| Tbio | Disabled homolog 1 |
Adapter molecule functioning in neural development. May regulate SIAH1 activity.
The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. [provided by RefSeq, Jan 2017]
The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. [provided by RefSeq, Jan 2017]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Autistic Disorder | 364 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| osteosarcoma | 7950 | 3.6e-07 |
| atypical teratoid / rhabdoid tumor | 5112 | 4.7e-04 |
| group 3 medulloblastoma | 4104 | 6.3e-04 |
| oligodendroglioma | 2850 | 1.1e-03 |
| astrocytic glioma | 2597 | 1.1e-03 |
| adult high grade glioma | 3801 | 1.1e-03 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 2.7e-03 |
| interstitial cystitis | 2312 | 2.7e-03 |
| ependymoma | 4679 | 3.2e-03 |
| glioblastoma | 5792 | 3.5e-03 |
| medulloblastoma, large-cell | 6241 | 6.4e-03 |
| subependymal giant cell astrocytoma | 2287 | 2.4e-02 |
| Breast cancer | 3578 | 3.1e-02 |
| lung cancer | 4740 | 4.4e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Acquired immunodeficiency syndrome | 197 | 0.0 | 0.7 |
| Alzheimer's disease | 658 | 0.0 | 0.8 |
| Anorexia nervosa | 80 | 0.0 | 1.4 |
| Kawasaki disease | 28 | 0.0 | 1.7 |
| Motor neuron disease | 49 | 0.0 | 1.1 |
| Vascular disease | 319 | 0.0 | 0.8 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Neurodegenerative disease | 414 | 0.0 | 4.0 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -2.300 | 1.1e-03 |
| astrocytic glioma | -2.200 | 1.1e-03 |
| atypical teratoid / rhabdoid tumor | -2.200 | 4.7e-04 |
| Breast cancer | -2.100 | 3.1e-02 |
| ependymoma | -2.400 | 3.2e-03 |
| glioblastoma | -1.600 | 3.5e-03 |
| group 3 medulloblastoma | 1.600 | 6.3e-04 |
| interstitial cystitis | -2.100 | 2.7e-03 |
| intraductal papillary-mucinous adenoma (... | -1.100 | 2.7e-03 |
| lung cancer | -1.100 | 4.4e-02 |
| medulloblastoma, large-cell | 1.200 | 6.4e-03 |
| oligodendroglioma | -2.000 | 1.1e-03 |
| osteosarcoma | 1.176 | 3.6e-07 |
| subependymal giant cell astrocytoma | -2.665 | 2.4e-02 |
MSTETELQVAVKTSAKKDSRKKGQDRSEATLIKRFKGEGVRYKAKLIGIDEVSAARGDKLCQDSMMKLKG 1 - 70 VVAGARSKGEHKQKIFLTISFGGIKIFDEKTGALQHHHAVHEISYIAKDITDHRAFGYVCGKEGNHRFVA 71 - 140 IKTAQAAEPVILDLRDLFQLIYELKQREELEKKAQKDKQCEQAVYQTILEEDVEDPVYQYIVFEAGHEPI 141 - 210 RDPETEENIYQVPTSQKKEGVYDVPKSQPVSNGYSFEDFEERFAAATPNRNLPTDFDEIFEATKAVTQLE 211 - 280 LFGDMSTPPDITSPPTPATPGDAFIPSSSQTLPASADVFSSVPFGTAAVPSGYVAMGAVLPSFWGQQPLV 281 - 350 QQQMVMGAQPPVAQVMPGAQPIAWGQPGLFPATQQPWPTVAGQFPPAAFMPTQTVMPLPAAMFQGPLTPL 351 - 420 ATVPGTSDSTRSSPQTDKPRQKMGKETFKDFQMAQPPPVPSRKPDQPSLTCTSEAFSSYFNKVGVAQDTD 421 - 490 DCDDFDISQLNLTPVTSTTPSTNSPPTPAPRQSSPSKSSASHASDPTTDDIFEEGFESPSKSEEQEAPDG 491 - 560 SQASSNSDPFGEPSGEPSGDNISPQAGS 561 - 588 //
