Tbio CYP4F12 Cytochrome P450 4F12

Protein Summary

Description

Catalyzes leukotriene B4 omega-hydroxylation and arachidonic acid omega-hydroxylation but with an activity much lower than that of CYP4F2. Catalyzes the hydroxylation of the antihistamine ebastine. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxdizing arachidonic acid. It can also catalyze the epoxidation of 22:6n-3 and 22:5n-3 polyunsaturated long-chain fatty acids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Uniprot Accession IDs

• Q9HCS2
• E7ET51
• O60389
• Q5JPJ7
• Q9HCS1

Gene Name

• CYP4F12

Ensembl ID

• ENST00000324632
• ENSP00000321821
• ENSG00000186204
• ENST00000517734
• ENSP00000430849
• ENST00000548435
• ENSP00000449703
• ENST00000550308
• ENSP00000448998

Symbol

• CYPIVF12
• F22329_1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.86
biological process	0.77
PubMedID	0.7
pathway	0.68
cellular component	0.67

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Oxygenase / Cytochrome P450 4f12

DTO Classes

Protein / Enzyme / Oxidoreductase / Oxygenase / Cytochrome P450 4f12

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.49   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.49   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0