| Tdark | Ubiquitin carboxyl-terminal hydrolase 17-like protein 21 |
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.
Comments
MEEDSLYLGGEWQFNHFSKLTSSRPDAAFAEIQRTSLPEKSPLSCETRVDLCDDLAPVARQLAPREKLPL 1 - 70 SNRRPAAVGAGLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRHKGCMLCTMQAHITRALHNPG 71 - 140 HVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMKKACLPGHKQVDHHSKDTTLIHQIFGGYWRSQIKCLHC 141 - 210 HGISDTFDPYLDIALDIQAAQSVQQALEQLVKPEELNGENAYHCGVCLQRAPASKMLTLLTSAKVLILVL 211 - 280 KRFSDVTGNKIAKNVQYPECLDMQPYMSQPNTGPLVYVLYAVLVHAGWSCHNGHYFSYVKAQEGQWYKMD 281 - 350 DAEVTASSITSVLSQQAYVLFYIQKSEWERHSESVSRGREPRALGAEDTDRRATQGELKRDHPCLQAPEL 351 - 420 DEHLVERATQESTLDHWKFLQEQNKTKPEFNVRKVEGTLPPDVLVIHQSKYKCGMKNHHPEQQSSLLNLS 421 - 490 SSTPTHQESMNTGTLASLRGRARRSKGKNKHSKRALLVCQ 491 - 530 //
| PMID | Year | Title |
|---|---|---|
| 21448158 | 2011 | The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility. |
| 21239494 | 2011 | Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity. |
| 20715989 | 2010 | Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme. |
| 20403174 | 2010 | The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster. |
| 20388806 | 2010 | The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression. |
| 20368735 | 2010 | The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling. |
| 20228808 | 2010 | Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A. |
| 20228807 | 2010 | Cdc25A and Dub3 in a high-stakes balancing act. |
| 20147298 | 2010 | The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected. |
| 19188362 | 2009 | USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity. |
| More... |
