Tbio DCTN4 Dynactin subunit 4

Protein Summary

Description

Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.

Uniprot Accession IDs

• Q9UJW0
• B3KWW0
• D3DQH0
• E5RGT5
• Q8TAN8
• Dyn4

Gene Name

• DCTN4

Ensembl ID

• ENST00000424236
• ENSP00000411251
• ENSG00000132912
• ENST00000446090
• ENSP00000414906
• ENST00000447998
• ENSP00000416968

Symbol

• P62
• DYN4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.85
histone modification site profile	0.8
kinase perturbation	0.76
transcription factor perturbation	0.74
cellular component	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.28   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 206   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.28   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0