Tbio DDI2 Protein DDI1 homolog 2

Protein Summary

Description

Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane (PubMed:27676298, PubMed:27528193). Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1 (PubMed:27528193).

Uniprot Accession IDs

• Q5TDH0
• A8KAE1
• Q7RTZ0
• Q9BRT1

Gene Name

• DDI2

Ensembl ID

• ENST00000480945
• ENSP00000417748
• ENSG00000197312

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein) perturbation	0.83
cell type or tissue	0.68
histone modification site profile	0.68
transcription factor binding site profile	0.67
tissue sample	0.65

Protein Classes

PANTHER Classes

Protein / ... / Aspartic Protease / Protein Ddi1 Homolog 2

DTO Classes

Protein / Enzyme / Protease / Aspartic Protease / Protein Ddi1 Homolog 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.87   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 91   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.87   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0