1. Home
  2. Targets
  3. Ubiquitin carboxyl-terminal hydrolase 17-like protein 21

Tdark Ubiquitin carboxyl-terminal hydrolase 17-like protein 21

Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.

 Comments

Property Summary

NCBI Gene PubMed Count 17
PubMed Score 0.00

Knowledge Summary

Patent

No data available

Expression

Synonym

Accession D6R901
Symbols

Gene

USP17L21

 GO Function (1)

 GO Component (2)

 GO Process (2)

 Compartment GO Term (14)

Pathway (4)

 UniProt Keyword (8)

AA Sequence 

MEEDSLYLGGEWQFNHFSKLTSSRPDAAFAEIQRTSLPEKSPLSCETRVDLCDDLAPVARQLAPREKLPL      1 - 70
SNRRPAAVGAGLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRHKGCMLCTMQAHITRALHNPG     71 - 140
HVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMKKACLPGHKQVDHHSKDTTLIHQIFGGYWRSQIKCLHC    141 - 210
HGISDTFDPYLDIALDIQAAQSVQQALEQLVKPEELNGENAYHCGVCLQRAPASKMLTLLTSAKVLILVL    211 - 280
KRFSDVTGNKIAKNVQYPECLDMQPYMSQPNTGPLVYVLYAVLVHAGWSCHNGHYFSYVKAQEGQWYKMD    281 - 350
DAEVTASSITSVLSQQAYVLFYIQKSEWERHSESVSRGREPRALGAEDTDRRATQGELKRDHPCLQAPEL    351 - 420
DEHLVERATQESTLDHWKFLQEQNKTKPEFNVRKVEGTLPPDVLVIHQSKYKCGMKNHHPEQQSSLLNLS    421 - 490
SSTPTHQESMNTGTLASLRGRARRSKGKNKHSKRALLVCQ                                  491 - 530
//

Text Mined References (18)

PMID Year Title
21448158 2011 The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.
21239494 2011 Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.
20715989 2010 Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme.
20403174 2010 The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.
20388806 2010 The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.
20368735 2010 The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.
20228808 2010 Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.
20228807 2010 Cdc25A and Dub3 in a high-stakes balancing act.
20147298 2010 The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.
19188362 2009 USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.
More...