Tbio | Cytochrome c1, heme protein, mitochondrial |
This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain.
This gene encodes a subunit of the cytochrome bc1 complex, which plays an important role in the mitochondrial respiratory chain by transferring electrons from the Rieske iron-sulfur protein to cytochrome c. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear type 6. [provided by RefSeq, Dec 2013]
This gene encodes a subunit of the cytochrome bc1 complex, which plays an important role in the mitochondrial respiratory chain by transferring electrons from the Rieske iron-sulfur protein to cytochrome c. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear type 6. [provided by RefSeq, Dec 2013]
Comments
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Mitochondrial Complex III Deficiency | 9 | 0.0 | 0.0 |
Disease | Target Count | P-value |
---|---|---|
non-small cell lung cancer | 2890 | 6.5e-16 |
malignant mesothelioma | 3232 | 5.0e-06 |
psoriasis | 6694 | 6.4e-06 |
Multiple myeloma | 1332 | 1.0e-04 |
ovarian cancer | 8520 | 1.4e-04 |
pancreatic ductal adenocarcinoma liver metastasis | 1962 | 8.5e-03 |
lung cancer | 4740 | 1.3e-02 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Contagious pustular dermatitis | 11 | 3.987 | 2.0 |
Barth syndrome | 23 | 3.033 | 1.5 |
Disease | Target Count |
---|---|
Mitochondrial Complex 3 Deficiency, Nuclear Type 6 | 1 |
Disease | log2 FC | p |
---|---|---|
lung cancer | 1.200 | 1.3e-02 |
malignant mesothelioma | 1.100 | 5.0e-06 |
Multiple myeloma | 1.619 | 1.0e-04 |
non-small cell lung cancer | 1.112 | 6.5e-16 |
ovarian cancer | 2.100 | 1.4e-04 |
pancreatic ductal adenocarcinoma liver m... | -1.275 | 8.5e-03 |
psoriasis | 2.600 | 6.4e-06 |
Species | Source | Disease |
---|---|---|
Inparanoid OMA | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG |
MAAAAASLRGVVLGPRGAGLPGARARGLLCSARPGQLPLRTPQAVALSSKSGLSRGRKVMLSALGMLAAG 1 - 70 GAGLAMALHSAVSASDLELHPPSYPWSHRGLLSSLDHTSIRRGFQVYKQVCASCHSMDFVAYRHLVGVCY 71 - 140 TEDEAKELAAEVEVQDGPNEDGEMFMRPGKLFDYFPKPYPNSEAARAANNGALPPDLSYIVRARHGGEDY 141 - 210 VFSLLTGYCEPPTGVSLREGLYFNPYFPGQAIAMAPPIYTDVLEFDDGTPATMSQIAKDVCTFLRWASEP 211 - 280 EHDHRKRMGLKMLMMMALLVPLVYTIKRHKWSVLKSRKLAYRPPK 281 - 325 //