9.6e-04 |
| Species | Source | Disease |
|---|---|---|
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA |
MGSKDHAVFFREMTQLILNEMPKAGYSSILNDFVESNFFVIDGDSLLVTCLGVKSFKWGQNLHFFYLVEC 1 - 70 YLVDLLSNGGQFTIVFFKDAEYAYFDFPELLSLRTALILHLQHNTNIDVQTEFSGCLSQDWKLFLEQHYP 71 - 140 YFLIVSEEGLSDLQTYLFNFLIIHSWGMKVNVVLSSGHESDTLRFYAYTMESTDRNQTFSKENETVIQSA 141 - 210 YKSLIQHLEEIRVLVLATHFEHLKWNDMMEEAYQTLFLLQHLWSEGSDIQRVLCVTSCSLSLRMYHRVLV 211 - 280 HSNCLSLQEVEDFCRLRCLCVAFQLHLPLSQRACSRVITCSWIRNSDSFLKMNKWCEYFILSNLNVFGCW 281 - 350 NLNLNHVSDLYDEQLLKNIAFYYEFESTQEPHLNLGDSIRRDYEDLWNVVSHLVKEFNVGKSFPLRTTRR 351 - 420 HFLRQEKSVIQEISLEKMPSVGFIPMTSAVIDEFVGDMMKDLPILKSDDPVVPSLFKQKTSDELLHWHAQ 421 - 490 RLLSDDYDRIKCHVDEQSRDPHVLDFLKKIQDYQQFYGKSLESISTKVIVTQTTRPKEDSSGASGEILQN 491 - 560 TKPHQITKKSKKKSFLKEDQNKAQQNDDLLFSIEEEMKNNLHSGIRKLEDYLTSCASNSVKFGVEMLGLI 561 - 630 ACFKAWKKHCRGEGKISKDLSIAVQMMKRIHSLLERYPEILEAEHHQYIAKCLKYLGFNDLANSLDPTLI 631 - 700 GDDKNKKKYSIDIGPARFQLQYMGHYLIRDERKDRDPRVQDFIPNAWQQELLDVVDKNESAVIVAPTSSG 701 - 770 KTYASYYCMEKVLRESDVGVVVYVAPAKSLVGQVAATVENRFTKTLPAGRTLCGAFTRDYCHNVLNCQVL 771 - 840 ITVPECFEILLLAPHRQKWVERIRYVIFDEVHYLGREVGAKFWELLLVIIRCPFLVLSATINNPNLLTKW 841 - 910 LQSVKQYWKQADKIMEEKCISEKQADKCLNFLQDHSYKNQSYEVRLVLYGERYNDLEKHICSVKHDDVYF 911 - 980 DHFHPCAALTTDIIEKYGFPPDLTLTPQESIQLYDTMAQVWETWPRAQELCPEEFILFKNKIVIKKLDAR 981 - 1050 KYEENLKAELTNWIKNGQVKKVKRVLKNLSPDSLSSSKDMVKMFPLLVEKLRQMDKLPAIFFLFKNDDVG 1051 - 1120 KRAGSVCTFLEKTETKSHPHTECHSYVFAIDEVLEKVRKTQKRITKKNPKKAEKLERKKVYRAEYINFLE 1121 - 1190 NLKILEISEDCTYADVKALHTEITRNKDSTLERVLPRVRFTRHGKELKALAQRGIGYHHSSMYFKEKEFV 1191 - 1260 EILFVKGLIRVVTATETLALGIHMPCKSVVFAQDSVYLDALNYRQMSGRAGRRGQDLLGNVYFFDIPLPK 1261 - 1330 IKRLLASSVPELRGQFPLSITLVLRLMLLASKGDDPEDAKAKVLSVLKHSLLSFKRRRAMETLKLYFLFS 1331 - 1400 LQLLIKEDYLNKKGNPKKFAGLASYLHGHEPSNLVFVNFLKRGLFHNLCKPAWKGSQQFSQDVMEKLVLV 1401 - 1470 LANLFGRKYIPAKFQNANLSFSQSKVILAELPEDFKAALYEYNLAVMKDFASFLLIASKSVNMKKEHQLP 1471 - 1540 LSRIKFTGKECEDSQLVSHLMSCKKGRVAISPFVCLSGNTDNDLLRPETINQVILRTVGVSGTQAPLLWP 1541 - 1610 WKLDNRGRRMPLNAYVLNFYKHNCLTRLDQKNGMRMGQLLKCLKDFAFNIQAISDSLSELCENKRDNVVL 1611 - 1680 AFKQLSQTFYEKLQEMQIQMSQNHLE 1681 - 1706 //
