Property Summary

NCBI Gene PubMed Count 188
PubMed Score 298.74
PubTator Score 286.29

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count Z-score Confidence
Cancer 2346 4.313 2.2

Expression

  Differential Expression (37)

Gene RIF (169)

PMID Text
26923924 we demonstrate that NF2 negatively controls the invasiveness of Glioblastoma multiforme through YAP-dependent induction of CYR61/CCN1 and miR-296-3p.
26630293 up-regulated in epithelial cells of salivary glands of primary Sjogren's syndrome patients
26498181 Studies indicate that the CYR61 CTGF NOV matricellular proteins (CCN family of proteins) comprises the members CCN1, CCN2, CCN3, CCN4, CCN5 and CCN6 and have been identified in various types of cancer.
26459773 Data show that RNA silencing of CCN family member 1 protein (CCN1) inhibits umbilical vein endothelial cell (HUVEC) proliferation under hypoxic conditions by inhibiting phosphoinositide 3-kinase (PI3K)/AKT protein signaling.
26424659 Report shows evidence that CCN1 is O-fucosylated at Threonine 242 and that O-fucosylation of CCN1 regulates its secretion.
26203933 The expression of CYR61,that regulates fibroblast-like synoviocites proliferation and T helper 17 cell differentiation,appears to be crucial in mediating joint inflammation in Rheumatoid arthritis.
26201842 It promotes cell growth and angiogenesis in cancers through its interaction with several integrins and proved to be an independent prognostic factor for patient survival.
26028023 CCN1 is an injury response protein that functions not only to restrict fibrosis in the liver, but also to suppress hepatocarcinogenesis by inhibiting EGFR-dependent hepatocyte compensatory proliferation
25980494 c-Src regulates secreted proteins, including the exosomal Cyr61, which are involved in modulating the metastatic potential of triple negative breast cancer cells.
25974135 SYK is downstream of CYR61 and contributes to CYR61-mediated mitoxantrone resistance. The CYR61-SYK pathway represents a potential target for reducing stroma-induced chemoresistance
25854342 Overexpression of Cyr61 may induce epithelial-mesenchymal transition and therefore leads to laryngeal squamous- cell carcinoma invasion and metastasis and poor prognosis.
25822023 CCN1 is highly elevated in cholangiocytes in human cholestatic liver. CCN1 activates NF-kappaB in differentiated cholangiocytes through integrin alphavbeta5/alphavbeta3, leading to Jag1 expression and JAG1/NOTCH1 signaling to drive cholangiocyte proliferation.
25773758 Results suggest that Cyr61 is induced by EGF through the ERK/CREB signal pathway and that it plays a crucial role in the migration and invasion of anaplastic thyroid cancer cells.
25728492 Cyr61 was higher in RA synovial fluid than in osteoarthritis synovial fluid. Cyr61 induced proIL-1beta production in fibroblast-like synoviocytes via the AKT-dependent NF-kappaB signaling pathway.
25709087 CCN1 suppresses ADAMTS-4 activity and that CCN1 overexpression is directly correlated with chondrocyte cloning in osteoarthritis cartilage. The TGFbeta/CCN1 axis plays a role in chondrocyte cluster formation through inhibition of ADAMTS-4.
25620088 Cyr61 promotes CD204 expression and the migration of macrophages via MEK/ERK pathway in esophageal squamous cell carcinoma
25536346 Reactive oxygen species increased c-Jun, a critical member of transcription factor AP-1 complex, and increased c-Jun binding to the AP-1 site of the CCN1 promoter.
25501701 our findings suggest a potential role of Cyr61 in GBM growth and highlight Cyr61 as a novel target for glioblastoma therapy
25421497 endothelial CCN1 downregulation at least partially due to Fli1 deficiency may contribute to the development of digital ulcers in systemic sclerosis patients
25329584 potential role of Cyr61 in Muller cell degeneration
25326651 Cyr61 promotes the Epithelial to mesenchymal transition (EMT) of osteosarcoma cells by regulating EMT markers via a signal transduction pathway.
25135600 Report is first to suggest a relationship between a genetic variant p.R47W in CCN1 and atrial septal defects in humans.
25104090 Overexpression of Cyr61 enhanced the growth of pancreatic carcinoma via nuclear exclusion of p27.
25061178 CYR61/CCN1 overexpression in the myeloma microenvironment is associated with superior survival and reduced bone disease.
25059387 results suggest a previously unknown Sox4-Cyr61 molecular network, which may control colon cancer cell proliferation and survival
25048722 CYR61 overexpression associated with the development and poor prognosis of ovarian carcinoma.
24973403 we hypothesize that cCCN1 promoted the epithelial cell death and tissue loss after prolonged cigarette smoking exposure
24909560 integrin alpha(v) beta(3) and AMP-Activated Protein Kinases mediate CCN1-induced endothelial cell migration and tube formation independent of intracellular ATP levels alteration.
24895995 Findings reveal that CCN1 plays a novel role in pathogen clearance; increasing macrophage infiltration and activation resulting in increased virus clearance in tumors.
24780075 An association with Graves disease was shown for SNP rs3753793 in CYR61. An association with Graves ophthalmopathy was shown for several SNPs. Smoking and CYR61 rs12756618 interacted to increase the risk of Graves ophthalmopathy.
24767859 Our results suggest that CCN1 has a role in the development of intraepithelial breast carcinoma.
24606730 Our data confirmed that Cyr61 was expressed in colorectal cancers and the expression was correlated with worse prognosis of colorectal cancers.
24595148 CYR61 expression was significantly upregulated in ovarian carcinoma tissue compared with benign ovarian tumour tissue samples. Protein CYR61 levels were associated with lymph node metastases and Union for International Cancer Control stage.
24517278 Our results here reveal a novel role of Cyr61 in the pathogenesis of rheumatoid arthritis
24485923 we report that YAP and its downstream transcriptional targets CCN1 and CCN2 are markedly elevated in keratinocytes in human skin basal cell carcinoma
24449575 Results reveal a novel mechanism whereby p53 is involved in the posttranscriptional regulation of Cyr61 expression via miRNA-22.
24430538 It provides evidence that CCN1 is released from activated platelets, suggesting that platelets constitute a novel source for CCN1 release to the circulation during sepsis.
24317814 our results further revealed that expression of Cyr61, an extracellular matrix-associated growth factor, was negatively regulated by miR-100.
24084383 Overexpression of MRTF-A significantly promoted the migration of MCF-7 cells through its transactivation effects on MYL9 and CYR61 genes
24037310 overexpressed Cyr61 plays a key role in the metastasis of osteosarcoma cells and Cyr61 is a potential target downstream of TGF-beta/p38 MAPK to regulate cell migration.
24009013 target for heparin binding, which interferes with integrin functions
23798676 Degradome products of the matricellular protein CCN1 as modulators of pathological angiogenesis in the retina.
23744557 Vinblastine resistance in renal cell carcinoma can be ascribed to the overexpression of P-gp, which is regulated by the activation of the PI3K/Akt pathway and triggered by upstream CCN1-integrin avb3 interaction.
23623839 data indicate that PC-3 cells overproduce Cyr61 protein via activation of the PI3K/Akt signaling as a part of the survival mechanisms under the conditions causing extracellular acidity and further cytotoxicity
23618859 Data indicate CCN1 can induce actin reorganization, formation of lamellipodia, and cell migration/invasion through the alphaV integrins/Rac1/ERK signaling axis; these CCN1-dependent activities can be effectively suppressed by monoclonal antibody YM1B.
23528710 Cyr61/Caprin-1 co-expression was associated with worse survival.
23504324 domain-specific interactions of CCN1 with alphaVbeta3 integrin contribute to human skin aging by stimulating MMP-1-mediated collagen fibril fragmentation.
23316072 Beta-catenin-dependent expression of WISP1 and Cyr61 is critical for epithelial repair.
23259998 Cyr61 induces angiogenetic effect and enhances the tumorigenicity of solid tumors.
23196056 Snail-dependent production of Cyr61 in epithelial mesenchymal transformation-phenotypic cells could prime and promote dynamic cell migration of the invasive tumor nest.
23141184 Blocking the PI3K signal pathway could significantly inhibit the expression of Cyr61, and may promote the apoptotic effects and inhibit cell growth of ovarian carcinoma cells.
23045290 Our results indicate that the genetic variation of rs3753793 in the CYR61 promoter may contribute to genetic predisposition to prostate cancer
23027863 the matricellular protein CCN1/Cyr61 is a critical regulator of Sonic Hedgehog in pancreatic carcinogenesis
22752926 CCN1 is upregulated in pancreatic cancer and promotes the survival of pancreatic cancer cells.
22694338 Wnt-5a and CYR61 are enriched in the extracellular matrix of liver fibrotic tissue compared with control matrix.
22692860 Data indicate the role of CYR61 and alpha(V)beta5 integrin as proteins that cooperate to mediate cancer cell migration.
22566095 Given the ability of CCN1 to regulate both production and degradation of type I collagen, it is likely that elevated-CCN1 functions as an important mediator of collagen loss, which is observed in aged human skin.
22551568 cysteine-rich angiogenic inducer 61 may promote trophoblast cell migration and invasion through upregulation of NUR77 protein leading to the increase of matrix metalloproteinase 2(MMP2) release and the downregulation of tissue inhibitor of MMP2 expression
22547695 Cyr61 stimulates interleukin (IL)-6 production by fibroblast-like synoviocytes via the integrin avbeta5/Akt/NF-kappaB signaling pathway in rheumatoid arthritis, while the increased IL-6 in turn promotes T helper (Th)17 cell differentiation.
22540002 Over-expression of Cyr61 was positively correlated with increased levels of beta-catenin in human HCC samples.
22532143 It conclude that in the murine atria, CCN1 and CCN2 proteins are expressed constitutively. In chronic heart failure, CCN proteins tend to be upregulated, which may be related to the action of angiotensin II.
22527715 CCN1 plays an important role in regulating immune cell trafficking by attracting and locally immobilizing immune cells
22401280 EGF-mediated CYR61 upregulation in HES cells involves STAT3 and is counter-regulated by the EGFR/MAPK/ERK pathway.
22363611 CCN1 promotes the activation of p53 and p38 MAPK, which mediate enhanced cytochrome c release to amplify the cytotoxicity of TNFalpha.
22253074 Cyr61 enhances the migration of oral squamous cell carcinoma cells by increasing MMP-3 expression through the alphavbeta3 or alpha6beta1 integrin receptor, FAK, MEK, ERK, and NF-kappaB signal transduction pathway
22160564 CYR61 are likely to be involved in the pathogenesis of diabetic retinopathy, and may play a role in the course of neovasculation.
22056874 a novel, VEGF-independent, clinically relevant, pro-angiogenic factor, CYR61, that is a transcriptional target of Hh-GLI signaling
22025384 Circulating Cyr61 levels are a potential serum-based biomarker that correlates with prostate cancer aggressiveness.
22023263 Study demonstrates that CYR61 protein enhances the expression of VEGFC by binding with alphaVbeta3 integrin receptor on the surface of Decidual natural killer (dNK) cells through intracellular PI3K/AKT signaling pathway; may regulate the function of dNK cells and may be operative in the pathogenesis of pre-eclampsia.
21995436 Egr-1-dependent induction of Cyr61 may contribute to premature skin ageing by smoking.
21976359 Cyr61 has considerable potential as a novel marker for poor prognosis in osteosarcoma.
21711965 induced by hypoxia in nasal polyp fibroblasts
21628462 KLK12 may indirectly regulate the bioavailability and activity of several growth factors through processing of their CCN binding partners
21618249 High serum CYR61 is associated with gastric cancer.
21601497 Cyr61 appeared to have a significant association with tumor angiogenesis and metastasis in SACC and may be an important target in tumor antiangiogenesis therapy.
21505992 Cyr61 is transcriptionally induced under hypoxia and is an important factor in preeclampsia.
21488975 The mechanism by which retinoids such as vitamin A improve aged skin, through increased collagen production, involves down-regulation of CCN1.
21447598 Expression of tumor-promoting Cyr61 is regulated by hTRA2-beta1 and acidosis.
21397653 Chlorella-derived peptide inhibits UVB-induced MMP-1 expression in skin fibroblasts by suppressing expression of AP-1 and CYR61 and MCP-1 production.
21393426 Zoledronic acid targets the proangiogenic factor (CCN1) through FOXO3a and reveals a new mechanism of ZOL action in breast cancer cells.
21349946 Findings define the TAZ-TEAD-Cyr61/CTGF signaling pathway as an important modifier of the Taxol response in breast cancer cells.
21312266 Cyr61 expression increases with tumor grade in human osteosarcoma and demonstrate that cyr61 silencing inhibits in vitro osteosarcoma cell invasion and migration as well as in vivo lung metastases in mice.
21249313 Cyr61 may play crucial roles in regulating neoplasm progression of ESCC.
21232118 Cyr61/CCN1 signaling is critical for epithelial-mesenchymal transition and stemness and promotes pancreatic carcinogenesis
21212405 Galpha(12/13) regulate AP-1-dependent CYR61 induction in vascular smooth muscle, promoting migration, and they are upregulated with CYR61 in arteriosclerotic lesions.
21159247 The expressions of Cyr61 and/or WISP-3 may be important biological markers in reflecting the progression, biological behaviors, metastatic potential and prognosis of NSCLC.
21153366 extracellular matrix protein CCN1 dictates TNFalpha and FasL cytotoxicity
21138874 Cyr61 may serve as a tissue biomarker for stratifying men for risk of recurrence in prostate cancer.
21081514 Upregulation of Cyr61 and CTGF gene expression in colorectal cancer suggests they have a role in tumour initiation or development but not as highly expressed in advanced stages suggesting their role may be important at an early stage of tumour development
20641097 Cyr61 plays a role in the development of the external genitalia, but we could not confirm that mutations affecting the CYR61 gene are a frequent cause of epispadias or classic bladder exstrophy.
20628624 Meta-analysis of gene-disease association. (HuGE Navigator)
20531301 Inhibition of AP-1 by SARI negatively regulates transformation progression mediated by CCN1.
20237496 Observational study of gene-disease association. (HuGE Navigator)
20237132 CYR61 and NOV are regulated by HIF-1alpha and TGF-beta3 in the trophoblast cell line JEG3, and their enhanced secretion could be implicated in appropriate placental invasion.
20233866 Results identify a Cyr61-dependent pathway by which c-Met activation mediates cell growth, cell migration, and long-lasting signaling events in glioma cell lines and possibly astroglial malignancies.
20195466 Data reveal that multimeric VTNC attenuate Cyr61 binding to immobilized VTNC, while monomeric VTNC was ineffective.
20097175 this study identified CCN1 as a key molecule in gastro-esophageal reflux disease due to low pH and its progression towards esophageal adenocarcinoma.
20056838 Fascin regulates the proliferation and invasiveness of ESCC cells by modulating the expression of CTGF and CYR61 via TGF-beta pathway.
20043874 The data show that sclerostin binds to and influences the activity of Cyr61.
20010302 The angiogenic gene CCN1/CYR61 was specifically upregulated in the plexiform neurofibromas.
19950293 Cyr61 plays a critical role in IL-17-mediated proliferation of fibroblast-like synoviocytes in rheumatoid arthritis.
19632997 CREB promotes melanoma growth and metastasis by down-regulating CCN1/CYR61 expression, which acts as a suppressor of melanoma cell motility, invasion and angiogenesis.
19584265 Findings reveal a functional dichotomy for CCN1 in prostate carcinoma cells, because it contributes to both cell proliferation and TRAIL-induced cell death.
19542562 Data suggest that signal-controlled activation of SRF, MRTF-A, and CBP provides a novel connection between mechanical stimuli and CCN1 gene expression.
19364818 CCN1 activates neutral sphingomyelinase, which functions as a key source of CCN1-induced ROS critical for synergism with FasL.
19288017 SDC2 and CYR61 expression affect the severity of cancer, and the survival of patients with esophageal squamous cell carcinoma (ESCC).
19244129 hypoxia serves as a specific inducer of alternative Cyr61 splicing toward the intron skipping mRNA isoform with potential biological consequences in tumor cells.
19180570 functional link between Cyr61 and p53 in cancers
19147534 The sphingosine-1-phosphate receptor signaling enhances invasiveness in glioblastoma, partially through CCN1.
19007976 Cyr61 is highly expressed in some endometrial cancer of endometrioid subtype. Cyr61 expression and positive lymph node metastases were independent prognostic factors for patients with endometrioid adenocarcinoma.
18950845 Observational study of gene-disease association. (HuGE Navigator)
18941464 Cyr61 played an important role in the tumorigenicity and metastasis of PCa cells.
18936953 plasma membrane S1P(1) receptors are rapidly internalized and subsequently translocated to nuclear compartment upon S1P stimulation; nuclear S1P(1) is able to regulate the transcription of Cyr61 and CTGF
18819928 Overexpression of CCN1 mediated by CREB is enhanced in hypoxic regions of tumors.
18800188 CYR61 prevents cisplatin-induced apoptosis by inhibiting caspase-3 activity in HeLa cells.
18687805 Thrombin receptor and RhoA mediate cell proliferation through integrins and cysteine-rich protein 61.
18599605 SP exposure to human intestinal microvascular endothelial cells co-cultured with NCM460-NK-1R cells induced angiogenic activity that was inhibited by CCN1 silencing.
18575751 The multimodular structure of CCN1 enables it to fulfill multiple functions that may contribute to the different stages of cancer development.
18381294 Cyr61 promoted gastric cancer cell invasive ability via an HIF-1alpha-dependent up-regulation of PAI-1.
18212329 Increased expression of this protein correlates with the loss of VHL protein expression in renal cell carcinoma.
18202125 The opposite effect of TNFalpha combined with hypoxia on CYR61 up-regulation could contribute to a balanced expression level of this angiogenic factor in the endometrium.
18089610 Reduction of CCN1/CCN3 in preeclampsia could be responsible for the failure of uterine vascular remodeling.
18058471 Cyr61 appears to guard against metastatic disease because low expression is associated with more advanced disease; and therefore, expression levels of Cyr61 correlate with the prognosis of lung cancer.
18025257 Cyr61 promotes interleukin-8-dependent chemotaxis, transendothelial migration, and intravasation by induction of CXCR1/CXCR2 through integrin alphavbeta3/Src/PI3K/Akt-dependent pathway.
18004727 CCN1 promotes growth in glioma cells, CCN1-overexpressing C6 cells. In addition to its effect on cell growth, CCN1 also increased the motility of glioma cells in the presence of extracellular substrates such as fibronectin.
17765657 Blocking experiments with the lysophosphatidic acid (LPA) receptor-specific inhibitor Ki16425 suggest a general involvement of LPA receptors in bacteria-triggered CYR61 expression.
17718860 Observational study of gene-disease association. (HuGE Navigator)
17718860 In men & women, rs 3753794 & rs 3753793 (r2 = 0.77) were associated plasma HDL-cholesterol levels. Carriers of A allele for rs 3753794 were more likely to have high plasma HDL-cholesterol levels as compared with G/G homozygotes & A/A homozygotes.
17699553 CCN1 is expressed in podocytes, acts on glomerular cells to modulate glomerular remodeling, and is downregulated in diseased kidneys. Impairment of CCN1 expression in podocytes may contribute to progression of glomerular disease with mesangial expansion.
17673559 Exercise with high mechanical loading induced the expression of Cyr61 in human skeletal muscle.
17626014 VEGF-mediated up-regulation of CCN1 in osteoblasts that attracts endothelial cells and promotes angiogenesis. Such a loop could be operative during fracture healing.
17601910 In normal endometrium Cyr61 expression is highest in proliferatory phase; it is overexpressed in midsecretory phase in polycystic ovary syndrome (PCOS) and endometrial cancer.
17579708 Downregulation of the Cyr61 is associated with lung cancer.
17437852 We found significant differences in gene expression, specifically with a group of genes, including CYR61, known to be responsive to estrogen or to interact with estrogen receptor.
17429007 CCN1 promotes integrin-dependent recruitment of CD34+ progenitor cells to endothelial cells, which may contribute to paracrine effects on angiogenesis and tissue regeneration.
17234971 Experiments using a recombinant mutant human CYR61 promoter-directed reporter gene expression confirmed transcriptional regulation of CYR61 by FOXO3a.
17056474 IGFBP-3, IGFBP-4, and IGFBP-10/CYR61 mRNA levels were up-regulated in Barrett's and tumour tissue of oesophageal adenocarcinoma patients
16877350 These data identify CYR61 as a pivotal regulator of collagen production and degradation in aged and photoaged human skin.
16804865 The 3 most significantly overexpressed genes in rheumatoid arthritis were laeverin, 11beta-hydroxysteroid dehydrogenase type 2 (a steroid pathway enzyme), and cysteine-rich, angiogenic inducer 61 (a known angiogenic factor).
16675545 In early-onset pre-eclamptic placentae, CYR61 was expressed at a significantly lower level compared with normal matched controls, indicating a potential role of this molecule in the pathogenesis of early-onset pre-eclampsia.
16581771 CYR61 is regulated by the Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells.
16243794 Results suggest that CCN1 may play a role in ovarian carcinogenesis by stimulating survival and antiapoptotic signaling pathways.
15961723 Cyr61 expression provides cytoprotection in hyperoxia-induced pulmonary epithelial cell death and that this effect was in part mediated via the Akt signaling pathway
15878827 Recombinant cyr61 was expressed as a fusion protein with the Fc-domain of human IgG and purified using affinity chromatography on protein G-Sepharose columns. rCyr61 stimulated blood vessel formation and cell proliferation.
15782120 Cyr61 gene expression is significantly downregulated in the tumors of hepatocellular carcinoma patients.
15592521 CYR61 is sufficient to promote breast cancer cell proliferation, cell survival, and Taxol resistance.
15564459 new role for cyr61 in HeLa cells infected with Coxsackievirus B3, which is associated with the cell death induced by virus infection
15526358 Cyr61 and CTGF genes may play an important role in hepatocellular carcinogenesis and correlate with recurrence and metastasis of hepatocellular carcinoma
15471875 Cyr61 has a role in suppressing growth of human endometrial cancer cells
15389821 serum growth factors induce the cysteine rich angiogenic inducer 61(CYR61) gene in both prostate stromal and epithelial cells, and CYR61 plays functional roles in cell adhesion, morphology, and proliferation
15077166 Cyr61 activated the beta-catenin/TCF4 complex, which promoted the expression of c-myc and the latter induced expression of p53.
15053922 evidence that adenylate cyclase as well as one or several protein kinases might be involved in the mechanoregulation of Cyr61, CTGF and Nov genes
15044605 Results suggest that Cyr61 may represent a gene characteristic for endometriosis and may play an important role in the development and persistence of endometriotic lesions.
15044484 Cyr61 plays an important role in resistance to chemotherapeutic agent-induced apoptosis in human breast cancer MCF-7 cells by a mechanism involving the activation of the integrins/NF-kappaB/XIAP signaling pathway
15041728 CYR61 and CTGF may play a role in the progression of gliomas; their levels at diagnosis may have prognostic significance.
14988385 Lysophosphatidic acids induce CYR61 by activating G protein-coupled receptors. CYR61 acts as secreted autocrine and/or paracrine mediator in stromal and epithelial hyperplasia. Potential importance of this signaling mechanism in the disease.
12939282 Cyr61 is a hypoxia-inducible angiogenesis factor in malignant melanoma with tumor stage-dependent expression
12899698 The expression of the CYR61 gene depends on the physiologic state of G-actin monomers
12831056 Regulates angiogenesis and endothelial cell function. (review)
12826661 these findings define the T1 sequence in CCN1 as a novel binding motif for integrin alpha 6 beta 1
12736251 CYR61 has an integrin alphaMbeta2 binding site mediating monocyte adhesion
12444554 Cyr61 promotes breast tumorigenesis and cancer progression
12374462 in addition to its proangiogenic activity, Cyr61 may be a novel mediator of progesterone activity in enhancing growth-factor-driven tumor growth in breast cancer.
12364323 role in promoting cell survival and tubule formation in human umbilical vein endothelial cells
12217894 Cyr61 is an early marker of extracellular matrix remodeling in rat bladder cells
12036876 Identification of integrin alpha(M)beta(2) as an adhesion receptor on human peripheral blood monocytes for Cyr61 and connective tissue growth factor: immediate-early gene products expressed in atherosclerotic lesions.
11840342 promotes tumor growth; increased Cyr61 expression is associated with an aggressive phenotype of breast cancer cells
11810026 Organization and expression of the Cyr61 gene in normal human fibroblasts. In serum-stimulated fibroblasts, an alternative RNA containing an in-frame deletion within exon 4 which disrupts the thrombospondin type 1 repeat was detected.
11751417 Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features.

AA Sequence

MSSRIARALALVVTLLHLTRLALSTCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQLNEDCSKTQPC      1 - 70
DHTKGLECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQPNCKHQCTCIDGAVGCIPLCPQELSL     71 - 140
PNLGCPNPRLVKVTGQCCEEWVCDEDSIKDPMEDQDGLLGKELGFDASEVELTRNNELIAVGKGSSLKRL    141 - 210
PVFGMEPRILYNPLQGQKCIVQTTSWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSL    211 - 280
KKGKKCSKTKKSPEPVRFTYAGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMI    281 - 350
QSCKCNYNCPHANEAAFPFYRLFNDIHKFRD                                           351 - 381
//

Text Mined References (189)

PMID Year Title
26923924 2016 Neurofibromatosis 2 (NF2) controls the invasiveness of glioblastoma through YAP-dependent expression of CYR61/CCN1 and miR-296-3p.
26630293 2016 Paeoniflorin ameliorates symptoms of experimental Sjogren's syndrome associated with down-regulating Cyr61 expression.
26498181 2015 Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review).
26459773 2015 CCN1/Cyr61-PI3K/AKT signaling promotes retinal neovascularization in oxygen-induced retinopathy.
26424659 2015 O-Fucosylation of CCN1 is required for its secretion.
26203933 One year in review: the pathogenesis of rheumatoid arthritis.
26201842 2015 Evaluation of extracellular matrix protein CCN1 as a prognostic factor for glioblastoma.
26091039 2015 A Single Kinase Generates the Majority of the Secreted Phosphoproteome.
26028023 2016 The matricellular protein CCN1 suppresses hepatocarcinogenesis by inhibiting compensatory proliferation.
25980494 2015 Cyr61 as mediator of Src signaling in triple negative breast cancer cells.
25974135 2015 Stromal CYR61 Confers Resistance to Mitoxantrone via Spleen Tyrosine Kinase Activation in Human Acute Myeloid Leukaemia.
25854342 2015 Cyr61/CCN1 overexpression induces epithelial-mesenchymal transition leading to laryngeal tumor invasion and metastasis and poor prognosis.
25822023 2015 CCN1 induces hepatic ductular reaction through integrin ?v??-mediated activation of NF-?B.
25773758 2016 Involvement of cysteine-rich protein 61 in the epidermal growth factor-induced migration of human anaplastic thyroid cancer cells.
25728492 2015 Cyr61 participates in the pathogenesis of rheumatoid arthritis by promoting proIL-1? production by fibroblast-like synoviocytes through an AKT-dependent NF-?B signaling pathway.
25709087 2015 CCN1 (Cyr61) Is Overexpressed in Human Osteoarthritic Cartilage and Inhibits ADAMTS-4 (Aggrecanase 1) Activity.
25620088 2015 Cyr61 promotes CD204 expression and the migration of macrophages via MEK/ERK pathway in esophageal squamous cell carcinoma.
25536346 2014 Oxidant exposure induces cysteine-rich protein 61 (CCN1) via c-Jun/AP-1 to reduce collagen expression in human dermal fibroblasts.
25501701 2015 Cyr61 promotes growth of glioblastoma in vitro and in vivo.
25421497 2015 A possible contribution of endothelial CCN1 downregulation due to Fli1 deficiency to the development of digital ulcers in systemic sclerosis.
25329584 2014 Potential role of Cyr61 induced degeneration of human Müller cells in diabetic retinopathy.
25326651 2014 Cyr61 promotes epithelial-mesenchymal transition and tumor metastasis of osteosarcoma by Raf-1/MEK/ERK/Elk-1/TWIST-1 signaling pathway.
25135600 2015 CCN1 mutation is associated with atrial septal defect.
25104090 2014 Cyr61 promotes growth of pancreatic carcinoma via nuclear exclusion of p27.
25061178 2014 CYR61/CCN1 overexpression in the myeloma microenvironment is associated with superior survival and reduced bone disease.
25059387 2014 Sox4 up-regulates Cyr61 expression in colon cancer cells.
25048722 2014 CYR61 overexpression associated with the development and poor prognosis of ovarian carcinoma.
24973403 2014 CCN1 secretion and cleavage regulate the lung epithelial cell functions after cigarette smoke.
24909560 2015 CCN1 secreted by tonsil-derived mesenchymal stem cells promotes endothelial cell angiogenesis via integrin ?v ?3 and AMPK.
24895995 2014 Role of cysteine-rich 61 protein (CCN1) in macrophage-mediated oncolytic herpes simplex virus clearance.
24780075 2014 Association of BTG2, CYR61, ZFP36, and SCD gene polymorphisms with Graves' disease and ophthalmopathy.
24767859 2014 Matricellular protein CCN1 (CYR61) expression is associated with high-grade ductal carcinoma in situ.
24606730 2014 Cyr61 expression is associated with prognosis in patients with colorectal cancer.
24595148 2014 Cysteine-rich, angiogenic inducer, 61 expression in patients with ovarian epithelial carcinoma.
24517278 2013 Cyr61 is involved in neutrophil infiltration in joints by inducing IL-8 production by fibroblast-like synoviocytes in rheumatoid arthritis.
24485923 2014 Elevated YAP and its downstream targets CCN1 and CCN2 in basal cell carcinoma: impact on keratinocyte proliferation and stromal cell activation.
24449575 2014 A novel p53/microRNA-22/Cyr61 axis in synovial cells regulates inflammation in rheumatoid arthritis.
24430538 2014 The matricellular "cysteine-rich protein 61" is released from activated platelets and increased in the circulation during experimentally induced sepsis.
24317814 2014 MicroRNA-100 inhibits osteosarcoma cell proliferation by targeting Cyr61.
24084383 2013 Myocardin-related transcription factor A is up-regulated by 17?-estradiol and promotes migration of MCF-7 breast cancer cells via transactivation of MYL9 and CYR61.
24037310 2013 The up-regulation of cysteine-rich protein 61 induced by transforming growth factor beta enhances osteosarcoma cell migration.
24009013 2013 Cyr61 is a target for heparin in reducing MV3 melanoma cell adhesion and migration via the integrin VLA-4.
23798676 2013 Degradome products of the matricellular protein CCN1 as modulators of pathological angiogenesis in the retina.
23744557 2013 Interaction of CCN1 with ?v?3 integrin induces P-glycoprotein and confers vinblastine resistance in renal cell carcinoma cells.
23658023 2013 Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance.
23623839 2013 Production of Cyr61 protein is modulated by extracellular acidification and PI3K/Akt signaling in prostate carcinoma PC-3 cells.
23618859 2013 A novel anti-CCN1 monoclonal antibody suppresses Rac-dependent cytoskeletal reorganization and migratory activities in breast cancer cells.
23528710 2013 Caprin-1, a novel Cyr61-interacting protein, promotes osteosarcoma tumor growth and lung metastasis in mice.
23504324 2013 Cysteine-rich protein 61 (CCN1) domain-specific stimulation of matrix metalloproteinase-1 expression through ?V?3 integrin in human skin fibroblasts.
23316072 2013 Role of ?-catenin-regulated CCN matricellular proteins in epithelial repair after inflammatory lung injury.
23259998 2013 Cyr61/CCN1 affects the integrin-mediated migration of prostate cancer cells (PC-3) in vitro.
23196056 2013 Snail promotes Cyr61 secretion to prime collective cell migration and form invasive tumor nests in squamous cell carcinoma.
23141184 2012 [Cyr61 expression influences cancer cell proliferation and apoptosis via PI3K pathway in human ovarian carcinoma cells].
23045290 2013 A functional polymorphism in the CYR61 (IGFBP10) gene is associated with prostate cancer risk.
23027863 2012 The matricellular protein CCN1/Cyr61 is a critical regulator of Sonic Hedgehog in pancreatic carcinogenesis.
22752926 2012 CCN1 promotes tumorigenicity through Rac1/Akt/NF-?B signaling pathway in pancreatic cancer.
22694338 2012 Proteomic analysis of extracellular matrix from the hepatic stellate cell line LX-2 identifies CYR61 and Wnt-5a as novel constituents of fibrotic liver.
22692860 2012 The matrix protein CCN1/CYR61 is required for ?(V)?5-mediated cancer cell migration.
22566095 2012 Cysteine-rich protein 61 (CCN1) mediates replicative senescence-associated aberrant collagen homeostasis in human skin fibroblasts.
22551568 2012 NUR77 inhibits the expression of TIMP2 and increases the migration and invasion of HTR-8/SVneo cells induced by CYR61.
22547695 2012 Cyr61 induces IL-6 production by fibroblast-like synoviocytes promoting Th17 differentiation in rheumatoid arthritis.
22540002 2012 Cyr61/CCN1 is regulated by Wnt/?-catenin signaling and plays an important role in the progression of hepatocellular carcinoma.
22532143 2012 Atrial expression of the CCN1 and CCN2 proteins in chronic heart failure.
22527715 2012 CCN1: a novel inflammation-regulated biphasic immune cell migration modulator.
22401280 2012 Epidermal growth factor upregulates endometrial CYR61 expression via activation of the JAK2/STAT3 pathway.
22363611 2012 TNF?-induced apoptosis enabled by CCN1/CYR61: pathways of reactive oxygen species generation and cytochrome c release.
22253074 2012 Cyr61 increases matrix metalloproteinase-3 expression and cell motility in human oral squamous cell carcinoma cells.
22160564 2012 Cysteine-rich 61 (CYR61) is up-regulated in proliferative diabetic retinopathy.
22056874 2012 Increased vascularity and spontaneous metastasis of breast cancer by hedgehog signaling mediated upregulation of cyr61.
22025384 2012 Cyr61 is regulated by cAMP-dependent protein kinase with serum levels correlating with prostate cancer aggressiveness.
22023263 2012 CYR61 modulates the vascular endothelial growth factor C expression of decidual NK cells via PI3K/AKT pathway.
21995436 2011 Cigarette smoke-induced early growth response-1 regulates the expression of the cysteine-rich 61 in human skin dermal fibroblasts.
21976359 2012 Cyr61 expression in osteosarcoma indicates poor prognosis and promotes intratibial growth and lung metastasis in mice.
21711965 Hypoxia induces cysteine-rich 61, vascular endothelial growth factor, and interleukin-8 expressions in human nasal polyp fibroblasts: An implication of neutrophils in the pathogenesis of nasal polyposis.
21628462 2011 Kallikrein-related peptidase 12 hydrolyzes matricellular proteins of the CCN family and modifies interactions of CCN1 and CCN5 with growth factors.
21618249 2011 Expression and prognostic significance of CEACAM6, ITGB1, and CYR61 in peripheral blood of patients with gastric cancer.
21601497 2011 Expression and significance of Cyr61 in distant metastasis cells of human primary salivary adenoid cystic carcinoma.
21505992 2011 Decreased Cyr61 under hypoxia induces extravillous trophoblasts apoptosis and preeclampsia.
21488975 2011 Retinoids suppress cysteine-rich protein 61 (CCN1), a negative regulator of collagen homeostasis, in skin equivalent cultures and aged human skin in vivo.
21447598 2011 Expression of tumor-promoting Cyr61 is regulated by hTRA2-?1 and acidosis.
21397653 2011 Protective effects of Chlorella-derived peptide on UVB-induced production of MMP-1 and degradation of procollagen genes in human skin fibroblasts.
21393426 2011 CCN1, a candidate target for zoledronic acid treatment in breast cancer.
21349946 2011 Taxol resistance in breast cancer cells is mediated by the hippo pathway component TAZ and its downstream transcriptional targets Cyr61 and CTGF.
21312266 2011 CYR61 downregulation reduces osteosarcoma cell invasion, migration, and metastasis.
21249313 2011 Involvement of Cyr61 in the growth, invasiveness and adhesion of esophageal squamous cell carcinoma cells.
21232118 2011 Cyr61/CCN1 signaling is critical for epithelial-mesenchymal transition and stemness and promotes pancreatic carcinogenesis.
21212405 2011 G(alpha)12/13 induction of CYR61 in association with arteriosclerotic intimal hyperplasia: effect of sphingosine-1-phosphate.
21159247 2010 [Expressions of Cyr61 and WISP-3 in non-small cell lung cancer and its clinical significance].
21153366 2011 The extracellular matrix protein CCN1 dictates TNF? and FasL cytotoxicity in vivo.
21138874 2010 Decreased expression of Cyr61 is associated with prostate cancer recurrence after surgical treatment.
21081514 2011 Expression of CTGF and Cyr61 in colorectal cancer.
20675382 2010 CYR61 regulates BMP-2-dependent osteoblast differentiation through the {alpha}v{beta}3 integrin/integrin-linked kinase/ERK pathway.
20641097 2010 Embryonic expression of the cysteine rich protein 61 (CYR61) gene: A candidate for the development of human epispadias.
20628624 2010 Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".
20531301 2010 Inhibition of AP-1 by SARI negatively regulates transformation progression mediated by CCN1.
20237496 2010 New genetic associations detected in a host response study to hepatitis B vaccine.
20237132 2010 Regulation of the matricellular proteins CYR61 (CCN1) and NOV (CCN3) by hypoxia-inducible factor-1{alpha} and transforming-growth factor-{beta}3 in the human trophoblast.
20233866 2010 Cyr61 mediates hepatocyte growth factor-dependent tumor cell growth, migration, and Akt activation.
20195466 2010 Cyr61/CCN1 displays high-affinity binding to the somatomedin B(1-44) domain of vitronectin.
20097175 2010 CCN1 is critical for acid-induced esophageal epithelial cell transformation.
20056838 2010 Involvement of CYR61 and CTGF in the fascin-mediated proliferation and invasiveness of esophageal squamous cell carcinomas cells.
20043874 2010 Sclerostin binds and regulates the activity of cysteine-rich protein 61.
20010302 2010 Differential expression of CCN1/CYR61, CCN3/NOV, CCN4/WISP1, and CCN5/WISP2 in neurofibromatosis type 1 tumorigenesis.
19950293 2009 A critical role of Cyr61 in interleukin-17-dependent proliferation of fibroblast-like synoviocytes in rheumatoid arthritis.
19632997 2009 Silencing cAMP-response element-binding protein (CREB) identifies CYR61 as a tumor suppressor gene in melanoma.
19584265 2009 Matrix protein CCN1 is critical for prostate carcinoma cell proliferation and TRAIL-induced apoptosis.
19542562 2009 Mechanical regulation of the proangiogenic factor CCN1/CYR61 gene requires the combined activities of MRTF-A and CREB-binding protein histone acetyltransferase.
19364818 2009 Fas-mediated apoptosis is regulated by the extracellular matrix protein CCN1 (CYR61) in vitro and in vivo.
19288017 2009 Prognostic significance of altered expression of SDC2 and CYR61 in esophageal squamous cell carcinoma.
19244129 2009 Alternative splicing of Cyr61 is regulated by hypoxia and significantly changed in breast cancer.
19180570 2009 Cyr61 is up-regulated in prostate cancer and associated with the p53 gene status.
19147534 2009 Sphingosine-1-phosphate regulates glioblastoma cell invasiveness through the urokinase plasminogen activator system and CCN1/Cyr61.
19007976 2009 Cyr61, a member of ccn (connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed) family, predicts survival of patients with endometrial cancer of endometrioid subtype.
18950845 2009 Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study.
18941464 2008 Involvement of Cyr61 in growth, migration, and metastasis of prostate cancer cells.
18936953 2009 Ligand-induced nuclear translocation of S1P(1) receptors mediates Cyr61 and CTGF transcription in endothelial cells.
18819928 2008 A Key role for cyclic AMP-responsive element binding protein in hypoxia-mediated activation of the angiogenesis factor CCN1 (CYR61) in Tumor cells.
18800188 2009 Cysteine-rich 61 (CYR61) inhibits cisplatin-induced apoptosis in ovarian carcinoma cells.
18687805 2008 Thrombin receptor and RhoA mediate cell proliferation through integrins and cysteine-rich protein 61.
18599605 2008 Substance P-mediated expression of the pro-angiogenic factor CCN1 modulates the course of colitis.
18575751 2008 Functional domains of CCN1 (Cyr61) regulate breast cancer progression.
18381294 2008 Involvement of hypoxia-inducing factor-1alpha-dependent plasminogen activator inhibitor-1 up-regulation in Cyr61/CCN1-induced gastric cancer cell invasion.
18212329 2008 Cyr61/CCN1 and CTGF/CCN2 mediate the proangiogenic activity of VHL-mutant renal carcinoma cells.
18202125 2008 Premenstrual regulation of the pro-angiogenic factor CYR61 in human endometrium.
18089610 2007 The circulating proangiogenic factors CYR61 (CCN1) and NOV (CCN3) are significantly decreased in placentae and sera of preeclamptic patients.
18058471 2007 CYR61: a new measure of lung cancer outcome.
18025257 2007 Cysteine-rich 61 (CCN1) enhances chemotactic migration, transendothelial cell migration, and intravasation by concomitantly up-regulating chemokine receptor 1 and 2.
18004727 2008 Dose-dependent differential upregulation of CCN1/Cyr61 and CCN3/NOV by the gap junction protein Connexin43 in glioma cells.
17765657 2008 Bacteria induce CTGF and CYR61 expression in epithelial cells in a lysophosphatidic acid receptor-dependent manner.
17718860 2007 CYR61 polymorphisms are associated with plasma HDL-cholesterol levels in obese individuals.
17699553 2007 Expression of CCN1 (CYR61) in developing, normal, and diseased human kidney.
17673559 2007 A single bout of exercise with high mechanical loading induces the expression of Cyr61/CCN1 and CTGF/CCN2 in human skeletal muscle.
17626014 2007 Vascular endothelial growth factor (VEGF)-induced up-regulation of CCN1 in osteoblasts mediates proangiogenic activities in endothelial cells and promotes fracture healing.
17601910 2007 Endometrial expression of Cyr61: a marker of estrogenic activity in normal and abnormal endometrium.
17579708 2007 Expression of Cyr61, CTGF, and WISP-1 correlates with clinical features of lung cancer.
17437852 2007 Up-regulation of estrogen responsive genes in hypospadias: microarray analysis.
17429007 2007 The angiogenic factor CCN1 promotes adhesion and migration of circulating CD34+ progenitor cells: potential role in angiogenesis and endothelial regeneration.
17234971 2007 Forkhead transcription factor FOXO3a is a negative regulator of angiogenic immediate early gene CYR61, leading to inhibition of vascular smooth muscle cell proliferation and neointimal hyperplasia.
17056474 IGFBP-3 and IGFBP-10 (CYR61) up-regulation during the development of Barrett's oesophagus and associated oesophageal adenocarcinoma: potential biomarkers of disease risk.
16877350 2006 Elevated cysteine-rich 61 mediates aberrant collagen homeostasis in chronologically aged and photoaged human skin.
16804865 2006 Identification of genes modulated in rheumatoid arthritis using complementary DNA microarray analysis of lymphoblastoid B cell lines from disease-discordant monozygotic twins.
16675545 2006 Decreased expression of the angiogenic regulators CYR61 (CCN1) and NOV (CCN3) in human placenta is associated with pre-eclampsia.
16581771 2006 CCN1/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
16243794 2005 Ovarian carcinomas: CCN genes are aberrantly expressed and CCN1 promotes proliferation of these cells.
15961723 2005 Cyr61 protects against hyperoxia-induced cell death via Akt pathway in pulmonary epithelial cells.
15878827 2005 Expression, purification, and functional testing of recombinant CYR61/CCN1.
15782120 2005 Dinucleotide repeats negatively modulate the promoter activity of Cyr61 and is unstable in hepatocellular carcinoma patients.
15592521 2005 A novel CYR61-triggered 'CYR61-alphavbeta3 integrin loop' regulates breast cancer cell survival and chemosensitivity through activation of ERK1/ERK2 MAPK signaling pathway.
15564459 2004 Coxsackievirus B3 infection induces cyr61 activation via JNK to mediate cell death.
15526358 2004 Expressions of cysteine-rich61, connective tissue growth factor and Nov genes in hepatocellular carcinoma and their clinical significance.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15471875 2004 Cyr61 suppresses growth of human endometrial cancer cells.
15389821 2004 Induction and function of CYR61 (CCN1) in prostatic stromal and epithelial cells: CYR61 is required for prostatic cell proliferation.
15077166 2004 Cyr61 suppresses the growth of non-small-cell lung cancer cells via the beta-catenin-c-myc-p53 pathway.
15053922 2004 Three members of the connective tissue growth factor family CCN are differentially regulated by mechanical stress.
15044605 2004 Cyr61, a deregulated gene in endometriosis.
15044484 2004 Cyr61 expression confers resistance to apoptosis in breast cancer MCF-7 cells by a mechanism of NF-kappaB-dependent XIAP up-regulation.
15041728 2004 Levels of expression of CYR61 and CTGF are prognostic for tumor progression and survival of individuals with gliomas.
14988385 2004 Increased expression of CYR61, an extracellular matrix signaling protein, in human benign prostatic hyperplasia and its regulation by lysophosphatidic acid.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12939282 2003 Mechanisms of hypoxic gene regulation of angiogenesis factor Cyr61 in melanoma cells.
12899698 2003 Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways.
12831056 2002 Regulation of angiogenesis and endothelial cell function by connective tissue growth factor (CTGF) and cysteine-rich 61 (CYR61).
12826661 2003 Identification of a novel integrin alpha 6 beta 1 binding site in the angiogenic inducer CCN1 (CYR61).
12736251 2003 Identification of a novel integrin alphaMbeta2 binding site in CCN1 (CYR61), a matricellular protein expressed in healing wounds and atherosclerotic lesions.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12444554 2002 Cyr61 promotes breast tumorigenesis and cancer progression.
12374462 2002 The angiogenic factor Cyr61 is induced by the progestin R5020 and is necessary for mammary adenocarcinoma cell growth.
12364323 2002 Pro-angiogenic activities of CYR61 (CCN1) mediated through integrins alphavbeta3 and alpha6beta1 in human umbilical vein endothelial cells.
12217894 2002 Cyr61 and CTGF are molecular markers of bladder wall remodeling after outlet obstruction.
12036876 2002 Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions.
11810026 Organization and expression of the Cyr61 gene in normal human fibroblasts.
11751417 2001 Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features.
11600415 2001 Regulation of Cyr61 gene expression by mechanical stretch through multiple signaling pathways.
11584015 2001 The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts.
11287419 2001 CYR61 stimulates human skin fibroblast migration through Integrin alpha vbeta 5 and enhances mitogenesis through integrin alpha vbeta 3, independent of its carboxyl-terminal domain.
11120741 2001 The angiogenic factors Cyr61 and connective tissue growth factor induce adhesive signaling in primary human skin fibroblasts.
10852911 2000 Muscarinic acetylcholine receptors induce the expression of the immediate early growth regulatory gene CYR61.
10821835 2000 Adhesion of human skin fibroblasts to Cyr61 is mediated through integrin alpha 6beta 1 and cell surface heparan sulfate proteoglycans.
10446209 1999 Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(IIb)beta(3).
9600969 1998 CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth.
9536281 1997 Chromosomal mapping and expression of the human cyr61 gene in tumour cells from the nervous system.
9528960 1998 The human analog of murine cystein rich protein 61 [correction of 16] is a 1alpha,25-dihydroxyvitamin D3 responsive immediate early gene in human fetal osteoblasts: regulation by cytokines, growth factors, and serum.
9488038 1998 Human CYR61-mediated enhancement of bFGF-induced DNA synthesis in human umbilical vein endothelial cells.
9446626 1998 Adhesion of human umbilical vein endothelial cells to the immediate-early gene product Cyr61 is mediated through integrin alphavbeta3.
9135077 1997 The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p.
8635876 1996 Isolation of genes differentially expressed in human primary myoblasts and embryonal rhabdomyosarcoma.
8125298 1994 Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.