Tbio DCANP1 Dendritic cell nuclear protein 1

Protein Summary

Description

Binds with and transactivates the corticotropin-releasing hormone (CRH) promoter. This intronless gene is specifically expressed in dendritic cells (DCs), which are potent antigen-presenting cells involved in activating naive T cells to initiate antigen-specific immune response. The encoded protein is localized mainly in the perinucleus. One of the alleles (A/T) of this gene, that causes premature translation termination at aa 117, has been associated with an increased prevalence of major depression in humans. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8TF63

Gene Name

• DCANP1

Ensembl ID

• ENST00000503143
• ENSP00000421871
• ENSG00000251380

Symbol

• C5orf20
• DCNP1
• DCNP1
• C5orf20

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.66
cell line	0.53
tissue sample	0.47
biological process	0.41
chemical	0.41

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.92   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 31   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.92   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0