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Tbio
DCAF11
DDB1- and CUL4-associated factor 11

Protein Summary
Description
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396936
  • ENSP00000380142
  • ENSG00000100897
  • ENST00000396941
  • ENSP00000380146
  • ENST00000446197
  • ENSP00000415556
  • ENST00000559115
  • ENSP00000452898
  • ENST00000642239
  • ENSP00000494282
  • ENSG00000284796
  • ENST00000644566
  • ENSP00000493711
  • ENST00000646524
  • ENSP00000495415
  • ENST00000646568
  • ENSP00000495416

Symbol
  • WDR23
  • GL014
  • WDR23
  • PRO2389
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.93
disease perturbation
0.9
kinase perturbation
0.81
histone modification site profile
0.77
transcription factor
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.52   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.52   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0