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Tdark Probable ATP-dependent RNA helicase DDX60-like

This gene encodes a member of the DExD/H-box helicase family of proteins, a subset of the super family 2 helicases. Members of the DExD/H-box helicase family share a conserved functional core comprised of two RecA-like globular domains. These domains contain conserved motifs that mediate ATP binding, ATP hydrolysis, nucleic acid binding, and RNA unwinding. In addition to functions in RNA metabolism, members of this family are involved in anti-viral immunity and act as cytosolic sensors of viral nucleic acids. The protein encoded by this gene has been shown to inhibit hepatitis C virus replication in response to interferon stimulation in cell culture. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

 Comments

Property Summary

NCBI Gene PubMed Count 5
PubMed Score 0.83
PubTator Score 0.67

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count Z-score Confidence
Liver disease 219 0.0 1.0

Expression

  Differential Expression (21)

Disease log2 FC p
Rheumatoid Arthritis 1.300 8.4e-03
osteosarcoma -1.440 7.8e-03
posterior fossa group B ependymoma 1.600 8.0e-06
glioblastoma 1.800 2.2e-06
atypical teratoid / rhabdoid tumor 2.100 8.3e-03
juvenile dermatomyositis 2.083 2.0e-15
tuberculosis and treatment for 6 months -2.200 1.0e-03
intraductal papillary-mucinous adenoma (... 2.200 2.0e-04
intraductal papillary-mucinous carcinoma... 1.500 5.4e-03
intraductal papillary-mucinous neoplasm ... 2.000 4.6e-03
pancreatic cancer 1.100 8.8e-05
diabetes mellitus -1.100 8.0e-03
cystic fibrosis 1.300 2.1e-02
adult high grade glioma 1.700 5.3e-05
pilocytic astrocytoma 1.800 2.4e-07
primary Sjogren syndrome 1.900 2.7e-05
subependymal giant cell astrocytoma 3.082 1.2e-02
nasopharyngeal carcinoma 1.200 1.6e-03
psoriasis 1.900 2.2e-61
lung carcinoma -2.000 3.2e-21
ovarian cancer -2.400 4.4e-08

Synonym

Accession Q5H9U9 Q96ND6
Symbols

Gene

DDX60L

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (9)

 GO Function (3)

 Compartment GO Term (3)

 GWAS Trait (1)

 HCA RNA Cell Line (56)

See all...

Gene RIF (2)

PMID Text
26269178 DDX60L is an interferon-gamma stimulated gene product restricting Hepatitis C virus replication in cell culture.
18976975 Knockdown of DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like (DDX60L) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells

AA Sequence 

MGSKDHAVFFREMTQLILNEMPKAGYSSILNDFVESNFFVIDGDSLLVTCLGVKSFKWGQNLHFFYLVEC      1 - 70
YLVDLLSNGGQFTIVFFKDAEYAYFDFPELLSLRTALILHLQHNTNIDVQTEFSGCLSQDWKLFLEQHYP     71 - 140
YFLIVSEEGLSDLQTYLFNFLIIHSWGMKVNVVLSSGHESDTLRFYAYTMESTDRNQTFSKENETVIQSA    141 - 210
YKSLIQHLEEIRVLVLATHFEHLKWNDMMEEAYQTLFLLQHLWSEGSDIQRVLCVTSCSLSLRMYHRVLV    211 - 280
HSNCLSLQEVEDFCRLRCLCVAFQLHLPLSQRACSRVITCSWIRNSDSFLKMNKWCEYFILSNLNVFGCW    281 - 350
NLNLNHVSDLYDEQLLKNIAFYYEFESTQEPHLNLGDSIRRDYEDLWNVVSHLVKEFNVGKSFPLRTTRR    351 - 420
HFLRQEKSVIQEISLEKMPSVGFIPMTSAVIDEFVGDMMKDLPILKSDDPVVPSLFKQKTSDELLHWHAQ    421 - 490
RLLSDDYDRIKCHVDEQSRDPHVLDFLKKIQDYQQFYGKSLESISTKVIVTQTTRPKEDSSGASGEILQN    491 - 560
TKPHQITKKSKKKSFLKEDQNKAQQNDDLLFSIEEEMKNNLHSGIRKLEDYLTSCASNSVKFGVEMLGLI    561 - 630
ACFKAWKKHCRGEGKISKDLSIAVQMMKRIHSLLERYPEILEAEHHQYIAKCLKYLGFNDLANSLDPTLI    631 - 700
GDDKNKKKYSIDIGPARFQLQYMGHYLIRDERKDRDPRVQDFIPNAWQQELLDVVDKNESAVIVAPTSSG    701 - 770
KTYASYYCMEKVLRESDVGVVVYVAPAKSLVGQVAATVENRFTKTLPAGRTLCGAFTRDYCHNVLNCQVL    771 - 840
ITVPECFEILLLAPHRQKWVERIRYVIFDEVHYLGREVGAKFWELLLVIIRCPFLVLSATINNPNLLTKW    841 - 910
LQSVKQYWKQADKIMEEKCISEKQADKCLNFLQDHSYKNQSYEVRLVLYGERYNDLEKHICSVKHDDVYF    911 - 980
DHFHPCAALTTDIIEKYGFPPDLTLTPQESIQLYDTMAQVWETWPRAQELCPEEFILFKNKIVIKKLDAR    981 - 1050
KYEENLKAELTNWIKNGQVKKVKRVLKNLSPDSLSSSKDMVKMFPLLVEKLRQMDKLPAIFFLFKNDDVG   1051 - 1120
KRAGSVCTFLEKTETKSHPHTECHSYVFAIDEVLEKVRKTQKRITKKNPKKAEKLERKKVYRAEYINFLE   1121 - 1190
NLKILEISEDCTYADVKALHTEITRNKDSTLERVLPRVRFTRHGKELKALAQRGIGYHHSSMYFKEKEFV   1191 - 1260
EILFVKGLIRVVTATETLALGIHMPCKSVVFAQDSVYLDALNYRQMSGRAGRRGQDLLGNVYFFDIPLPK   1261 - 1330
IKRLLASSVPELRGQFPLSITLVLRLMLLASKGDDPEDAKAKVLSVLKHSLLSFKRRRAMETLKLYFLFS   1331 - 1400
LQLLIKEDYLNKKGNPKKFAGLASYLHGHEPSNLVFVNFLKRGLFHNLCKPAWKGSQQFSQDVMEKLVLV   1401 - 1470
LANLFGRKYIPAKFQNANLSFSQSKVILAELPEDFKAALYEYNLAVMKDFASFLLIASKSVNMKKEHQLP   1471 - 1540
LSRIKFTGKECEDSQLVSHLMSCKKGRVAISPFVCLSGNTDNDLLRPETINQVILRTVGVSGTQAPLLWP   1541 - 1610
WKLDNRGRRMPLNAYVLNFYKHNCLTRLDQKNGMRMGQLLKCLKDFAFNIQAISDSLSELCENKRDNVVL   1611 - 1680
AFKQLSQTFYEKLQEMQIQMSQNHLE                                               1681 - 1706
//

Text Mined References (7)

PMID Year Title
26269178 2015 DDX60L Is an Interferon-Stimulated Gene Product Restricting Hepatitis C Virus Replication in Cell Culture.
23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
20708005 2010 Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease.
17974005 2007 The full-ORF clone resource of the German cDNA Consortium.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15815621 2005 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.