Tbio DAZAP2 DAZ-associated protein 2

Protein Summary

Description

This gene encodes a proline-rich protein which interacts with the deleted in azoospermia (DAZ) and the deleted in azoospermia-like gene through the DAZ-like repeats. This protein also interacts with the transforming growth factor-beta signaling molecule SARA (Smad anchor for receptor activation), eukaryotic initiation factor 4G, and an E3 ubiquitinase that regulates its stability in splicing factor containing nuclear speckles. The encoded protein may function in various biological and pathological processes including spermatogenesis, cell signaling and transcription regulation, formation of stress granules during translation arrest, RNA splicing, and pathogenesis of multiple myeloma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• Q15038
• A8K254
• B4DDT5
• B4E1G3
• C9JA96
• C9JP84
• E9PB45
• F8VU62

Gene Name

• DAZAP2

Ensembl ID

• ENST00000412716
• ENSP00000394699
• ENSG00000183283
• ENST00000425012
• ENSP00000408251
• ENST00000439799
• ENSP00000398804
• ENST00000449723
• ENSP00000412812
• ENST00000549555
• ENSP00000448051
• ENST00000549732
• ENSP00000446554

Symbol

• KIAA0058
• PRTB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	1
virus perturbation	0.99
microRNA	0.87
transcription factor perturbation	0.84

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.53   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 101   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.53   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0