Property Summary

NCBI Gene PubMed Count 1,166
PubMed Score 2485.68
PubTator Score 3388.38

Knowledge Summary

Patent (288,649)

TINX Plot

  Disease (6)

Disease Target Count
WHIM syndrome 1

Expression

  Differential Expression (38)

Disease log2 FC p
nephrosclerosis 1.945 2.1e-03
Waldenstrons macroglobulinemia 1.484 2.9e-02
malignant mesothelioma 3.800 2.4e-07
posterior fossa group B ependymoma 2.400 6.3e-08
esophageal adenocarcinoma 2.400 2.2e-02
psoriasis -2.500 7.0e-09
cutaneous lupus erythematosus 3.000 4.5e-03
astrocytoma 3.500 5.8e-03
glioblastoma 4.100 1.7e-03
oligodendroglioma 1.600 2.6e-08
osteosarcoma -2.886 2.0e-04
sonic hedgehog group medulloblastoma 3.700 2.4e-07
periodontitis 1.900 2.3e-31
atypical teratoid / rhabdoid tumor 3.800 1.4e-06
medulloblastoma, large-cell 2.100 7.9e-04
primitive neuroectodermal tumor 3.700 7.7e-05
juvenile dermatomyositis 1.310 1.5e-07
Atopic dermatitis 1.700 7.0e-03
tuberculosis -1.400 1.0e-05
primary pancreatic ductal adenocarcinoma 1.681 2.7e-02
lung cancer -1.500 6.8e-05
pancreatic cancer 1.700 1.3e-02
interstitial cystitis 1.800 4.8e-02
cystic fibrosis 1.400 1.5e-03
adult high grade glioma 2.400 1.3e-03
pilocytic astrocytoma 2.400 2.5e-06
primary Sjogren syndrome 2.600 2.9e-04
invasive ductal carcinoma 3.000 2.0e-03
lung carcinoma -1.800 7.4e-11
breast carcinoma 1.400 6.9e-17
gastric carcinoma 1.900 4.4e-02
ductal carcinoma in situ 2.700 7.4e-04
ulcerative colitis 4.400 1.0e-06
ovarian cancer 4.800 1.4e-08
Breast cancer 1.200 8.5e-03
pituitary cancer -2.700 1.8e-06
Down syndrome 1.500 3.7e-02
dermatomyositis 2.100 5.4e-04

Protein-protein Interaction (3)

MLP Assay (1)

AID Type Active / Inconclusive / Inactive Description
651902 confirmatory 0 / 0 / 9 SAR analysis of small molecule antagonists of the CXCR6 receptor using a CXCR4 receptor luminescent beta-arrestin counterscreen

Gene RIF (1583)

PMID Text
27041792 Study shows that serum concentrations of CXCL12 were significantly higher, while those of its receptor CXCR4 were significantly lower in esophageal cancer (EC) patients suggesting that suggest that serum CXCR4 and CXCl12 may improve the diagnosis of EC patients.
27005825 Our results suggest that genetic variants at the CXCR4 locus may predispose to the development of juvenile idiopathic arthritis.
26978017 The simultaneous determination of the chemokine receptor CXCR4 and proliferative activity (Ki-67 expression) can define disease prognosis in view of relapse-survival rates in patients with Stage II colon cancer after radical surgical treatment
26967480 Human papillomavirus induced skin neoplasm targeting CXCR4 chemokine receptor, shows symptomatic improvement in mice models.
26896000 Study suggests that CXCR4-SDF-1 axis is involved in mobilization and trafficking of epithelial circulating tumor cells in primary breast cancer.
26851944 Data suggest targeting the stromal cell-derived factor-1 (SDF-1)/chemokine receptor 4 (CXCR4) axis might provide a therapeutic strategy for endometrial cancer (EC) treatment.
26829983 Triggering of LLT1 supported B cell activation, CD83 upregulation, and CXCR4 downregulation
26826409 CXCR4 was an independent factor in predicting unfavorable overall survival myasthenia gravis-associated thymoma.
26782435 This indicated that elevated CXCR4 expression may be correlated with aggressive metastasis, advanced TNM stages, and shorter OS rate in NSCLC patients, suggesting a poor prognostic outcome of this disease
26782415 these results indicate that the chemokine receptor CXCR4 and its ligand CXCL12 play important roles in the occurrence and development of bladder cancer.
26780310 Dimers CXCR4 and CXCR7 are involved in TFF3-dependent activation of cell migration, but not cell proliferation. The ERK1/2 pathway is activated in the process, but not influenced by CXCR4 or CXCR7.
26748383 A balanced regulation of G-protein dependent and independent pathways is required for controlling CXCR4 receptor mobility, and potentially subsequent controlled signal transduction.
26744352 We used IT1t, a potent CXCR4 antagonist, and show for the first time its promising anti-tumor effects. In conclusion, we confirm the validity of the zebrafish as a xenotransplantation model and propose a pharmacological approach to target CXCR4 in TNBC
26722521 Expression levels of CXCR4 and CXCR7 in breast cancer tissues were significantly higher than that in adjacent normal tissues and patients with high CXCR4 and CXCR7 expression had a shorter survival time compared with those with low expression.
26721717 that the roles of CXCR4, CXCR7, and CXCL12 are associated with trophoblastic cells apoptosis and may be linked to the occurrence and development of severe preeclampsia
26667813 Upregulated myocardial CXCR4-expression after myocardial infarction assessed by simultaneous GA-68 pentixafor PET/MRI
26659815 The presence of multiple CXCR4(WHIM) mutations within individual Waldenstrom Macroglobulinemia patients may be indicative of targeted CXCR4 genomic instability
26602164 Blood fibrocytes are recruited during COPD exacerbations and related to mortality and low lung function. The CXCL12/CXCR4 axis is involved in such fibrocyte recruitment.
26599430 report a direct interaction between SOD1 and CXCR4. We showed that SOD1 interacts directly with the first intracellular loop (ICL1) of CXCR4 and that the CXCL12/CXCR4-mediated regulation of AKT activation, apoptosis and cell migration in prostate cancer (PCa) cells is differentially modulated under normal versus hypoxic conditions when SOD1 is present
26576337 the results from present study indicated that rs2228014 genetic variant does not alter CXCR4 mRNA or protein expression.
26560447 interstitial fluid flow promoted invasion of hepatocellular carcinoma derived cell lines via the C-X-C chemokine receptor type 4 (CXCR4)/C-X-C motif chemokine 12 (CXCL12) signaling axis.
26552750 Consistent with the loss of CXCR4 and gain in CD26, migratory responses to exogenous CXCL12 were eliminated in cells pretreated with cytotoxic agents, although cells retained basal motility
26551719 Data shows the relative expression of CXCR4 and CXCR7 in platelets, their dynamic trafficking, how they differentially mediate the functional and survival response to some chemokines, and their prognostic value in coronary artery disease. [review]
26538086 Its remarkable effect on inhibiting CXCR4/CXCL12-mediated adhesion and migration of AML cells.
26452480 The increased susceptibility of T cells from the elderly to HIV-1 infection correlated directly with CXCR4 and inversely with CD4 expression.
26439684 Knockdown of HIF2alpha abrogated CXCR4 expression.
26428435 Data indicate that CXC chemokine CXCL14, CXC chemokine receptor CXCR7 and the ratio between CXC chemokine receptor CXCR4-2 and CXCR4-1 could predict diseae free survival in Ewing sarcoma patients.
26414794 CXCL12/CXCR4 activation by cancer-associated fibroblasts mediated integrin beta1 clustering at the cell surface and promoted the invasive ability of gastric cancer cells
26413813 Evidences suggest an indispensable role of GLI1 in the migration and metastasis of breast cancer cells through CXCL12/CXCR4 signaling enhancement.
26406413 mRNA expression of CXCR4 was significantly elevated in colorectal cancer.
26404566 EZH2/miR-622 promotes hepatoma tumorigenesis through CXCR4 activation.
26398122 This study demonstrates that the effects of CXCR4 inhibition on blast suppression and immune cell function in the tumor microenvironment and chemotherapy with plerixafor represents an advanced therapeutic strategy of targeting the leukemic niche.
26396176 CXCR4 signaling has a role in radiation-induced lung damage that promotes breast cancer lung-metastasis
26385890 Diffuse-type gastric cancer cells might switch their driver pathways from FGFR2 signaling to SDF1/CXCR4 axis through HIF1 in hypoxic tumor microenvironments.
26374452 CXCL12 was expressed in 43.3 % and CXCR4 in 66.1 % of the samples and both were correlated with HPV/p16(INK4A) positivity.
26350264 CXCR4/SDF-1 signaling involves autophagy induction to promote malignant cell survival in any cancer.
26346005 Report over expression of CXCR4 in human abdominal aortic aneurysm tissue.
26338423 These results suggest that targeting the production of CXCR4 and blocking the CXCL12-CXCR4 pathway might be effective strategies for treating NSCLCs harboring a specific type of EGFR mutation.
26321665 Two novel CXCR4 splice variants were discovered using whole transcriptome sequencing.
26318034 chemokine receptor CXCR4 is targeted by peptide Nef-M1, which inhibits tumor angiogenesis and epithelialtomesenchymal transition in colon and breast cancers
26282174 Recycling accounts, to a major extent, for the high levels of surface CXCR4/CCR7 on CLL cells. Increased CCR4/CCR7 is detectable not only in circulating leukemic cells, but also in secondary lymphoid organs of CLL patients with lymphoadenopathy.
26279442 MMP26+CXCR4+ cells may be circulating tumor cells in hepatocellular carcinoma.
26277915 CXCR4 was expressed mainly in tumor cells. The recurrence pattern was significantly related to this. However, CXCR4 was not an independent prognostic factor for progression-free survival or overall survival.
26269605 Data suggest that sequenced administration of CXCR4 receptor antagonists with cytotoxic chemotherapy synergize to reduce distant metastases.
26269531 pharmacologic blockade of CXCR4 selectively reduced M2-related TAMs after chemotherapy, especially those in direct contact with blood vessels, thereby reducing tumor revascularization and regrowth
26261552 CXCR4 inhibitor attenuates allergen-induced lung inflammation by down-regulating MMP-9 and ERK1/2 expression.
26259237 there is an elevation in CXCR4 and a decrease in SSTR2A expression with increasing malignancy in gastroenteropancreatic neuroendocrine neoplasms
26235278 Data show that notch pathway is activated in ovarian cancer specimens and correlates with chemokine receptor CXCR4/chemokine CXCL12 (SDF1alpha) expression and high proliferation levels.
26216880 Dual targeting of the chemokine receptors CXCR4 and ACKR3 with novel engineered chemokines.
26212126 Data show that interferon-beta1b pretreatment decreases chemokine (C-X-C motif) receptor 4 (CXCR4) expression in vitro.
26207425 identified among the key genes in circulating monocytes that were altered by exercise
26205821 Data show that transcription factors PAX3 and FOXD3-mediated melanoma cell migration is dependent on promoting the expression of chemokine receptor CXCR4.
26203228 Aberrant CXCR4 expression plays an important role in the carcinogenesis and metastasis of hepatocellular carcinoma.
26195666 IQGAP1 critically mediates CXCR4 cell surface expression and signaling.
26178998 HIV-1 Nef, a key factor for viral pathogenesis, downregulates functionally important molecules from the surface of infected cells, including the viral entry receptor CD4 and coreceptors CCR5 and CXCR4.
26176534 IL-1beta and IL-1R1 promote cancer growth and metastasis by up-regulating CXCR4 expression and that CXCR4 may be a link between inflammation and cancer.
26166636 The modulation of natural killer cells and maternal-fetal immune tolerance is regulated through the CXCL12/CXCR4 pathway.
26155911 In acute myeloid leukemia patients, high CXCR4 expression independently increased the probability of relapse.
26154069 This study suggests that CXCR4 may be an effective target for nanocarrier-based therapies.
26150700 Review/Meta-analysis: CXCR4 protein expression is associated with an increased risk and worse survival in NSCLC patients.
26141860 microenvironment stimuli eliciting epithelial-to-mesenchymal transition are able to increase the dissemination potential of lung cancer cells through the generation of the CD133(+)/CXCR4(+)/EpCAM(-) subset.
26130416 Increasing evidence from previous studies suggested that C-X-C motif chemokine 12 (CXCL12)and its receptor CXCR4 may provide novel diagnostic and prognostic strategies to reduce the burden of Esophageal cancer
26092504 Esophageal squamous cell carcinoma cells coexpressing CD133 and CXCR4 possess the characteristics of cancer stem cells.
26091099 The pooled hazard ratio of the seven studies that reported on patients overall survival revealed a correlation between expression of CXCR4 and poor prognosis.[meta-analysis]
26085643 Knock-out of CXCR4 in radial glia caused disrupted radial glia scaffold in developing spinal cord.
26083776 CXCR4 is downregulated in metastasized breast cancer cells and implicated in their dormancy
26083631 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
26082201 micrornas directly target the 3'untranslated region of both uPAR- and CXCR4-mRNAs.
26080355 2 allosteric binding sites: 1 in the intracellular loops 1, 2 and 3 (for ATI-2341), and another at a subsite of the main extracellular orthosteric binding pocket between extracellular loops 1 and 2 and the N-terminus (for AMD11070 and GSK812397).
26073897 report provides novel information on the potential activity of CXCR4 inhibitors on the formation and progression of Pca bone and soft tissue metastases
26058076 Authors demonstrate that the chemokine receptor CXCR4 is essential to the LIC activity of T-ALL leukemic cells both in NOTCH-induced mouse T-ALL and human T-ALL xenograft models.
26055363 The presence of a Vif-defective virus correlated with CXCR4 usage.
26045751 Endometrial stromal cells spatiotemporally co-express CXCR4 and CXCR7 and it is regulated by estrogen and progesterone.
26045293 results demonstrate that hypoxia-mediated regulation of microRNA-146a, which controls CXCR4 expression in monocytic cells, is lost in acute monocytic leukemia
26044561 we implanted an Alzet osmotic pump with the stents to gradually release AMD3100, a specific inhibitor binding of SDF-1 and its receptor C-X-C chemokine receptor 4 (CXCR4), at the site of stents in mice that had developed pancreatic cancer.
26037167 The expression of the chemokine receptors CXCR3, CXCR4 and CXCR7 and their ligands.
26026718 The expression of CXCR4 and beta-catenin mRNA and protein was significantly higher in OS tissues.
26023083 HER2 inhibition can enhance or restore ER expression with parallel Bcl2 upregulation, representing an ER-dependent survival mechanism potentially leading to anti-HER2 resistance.
26020117 in human ovarian cancer cells CXCR4 and CD133 expression identified a discrete population with stem cell properties that regulated tumor development and chemo resistance
25997540 the CXCL12-CXCR4 axis regulated OS survival and metastasis through the JNK and Akt pathways, and blocking them with AMD3100 was found to be a potential OS treatment.
25995033 Synovial SDF-1 correlated with disease activity, and its receptor CXCR4 was related to joint destruction in rheumatoid arthritis patients treated with golimumab.
25987090 CXCR4 overexpression is associated with Colorectal Cancer.
25985398 Cell-to-cell transmission was mediated by a unique mechanism by which immature viral particles initiated a fusion process in a CXCR4-dependent, CD4-independent manner.
25985398 HIV-1 (NL4-3 derived NLENG1 (enhanced green fluorescent protein, (EGFP) gene linked with internal ribosome entry site between env and nef genes)) cell-to-cell transmission from lymphocytes to astrocytes requires CXCR4
25976655 after estradiol (E2) treatment a marked increase in CXCL12 secretion and CXCR4 expression in secretory phase ESCs was observed together with decreases in autophagy grade, punctuate LC3B immunofluorescent staining and autophagy-associated protein levels
25966814 CXCR4/CXCL12 Signaling in Immature Hematopoiesis--Lessons From Pharmacological and Genetic Models.
25960214 This study indicated that one key to the role of the CXCR4/CXCL12 axis is activation of the Wnt/beta-catenin pathway.
25957946 The estradiol-CXCL12/CXCR4 signaling pathway may be useful in determining treatments for endometrial disorders, and may be antagonized to block stem cell migration to endometriosis.
25955316 CXCR4 and CXCR7 receptors play a role in organ selective homing and invasion. The balance in the expression levels of the two CXCL12 receptors reveals their participation into complex mechanisms controlling metastatic homing
25955111 miR-494 suppresses the progression of breast cancer through the Wnt/beta-catenin signaling pathway, which is mediated by CXCR4.
25916504 Measured is the Young's modulus, the CXCR4 surface density, and CXCR4 unbinding force on live metastatic breast cancer cells by atomic force microscopy.
25899003 We reproducibly associate higher expression of the ligand-receptor axis of TFF2 and CXCR4 with BRAF V600E-mutant colon cancer
25895986 Hormonal contraceptive use in at-risk, HIV-uninfected women was associated with greater surface expression of CD4, CCR5, or CXCR4.
25884570 CXCL12-mediated cell motility was CXCR7-dependent, with CXCR7 expression required for optimal expression of CXCR4 protein
25882196 kinetic and affinity data are consistent with previously published radioligand-binding experiments using cells and label-free experiments with solubilized CXCR4.
25880110 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
25872129 Review of the role of chemokine receptors CXCR4/CXCR7 and their primary heterodimeric ligands CXCL12 and CXCL12/high mobility group box 1 in pancreatic cancer growth and development.
25866764 Construction of a CXCL12-KDEL fusion gene to inhibit head and neck squamous cell carcinoma metastasis by intracellular sequestration of CXCR4.
25866254 SEMA3F functions as a suppressor of colorectal cancer metastasis by down-regulating the ASCL2-CXCR4 signaling axis.
25860928 Recurrence of glioblastoma after chemoraditherapy could be associated with a switch of angiogenic pattern from VEGFR2-HIF1alpha to CXCL12-CXCR4 pathway.
25846512 Platelet activation with a PAR1 agonist triggered TGF-beta secretion, which induced EMT of via the downregulation of miR-200b expression, and activated platelets had a chemotactic effect on colon cancer cells mediated by the upregulation of CXCR4
25843954 HIF-1alpha and reactive oxygen species mediate radiation-induced invasiveness through the SDF-1alpha/CXCR4 pathway in non-small cell lung carcinoma cells.
25834393 meta-analysis suggest that CXCR4 expression is associated with an increased risk and worse survival in non-small cell lung cancer patients; the aberrant CXCR4 expression plays an important role in the carcinogenesis and metastasis of NSCLC
25819228 the detection of MYD88 L265P mutation in FFPE samples is reliable and useful for subtyping small B-cell lymphomas in BM biopsies. In addition, the presence of CXCR4 mutations identifies a subgroup of LPL patients with higher disease activity.
25815440 The well-known antioxidant Res effectively blocked these effects and reduced phosphorylation of nuclear factor (NF)-kappaB, an upstream activator of CXCR4. Furthermore, Res also suppressed VEGF secretion induced by SDF-1, a ligand of CXCR4
25809793 SDF-1alpha is involved in homing of CXCR4+ GSLCs and leukocytes and that cathepsin K and osteopontin are involved in the migration of GSLCs out of the niches
25808184 hepatocellular carcinoma cells stably expressing MMP10 had increased CXCR4 expression and migratory capacity
25807049 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
25801155 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
25785610 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
25775528 heteromeric receptor complexes between alpha1A-AR and CXCR4 and between alpha1B-AR and CXCR4 are constitutively expressed in rat and human vascular smooth muscle cells; the quaternary structure of the receptor complex is important for signaling and contraction
25735334 CXCR4 and CD133 co-expression was associated with lymphatic metastasis in stage II~III colon cancer.
25712213 Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors.
25705792 Authors found that PLZF mediates suppression of miR-146a to control increases of CXCR4 and TRAF6 protein levels in human primary CD4(+) T lymphocytes.
25704914 The mechanisms that regulate the intracellular trafficking of CXCR4 in hepatocellular carcinoma cells, were examined.
25704881 Gene expression profiling suggested that alterations in the tumor microenvironment, increased tumor proliferation, and the dissemination of CXCR4+ tumor cells to distant organs were underlying molecular mechanisms responsible for the poor prognosis.
25688986 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
25681335 Data show that in addition to the inhibition of transforming growth factor beta 1 (TGF-beta1) and interleukin 10 (IL-10), bortezomib inhibits mRNA and protein expression of the chemokine receptor CXCR4 in cutaneous T cell lymphoma cells.
25679210 Coexpression of EGFR and CXCR4 predicts poor prognosis in resected pancreatic ductal adenocarcinoma
25676691 VEGFR inhibitors upregulate CXCR4 in VEGF receptor-expressing glioblastoma in a TGFbetaR signaling-dependent manner.
25672610 these data suggest that CD90+CXCR4+ HCC cells may be CTSCs and selective elimination of these cells may substantially improve the current hepatocellular carcinoma therapy by reducing cancer metastasis.
25671300 CXCR4 overexpression significantly correlates with negative patient outcome in bronchopulmonary neuroendocrine neoplasms.
25660395 findings highlight a potential prognostic value of platelet expression CXCR4 on clinical outcomes in patients with CAD
25636314 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
25625471 Glycoprotein G attaches to cell surface glycosaminoglycans and induces lipid raft clustering, increasing the incorporation of CXCR4 receptors into these microdomains.
25620445 we investigated the changes in promoter methylation patterns using methylation arrays and observed that the promoters of immunomodulatory factors, COX2 and PTGES, and migration-related factors, CXCR2 and CXCR4, were hypomethylated after 5-aza treatment
25619477 Fraxiparine could significantly inhibit CXCL12-mediated chemotactic migration of A549 and 95D cells in a concentration-dependent manner.
25613038 Our findings have important potential implications demonstrating that together with clinical prognostic factors such as radiotherapy and age, CXCR4 and IGF-1R negatively influences survival in patients with localized SS.
25612609 this study reports the crystal structure of the chemokine receptor CXCR4 in complex with the viral chemokine antagonist vMIP-II at 3.1 angstrom resolution.
25605718 Receptor CXCR4 signaling promotes lysosomal and ESCRT-dependent degradation of DEPTOR, an antagonist of mTORC2, that regulates Akt activation and signaling.
25605248 High CXCR4 expression is associated with perineural invasion in pancreatic cancer.
25595802 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
25557636 The CXCR4 and CXCL12 are extensively expressed in primary rectal tumors of patients presenting with metastatic disease, while radiochemotherapy and bevacizumab further upregulate CXCL12 expression.
25549045 This study demonstrated a potentially reno-protective role for CXCR4 in diabetes that is impeded in its actions in the human kidney by the coincident up-regulation of ligand-inactivating endopeptidases.
25544759 Data indicate that (C-X-C motif) receptor 4 (CXCR4) can modulate cisplatin sensitivity in triple-negative breast cancer (TNBC) cells and suggests that chemokine CXCR4 may be a therapeutic target for TNBC.
25527973 The role of NF-kappaB signaling pathway in the regulation of CXC chemokine receptor-4 (CXCR4) in neuroblastoma metastasis, was investigated.
25526031 Results identify macrophages as important players in MM tumorogenicity, and recognize the CXCR4/CXCL12 axis as a critical regulator of MM-stroma interactions and microenvironment formation.
25504440 Data suggest that the intrinsic transforming growth factor beta 2-triggered stromal cell-derived factor-1-C-X-C chemokine receptor-4 signaling is crucial for drug resistance in bone marrow (BM)-slow-cycling disseminated tumor cells (DTCs).
25504108 data demonstrate that CXCR4 is a candidate gene involved in the development of metastastic lesions in specific organs, such as the lungs, bone and liver, which can secrete high concentrations of SDF-1, the sole ligand of CXCR4.
25503960 These findings indicate that effective inhibition of neuroblastoma metastasis should be directed against the inflammatory cytokine-induced NFkappaB/CXCR4/SDF1alpha signaling pathway.
25495598 The mean fluorescence intensity of CXCR4-expressing cells was significantly higher in HIV-infected normal progressors in both memory and naive CD4(+) cells, but not in CD8(+) cells.
25482641 Regulated transgene expression study of CXCR4 constitutive active mutants revealed their significantly enhanced cell adhesion efficiency to endothelium and extracellular matrix protein.
25474514 We assessed the relative expressions of CXCL12, CXCR4 and CXCR7 in the stroma and the tumour of head and neck squamous cell carcinoma
25471741 CXCL12/CXCR4 signaling promotes cholangiocarcinoma progression and metastasis via canonical Wnt pathway.
25464914 This study found that elevated mRNA levels for CXCR7 (+29%; p<.0001) and CXCR4 (+14%, p=.052) in schizophrenia subjects.
25451233 essential CXCL12-operated functions of CXCR4 are insensitive to CXCL14
25450979 CD138 myeloma cell-directed cross-talk with BMSCs (bone marrow stromal cells) and reveal that CD138 myeloma cells regulate multiple myeloma-BMSC stiffness through SDF-1/CXCR4/AKT signaling.
25421212 SDF-1 up-regulates survivin via MEK/ERK and PI3K/AKT pathway, leading to cell cycle progression
25400739 SNCG, MAP2, SDF-1 and CXCR4 may play an important role in the carcinogenesis, progression, invasion and metastasis of gastric adenocarcinoma.
25387392 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
25378977 Suggest tissue expression of NF-kappaB/CXCR4 may not be an independent prognostic marker in diffuse large B-cell lymphoma patients treated with R-CHOP.
25376609 Data identify CXCR4 as a transcriptional target of DeltaNP63alpha and indicate that DeltaNP63alpha enhances CXCR4 expression in breast cancer cells via its binding at two regions within the CXCR4 promoter.
25371371 Direct inhibition of MYD88(L265P) signalling overcomes CXCL12 triggered survival effects in CXCR4(WHIM) -mutated cells supporting a primary role for this survival pathway in WM.
25368239 High nuclear CXCR4 expression is associated with gastric cancer.
25367885 In U87 glioma cells, C23 plays a crucial role in activation of SDF-1-induced ERK and PI3K/AKT pathways via interacting with CXCR4. C23 interacted with CXCR4 once U87 was exposed to SDF-1 treatment.
25363530 CXCR4 affects the prognosis of HCC patients but CXCR7 does not.
25359780 CXCL12/CXCR4 signaling has a role in docetaxel-induced microtubule stabilization via p21-activated kinase 4-dependent activation of LIMK1
25356048 Genetically modified mesenchymal stem cells expressing CXCR4 showed greater colonization and conferred better functional recovery in damaged liver.
25355818 this study proposes that FLNA interaction with ICL3(intracellular loop) is central for endocytosis and signaling of WT and WHIM-like CXCR4 receptors.
25349153 CXCR4 and CD49d are important modulators of prognosis in chronic lymphocytic leukemia patients.
25344664 We review the function of SDF-1 and CXCR4 in the control of this process referring to our previous work in shoulder muscle and cloacal/perineal muscle development.
25326893 CXCR4 siRNA prohibited SDF-1-induced AKT and ERK phosphorylation, at the same time, EMT biomarker changes were not observed. The SDF-1/CXCR4 axis triggers EMT, tumor cell invasion and proliferation via activation of PI3K/AKT and ERK pathways.
25326811 nucleolin may interact with more G protein-coupled receptors, at least chemokine receptor. Our study will lay a new foundation for cancer therapy by antagonizing nucleolin and CXCR4.
25322170 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
25321183 HIV-CRCX4 defined by population sequencing (PS) had good agreement with lower stringency DS and was significantly associated with lower odds of breast cancer
25313689 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
25312253 We show that E5 has high affinity to multiple AML cells with high CXCR4 level in a concentration dependent manner. E5 significantly inhibits CXCL12- or murine stromal cell (MS-5)-induced migration of leukemia cells
25310198 Targeting the CXCL12-CXCR4/JAK2/STAT3 signaling pathway may be a potential therapeutic strategy for the treatment of breast cancer.
25305322 Synaptic release of CCL5 storage vesicles triggers CXCR4 surface expression promoting CTL migration in response to CXCL12.
25301050 The degree of expression of CXCR-4 and COX-2 is related to invasiveness in both basal cell carcinomas and well-differentiated squamous cell carcinomas of the skin.
25283845 upregulated in choriodecidua following labor
25283599 Rises in cAMP were significantly blunted by SDF-1alpha, which could also enhance collagen-mediated Ca2+ mobilisation, both of which were mediated by CXCR4.
25275127 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
25265194 differences in the genetic diversities between X4 and R5 were readily identified within these co-linear sequences in HIV-1-infected patients
25265194 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
25249257 High CXCR4 expression is associated with metastasis of renal cell carcinoma.
25232565 CXCR4 has been demonstrated to be strongly related to tumour progression in advanced colorectal cancer.
25231990 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
25231113 CXCR4 expression enhances diffuse large B cell lymphoma dissemination and decreases patient survival.
25230750 CXCR4-B, but not CXCR4-A, mediates an efficient HIV-1 X4 entry and productive infection.
25213993 CXCR4 expression in gliomas can be recommended as evidence of WHO grade and indeed predict 3-year overall survival.
25211166 Higher CXCR4 mRNA in melanoma patients with a BRAF mutation suggests its utility as a putative therapeutic target.
25205627 CXCR4 chemokine is upregulated in a dose- and time-dependent manner in the presence of metallic wear debris.
25204042 Data indicate there is a pool of CD34/CXCR4+ stem cells circulating in large number in peripheral blood of acute myocardial infarction patients post infarction together with low CXCR4 expression on these cells.
25193961 High CXCR4 expression is associated with acute myeloid leukemia.
25193376 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
25150783 SDF-1/CXCR4 axis activation-induced colorectal cancer invasion and EMT was effectively inhibited by the Wnt signaling pathway inhibitor Dickkopf-1.
25150002 an increase in the IL-6 levels, CXCR4 and CCR-5 receptors was observed in both women and men with all types of depression
25145299 CXCR4 promotes GSK3beta expression via the Akt cell signaling pathway in pancreatic cancer cells.
25120753 these data suggest that uPAR and CXCR4 co-expression predicts worse prognosis of small cell lung cancer patients
25118295 CXCR4 is associated with perineural invasion in adenoid cystic carcinoma. AMD3100 inhibits CXCR4 to effectively diminish perineural invasion of ACC.
25114911 Studied downregulation of CXCR4 in cervical cancer cell lines and primary tumors; results show epigenetic silencing of CXCR4 makes the cells inefficient to respond to the paracrine source of SDF-1alpha leading to loss of cell adhesion.
25103869 CXCR4 is strongly expressed in vessels close to fibrotic areas in biopsy specimens from patients with idiopathic pulmonary fibrosis, by comparison with control lungs.
25089012 Galphas plays a role in both CXCR4 signaling and trafficking pathways.
25086956 High VEGF expression also was the independent adverse prognostic factor for embryonal rhabdomyosarcoma (ERMS). Because CXCR4, CXCR7, and VEGF are widely expressed in rhabdomyosarcoma (RMS).
25085362 Results show that CXCL12/CXCR4 receptor and ligand are respectively expressed by different GBM cell populations and by the subventricular zone. Results suggest role of the CXCL12/CXCR4 signaling in an original model of brain cancer invasion.
25074471 The CXCL12/CXCR4 pathway contributes in both mice and patients to the enhanced recruitment of CD4+ T-cells in non-alcoholic steatohepatitis.
25072615 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
25042571 Gene microarray analyses identified CXCL12 as a major oestrogen-driven target gene in carcinoma-associated fibroblasts (CAFs), and CAFs recruit mast cells via CXCL12 in a CXCR4-dependent manner.
25041836 the differential expression of CXCR4 in intratumoral stroma and SDF1 in adjacent normal mammary cells may predict clinical outcome in breast cancer patients
25032817 Coreceptor switch from CCR5 to CXCR4 is associated with HIV disease progression.
25031337 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
25030358 miR-302a inhibited the invasion and metastasis of breast cancer cells in vitro and in vivo and reduced the expression of CXCR4.
24999477 According to the analysis of docking poses, hydrophobic interactions, hydrogen bond variations, and the comparison of the effect on CXCR4 and CCR5, these results indicate Saussureamine C may have better effect on these two receptors
24998559 High CXCR4 expression is associated with perineural invasion in pancreatic cancer.
24992171 The absence of CXCR4 expression and BRAF mutation in cancers with a minor PD component underlined different pathogenic and metastatic processes in comparison with WDCs.
24991762 CXCR4-CXCL12-CXCR7 regulates mTOR signaling in renal cancer cells.
24990163 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
24982366 The CXCL12-CXCR4 axis may influence the expression of VEGFR3 in urothelial bladder carcinoma and promote tumor recurrence.
24973450 The critical bone marrow-derived signals essential for CD8+ T cell homeostatic self-renewal appear to be dispensable to yield self-renewing, functionally asymmetric cell fates during rechallenge.
24970694 Overexpression HIF1alpha was related with higher expressions of CXCR7 and CXCR4, otherwise IDH1 mutation related with lower expression of both genes in astrocytomas.
24947029 Thus acute exercise increases CXCR4 expression.
24934367 High levels of CXCL12 and CXCR4 expression were significantly associated with a poor recurrence-free survival and were the prognostic factors for ACP recurrence in pediatric patients.
24925969 SDF-1alpha stimulates the CXCR4/PI3K/Rac1 signaling pathway and actin cytoskeleton rearrangement to suppress endothelial permeability.
24913264 This review presents evidence showing that CXCR4/CXCL12 signaling contributes to neural progenitor cells migration to areas of central nervous system damage. [review]
24912431 MN1 prevents activation of the immune response pathway, and suggest restoration of IRF8 signaling as therapeutic target in AML
24906407 our mechanistic in vitro assays and in vivo results suggest that a reduction in chemokine CXCL12 expression, with an enhancement of CXCR4 expression, provoked by COUP-TFI, could be associated with an increase in the invasive potential of breast cancer
24885150 Translocation kinetics and modelling indicates CXCR4 endocytosis rate regulates surface expression of CXCR4.
24870556 The potential functions of FOXP3 in breast epithelium can now be extended to include regulation of CXCR4 expression and response to the pro-metastatic chemokine CXCL12.
24859274 Decrease in CXCR4 expression in the bone marrow of NHL patients after chemotherapy may be a good prognostic factor.
24855209 The rearrangement between MAML2 and CXCR4, created by a t(2;11)(q22.1;q21) translocation, results in a new fusion gene in which a portion of CXCR4 is linked to the MAML2 gene.
24816217 CXCR4 blockade induces atherosclerosis by affecting neutrophil function.
24810923 Immunohistochemical analysis showed the co-expression of CXCR4 and CXCL12 correlated with lymph node metastasis and TNM stage
24799056 This review focuses on how CXCL12-CXCR4 helps the bone marrow in creating a tumor mircoenvironment that results in the cancer metastasis. It also discusses ongoing research regarding the clinical feasibility of CXCR4 inhibitors.
24793563 This article highlights major viral pathogens that use and abuse CXCR4 and explores the possible reasons why this chemokine receptor has become "a virus's best friend". [Review]
24790097 A novel role for the really interesting new gene-domain E3 ubiquitin ligase deltex-3-like (DTX3L) in regulating CXCR4 sorting from endosomes to lysosomes.
24778234 Binding of the HIV-1 envelope protein gp120IIIB to the CD4/CXCR4/CCR5 heterooligomer was negligible, and the gp120-induced cytoskeletal rearrangements necessary for HIV-1 entry were prevented.
24778234 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
24770893 Findings suggest that CXCR4 and CXCR7 closely interact in breast cancer cells. Both are co-internalized, transduce signals and induce further biological effects partly independently of a selective stimulus or antagonist.
24763408 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
24762228 Data showed that CXCR4 and GM1 (marker of lipid rafts) were expressed in both ovarian cancer tissue and SKOV3 cells, and SDF-1 promoted the invasion and migration of SKOV3 cells, which was mediated by complete lipid rafts.
24748552 CXCR4 is overexpressed at the tumor front of prostate tumors, where it potentially promotes cell migration toward the SDF-1 centrifugal attracting gradient, as well as epithelial-mesenchymal transition.
24738139 findings support that CXCR-4 expression is downregulated by miR-9 in human fetal and neonatal megakaryocytes
24731927 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
24728301 Study shows CXCR4 influencing invasive properties of cervical carcinoma cells both in vitro and in vivo.
24722947 CXCL12-CXCR4 signaling is involved in many functions within and outside the immune system and affects morphology of immature endothelial cells and neurons, as well as homing and maintenance of tissue stem cells, including HSCs, suggesting that CXCL12 and CXCR4 are the best candidates for the primordial chemokine and receptor.[Review]
24715652 Review was to analyzing the current literature on biological effects of CXCR4 activity and its role in glioma pathogenesis
24714746 high CXCR4 expression was strongly associated with a poor outcome in patients with clear-cell renal cell carcinoma.
24711662 These findings demonstrate that C1013G/CXCR4 is an activating mutation in WM and support its role as a critical regulator of WM molecular pathogenesis and as an important therapeutic target.
24692066 CXCR4 is regulated by AU rich element-dependent posttranscriptional mechanisms that involve TTP and HuR.
24687413 CXCR4/CXCL12 chemokine axis polymorphisms may predispose to the development of inflammatory bowel disease.
24672662 CXCR4 is likely correlated with clinical recurrence of hilar-CCA and it is involved in the invasion and proliferation of human hilar-CCA cell line QBC939, indicating that CXCR4 could be a promising therapeutic target for hilar-CCA.
24658853 hepatic stellate cells can promote hepatocellular carcinoma cell invasion through the SDF-1/CXCR4 axis
24658065 The present meta-analysis indicated that high CXCR4 expression was associated with poor prognosis in ovarian cancer.
24651452 Study reveals the highly plastic and dynamic nature of CXCR4 expression in Ewing sarcoma and supports a model in which stress-induced upregulation of CXCR4 contributes to tumor metastasis.
24644030 Our results suggested that miR-494-3p might play crucial role in prostate cancer by post-transcriptional regulation to CXCR4 mRNA
24637920 Local SDF-1/CXCR4 signaling functions to preserve microvascular integrity and prevent renal fibrosis.
24635642 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
24632620 Results demonstrate crosstalk among WIP1, CXCR4 and GRK5, which may be important for the aggressive phenotype of a subclass of medulloblastomas in children.
24629239 In addition we showed the interest to inhibit the CXCR4 signaling by inhibiting both the HIF-1alpha and CXCR4/CXCL12 pathway
24621606 CXCR4-related increase of circulating human lymphoid progenitors after allogeneic hematopoietic stem cell transplantation
24618817 The hypoxia-HIF-1alpha-CXCR4 pathway plays a crucial role during the migration of human osteosarcoma cells, and targeting this pathway might represent a novel therapeutic strategy for patients suffering from osteosarcoma.
24595810 results indicate a regulatory influence of MR signaling on human T-cell migration and suggest a role for endogenous aldosterone in the redistribution of T-cell subsets to lymph nodes, involving CD62L, CCR7, and CXCR4.
24590865 Breast cancer nodal metastasis correlates with tumour and lymph node methylation profiles of Caveolin-1 and CXCR4.
24583601 CXCR4 signalling specifically regulates breast cancer stem cell activities and may therefore be important in tumour formation at the sites of metastases.
24553177 Somatic mutations in MYD88 and CXCR4 are important determinants of clinical presentation and impact overall survival in WM.
24516346 Our findings suggest upregulated expression of SDF-1 and its receptor CXCR4 in degenerated IVD
24497931 Data suggest that CXC chemokine receptor 7 (CXCR7) potentiates CXC Chemokine Receptor 4 (CXCR4) response and may contribute to the maintenance of leukemia.
24489825 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
24486245 ERbeta and CXCL12/CXCR4 expression in lung adenocarcinoma depends on sex and hormonal status, which may partly explain the sex and hormonal differences in lung cancer behavior.
24480462 identified the putative site for the binding of CXCL12 N-terminus and provided new structural elements to explain the recognition of gp120 and dimeric CXCR4 ligands
24480462 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
24475985 Overexpression of CXCR4 was significantly associated with lymph node status and distant metastasis and indicated poor overall and disease free survival in breast cancer patients.
24472670 These data suggest that CXCR4 inhibition by CTCE-9908 decreases the invasion potential in vitro, which then translated to a reduction of tumor spread with associated reduction in angiogenesis.
24470959 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
24465884 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
24461764 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
24452472 these results characterize CXCR4 structural domains and beta-arrestin1 as critical regulators of CXCR4 cell-surface expression in neuroblastoma. beta-Arrestin1 levels may therefore influence the CXCR4-driven metastasis of neuroblastoma as well as prognosis.
24448360 Blockade of CXCR4 pathway by GST-NT21MP decreased SDF-1-induced cell growth.
24422942 Chemokine receptor 4 expression indicates poorer prognosis in older patients and advanced stage or poor differentiation in colorectal carcinoma, and also serves as an indicator of lymph node and distal organ metastasis. Meta-analysis.
24416254 the correlation between SDF-1, CXCR4 and CXCR7 protein levels in endometrial cancer
24403602 CXCR4 drives epithelial mesenchymal transformation along with an up-regulation of chemokine receptors and cytokines important in cell migration, lymphatic invasion, and tumor metastasis.
24401734 Our study revealed that the expression of CXCR4 was associated with progression and invasion in patients with basal cell carcinoma.
24399074 Suppression of the expression of CXCR4 and MMP14 by vandetanib in human neuroblastoma cells inhibits cell migration and invasion.
24398989 All these data proved the utility of CXCR4, MMP-13 and beta-catenin immunohistochemical investigation in basal cell carcinoma.
24395293 Our results demonstrated the differential gene expression pattern of chemokine receptor CXCR4 in human marrow-derived MSCs stimulated with inflammatory cytokine TNF-alpha.
24390633 these results demonstrate considerable potential of high-affinity CXCR4-blocking agents for OS tumor cell homing suppressive treatment in metastasizing OS complementary to current (neo)-adjuvant chemotherapy.
24381939 We describe our studies on approaches to increase the CXCR4 expression in in vitro-expanded cord blood-derived MSCs, namely, transfection
24378831 S100A4, FOS and CXCR4, playing a major role in tumor progression and metastasis, are downregulated by sorafenib.
24376734 PGK1 appears to play an important role for neuroblastoma
24373940 CXCR4 activation with SDF-1alpha and ubiquitin results in partially synergistic effects on cellular signaling.
24373354 CXCR4/IgG-expressing plasma cells are associated with human gastrointestinal tissue inflammation.
24366360 Mutations in CXCR4 is associated with Waldenstrom macroglobulinemia.
24354491 Decreased expressions of SDF-1alpha/CXCR4 and VEGF in the placental bed could be associated with the pathogenesis of pre-eclampsia.
24330809 results show that downregulated miR-133b contributed to increased cell invasion and migration in CRC by negatively regulating CXCR4.
24318902 miR-139 targets CXCR4 and inhibits proliferation and metastasis of laryngeal squamous carcinoma cells
24318111 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
24312539 ZAP-70 enhances the migration of malignant B-cells into the supportive microenvironment found in the bone marrow mainly by enhancing signaling and migration after CXCR4 stimulation.
24312338 CXCR4 might be a downstream effector for RhoE
24312168 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
24312095 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
24288553 Overexpression of HIF-2alpha, TWIST, and CXCR4 is associated with lymph node metastasis in papillary thyroid carcinoma.
24282276 Data show that the CXC chemokine receptor 4 (CXCR4) antagonist AMD 3100 disrupted the stromal cell-derived factor 1 (SDF-1alpha)/CXCR4 axis and decreases platelet-derived growth factor B (PDGF-B) protein expression in vivo in two xenograft Ewing tumor models.
24256053 Aberrant expression of CXCR4 significantly contributes to metastasis and predicts poor clinical outcome in breast cancer.
24255072 we performed microarray expression analyses followed by mechanistic analyses to shed light on common or opposed signaling cascades initiated by CXCR4 and CXCR7 in colorectal cancer
24239175 Data indicate that levels of CXCR4 and VLA-4 did not predict acute lymphoblastic leukemia (ALL) prognosis in children, but Analysis of CXCR4 and VLA-4 levels at diagnosis in adults with ALL can provide useful information on patient prognosis.
24238971 In colorectal cancer with liver metastasis, CXCR4 expression demonstrated associations with local progression, liver metastasis, and poor overall survival.
24215935 Initial CCR5 and CXCR4 coreceptor selection by HIV-1 gp120 and approach of the ligand to the binding pocket is dominated by charge and glycosylation pattern of the viral envelope.
24215935 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
24205895 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
24200972 our results demonstrate that breast cancer cells with acquired resistance to lapatinib have a more aggressive phenotype compared with their parental counterpart, and that Src signaling and CXCR4 play an important role in this phenomenon.
24189753 our data revealed that miR-126 functions as a tumor suppressor in CRC cells by regulating CXCR4 expression via the AKT and ERK1/2 signaling pathways and might be a novel target for therapeutic strategies in CRC.
24184476 study indicated that the angiogenesis of adipose tissue-derived mesenchymal stem cells (ADSCs) is, at least partly, mediated by SDF-1/CXCR4 and SDF-1/CXCR7 axis. However, only binding of SDF-1/CXCR7 was required for proliferation of ADSCs, and CXCR7 was required for migration of ADSCs induced by SDF-1.
24175834 High CXCR4 expression promotes proliferation and invasion of pancreatic cancer.
24174685 Transgenic CXCL12- and CXCR7-deficient mice display lack of CXCR4 internalization and increased CXCR4 levels, pointing to a role for CXCR7 in controlling CXCL12 availability in this signaling system.
24170200 results indicate that miR-9 functions as a tumor-suppressive microRNA in NPC, and that its suppressive effects are mediated chiefly by repressing CXCR4 expression
24162774 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
24158961 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
24158781 There was no association between the enrichment of CXCR4 pathway and NRAS, BRAF mutation.
24157575 CXCR4 signaling has a role in cancer stem cell survival and self-renewal.
24155926 HIV-gp120 induces and regulates mucus formation in the airway epithelial cells through the CXCR4-alpha7-nAChR-GABAAR pathway.
24155926 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
24148007 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
24141785 The CXC chemokine receptor 4 (CXCR4) gene was a direct target of miR-9.
24119449 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
24101523 Data suggest that Dgcr8-mediated regulation of microRNA is likely to underlie Cxcr4/Cxcl12 signaling and associated neurodevelopmental defects.
24101191 This retrospective study shows that a high expression of CXCR4 in breast cancer is associated with earlier distant metastasis and bone metastasis in breast cancer
24098454 The presence of CXCR4-using HIV-1 prior to start of antiretroviral therapy is an independent predictor of delayed viral suppression.
24094005 Increased expression of CD164 is involved in ovarian cancer progression via the SDF-1alpha/CXCR4 axis.
24091662 CXCL12-induced CXCR4 signaling depends on the binding of high-molecular-weight hyaluronic acid to CD44.
24090041 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
24086760 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
24079738 alpha-MSH acts on melanocytes to produce melanin as well as stimulates the cells to migrate to the site where they work through CXCR4 up-regulation towards SDF-1alpha
24052640 In multivariate analysis, CCR7 staining was inversely correlated to overall survival and disease-free survival, whereas CXCR4 nuclear staining was not.
24048002 the functional role of HIV-1 gp120 V3 loop and CXCR4 residues associated with HIV-1 coreceptor activity
24048002 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
24040160 Expression of the chemokine receptor CXCR7 in CXCR4-expressing human 143B osteosarcoma cells enhances lung metastasis of intratibial xenografts in SCID mice.
24035716 There is no correlation between NPM1 mutations and CXCR4 or pCXCR4 expression, suggesting that the CXCR4 and NPM pathways act independently in adult AML.
24033610 SDF-1/CXCR4 signalling may be a new therapeutic target and strategy to promote repair and regeneration in endodontics
24032722 Subjects carrying CXCR4 rs2228014CT or TT genotypes are at significantly high risk for the development of renal cell carcinoma.
24027570 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
24025971 CXCL12 and CXCR4 have a single ligand-single receptor relationship in mediating non-small cell lung cancer migration and metastasis, and in context of NSCLC that expresses CXCR4, the CXCR4-CXCL12 axis is not involved in angiogenesis of the primary tumor
24023874 a functional cross-talk between CXCR4 and PDGFR which appears to be essential for GBM chemotaxis
24023356 Both CXCR4 and beta-catenin are abnormally expressed in pancreatic cancer. CXCR4 may be an important marker for pancreatic cancer progression
24014104 SDF-1 restores angiogenesis synergistically with VEGF upon LDL exposure despite CXCR4 internalization and degradation.
24005135 However, CXCR4 was not found in any association with poor clinical outcome and increasing visceral metastasis in BiBC patients.
23989454 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
23988662 CXCR4 may play a critical role in the metastasis of bladder transitional cell carcinoma
23987636 ETAR and CXCR4 expression levels are potential prognostic biomarkers in nasopharyngeal carcinoma patients.
23966000 An isoform of C/EBPbeta, liver-enriched inhibitory protein (LIP), is identified as a previously unrecognized transcriptional regulator of CXCR4 in breast cancer cells.
23963832 CXCR4 expression showed a distinct pattern according to the histological subtype of papillary thyroid carcinoma, although not associated with other clinicopathological parameters.
23954894 Incubation of whole chronic lymphocytic leukemia populations in vitro led to striking increases in CXCR4 expression as well as recovery of sIgM.
23936528 intratumoral CXCR4 expression was recognized as an independent prognostic marker for the overall survival of patients with gastric cancer
23935395 The results showed that CXCL12 and CXCR4 expressions were down-regulated at the stage of BMP9-induced osteogenic differentiation, in a dose- and time-dependent.
23934537 CD45(-)/CXCR4(+)/FLK-1(+) cells may provide a diagnostic tool to follow cardiac regenerative capacity and potentially serve as a prognostic marker in acute myocardial infarction.
23925152 The combination of arginine insertion and loss of N-linked glycosylation site usually confers CXCR4-tropism. Awareness of this rule will help to confirm the tropism prediction from V3 sequences by conventional rules.
23925152 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
23924922 SDF-1alpha acts through CXCR4 to induce ovarian cancer cell migration, which could be facilitated by CD40 activation.
23921147 integrin-mediated cell-ECM interactions can modulate tumor cell morphology, and regulate the expression of chemokine receptors CXCR7 and CXCR4 which are associated with the invasive phenotype and progression of prostate cancer.
23918819 Data demonstrate that ERG activates CXCR4 expression by binding to specific ERG/Ets responsive elements and via intracellular kinases that phosphorylate ERG at discrete serine residues.
23918302 nucleolin is crucial in the activation of CXCR4 signaling, which affects cell growth, migration, and invasiveness.
23911867 High glucose enhanced HIV entry into T cells by increasing expression of CXCR4 and HIF-1alpha.
23895705 Expression levels of CXCR4 and CXCL12 are correlated with the invasiveness of pituitary adenomas.
23886194 Up-regulation of CXCR3 is associated with bladder cancer.
23884589 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
23868972 Immunohistochemical analysis of human breast tumor tissues shows a significant increase of PRG expression in the invasive areas of the tumors, suggesting that this RhoGEF is associated with breast tumor invasion in vivo
23865743 our findings indicate that both CXCR4 and CXCR7 mediate glioma cell migration
23863999 CXCR4-mediated osteosarcoma growth and pulmonary metastasis are promoted by Mesenchymal stem cells through VEGF.
23856897 The aim of this article is to highlight potential therapeutics derived from peptides and proteins that show particular promise in HIV treatment.
23856244 TGF-beta1 induces upregulation of CXCR4 in human BCC cells by phosphorylation of ERK1/2-ETS-1 pathway
23849988 Loss of CXCR4 expression is associated with multiple myeloma.
23845465 Early genetic events such as the loss of RANKL and the gain of CXCR4 expressions probably facilitate the metastatic progression concomitant with the primary tumor establishment.
23842123 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
23827153 The expression of chemokine receptor CXCR4 was up-regulated in the tissue with breast cancer bone metastasis.
23822165 We concluded that CXCR4 might be a key molecule in esophageal squamous cell cancer metastasis.
23817178 CXCR4-S339 phosphorylation could serve as a novel prognostic marker in human AML
23804632 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
23802178 NMR titrations with short sulfopeptides showed that the tyrosine motifs of CXCR4 varied widely in their contributions to CXCL12 binding affinity and site specificity.
23800042 CXCR4 silencing by siRNA could suppress the proliferation, invasion and metastasis of esophageal carcinoma cell lines.
23798675 CXCR4 chemokine receptor signaling induces apoptosis in acute myeloid leukemia cells via regulation of the Bcl-2 family members Bcl-XL, Noxa, and Bak.
23794207 The SDF-1/CXCR4 axis via its activation of PI3K/AKT and MAPK in BMSCs could be the possible mechanisms underlying this function.
23794067 Stability of T cells-antigen presenting cells conjugates from patients with WHIM-mutant CXCR4 is disrupted as a result of impaired recruitment of the mutant receptor to the immunologic synapse.
23777983 Our results show CD133(+) and CD133(+)CXCR4(+) cancer cells correlate with the presence of lymph node metastasis in colorectal cancer.
23774428 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
23773308 CXCR3, CXCR4, CXCR7 have similar transmembrane helices, different conformations of N-terminal, C-terminal regions and extracellular loops, and interaction between the three receptors and CXCL11 and CXCL12 are on a hydrophobic and electrostatic basis.
23773022 This observation demonstrates that amino terminal regions of CXCR4 have an obligatory coreceptor role for dual tropic human immunodeficiency viruses.
23769877 Low CXCR4 expression was observed in the aganglionic segments of the Hirschsprung's disease patients colon.Intensive CXCR4 staining was detected in the ganglion of the colon specimens.
23765204 High CXCR4 expression is associated with invasive squamous cell vulvar cancers.
23758411 CCR6 and CXCR2 were higher in the colorectal metastasis group than in the non-metastasis group, but there was no difference between the lung and liver metastasis subgroups. CXCR4 was not different between the metastasis and non-metastasis groups.
23754844 findings show surface CXCR4 expression is dynamically altered by chemotherapy exposure in ALL and AML cells and may be driven by transcription, changes in localization of CXCR4, CXCR4 degradation or a combination of mechanisms; upregulation of surface CXCR4 may represent a mechanism of chemotherapy resistance in pediatric AML
23745959 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
23744532 Expression of miR-126 inhibited colon cancer cell viability and reduced tumor cell migration and invasion capacity by its negative regulation of CXCR4 expression.
23744460 Downregulation of CXCR4 protein expression reduced esophageal squamous cell carcinoma cell proliferation.
23734232 Data indicate that CXCL12-induced phosphorylation at CXCR4 S346/347 was mediated by GRK2/3.
23728080 Reduced CXCR4 expression is associated with multiple myeloma.
23726130 High CXCR4 expression in breast neoplasms was positively associated with lymph node metastasis and negatively with the presence of cytokeratin-positive cells in bone marrow.
23714687 miR-137 inhibits Glioblastom stem cell self-renewal and promotes their differentiation by targeting RTVP-1 which down-regulates CXCR4.
23710557 The development of pulmonary fibrosis in rheumatoid arthritis may be considered as the key event for the migration of stem cells to the injured lung through the SDF-1/CXCR4 axis.
23702796 The basic Lysine1 at the CXCL12 N-terminus, an essential residue in receptor activation, forms a strong polar interaction with the Glutamate32 in the CXCR4 extracellular region.
23697661 analysis of how CXC chemokine receptor 4 agonist modulates activity of ubiquitin through C-terminal protein modification
23692808 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
23688427 With its high receptor affinity and stability from D-amino acids, this peptide may be a new probe of CXCR4 functions in physiology and pathology and promising lead for therapeutic development.
23676502 CXCR4 induces chemoresistance by downregulating let-7a to promote YY1-mediated transcriptional activation of MYC and BCLXL in acute myeloid leukemia cells.
23672855 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
23669361 CXCL14 represents, along with CXCR7, molecules that co-evolved with the CXCL12-CXCR4 axis to modulate important physiological processes in development, stem cell maintenance, and immune responses
23659571 Mapping of key residues in the interaction between human Beta-defensin 3 and CXCR4 reveals key defensin motifs involved in protein binding.
23652361 A significant association of the NPY gene with alcohol dependence is revealed based on a G1258A polymorphism in both the Kota and Badaga populations of India.
23647548 TRAIL-induced miR-146a expression suppresses CXCR4-mediated human breast cancer migration.
23623275 Our results suggest that IBAfect-mediated delivery of CXCR4 into MSCs is a highly efficient technique that may be useful for enhancing the recruitment of systemically infused MSCs for tissue repair
23609324 CXCR4 may have a role in progression of clear cell renal cell carcinoma
23591873 findings indicate that a chemokine-controlled pathway, consisting of Galphai2, ELMO1/Dock180, Rac1 and Rac2, regulates the actin cytoskeleton during breast cancer metastasis
23575248 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
23565284 E-selectin mediated adhesion and migration of endothelial colony forming cells is enhanced by SDF-1alpha/CXCR
23563306 The SDF-1-CXCR4 axis is involved in the pathophysiology of the progression, recurrence and metastasis of malignant disease.
23555768 CXCR4 and CXCR7 have roles in in vitro growth, migration, sphere and tube formation in glioblastoma
23544621 A CXCR4 antagonist repressed both cell migration and activation of c-Jun N-terminal kinase and p38 MAPK but did not affect extracellular signal-regulated kinase 1/2 phosphorylation.
23528817 CXCR4 has an unexpected role in inhibiting keratinocyte proliferation and mitigating the effects of proliferative T helper type 17 cytokines.
23526079 High CXCR4 expression correlates with Stat3 phosphorylation in bladder cancer.
23497377 expressions of MIF and CXCR4 proteins in tumor cells and TILs have different clinically predictive values in esophageal squamous cell carcinoma
23497290 Growth factor receptor/PDGFR-Src-mediated dysregulation of CXCR4 signaling promotes medulloblastoma cell migration.
23495012 provide the novel evidence that CXCR4-expressing non-seminoma cell lines 833ke and NTera2/D1 do not invade in response to CXCL12
23490053 Potentiation of CXCR4 signaling by US27 could represent a novel strategy by which human cytomegalovirus targets virus-infected cells to the bone marrow in order to expand the reservoir of latently infected cells.
23472074 emodin exerts its anti-metastatic effect through the downregulation of CXCR4 expression
23472069 up-regulation of TPST-1 and tyrosine sulfation of CXCR4 by LMP1 might be a potential mechanism contributing to nasopharyngeal carcinoma metastasis
23469143 ChemR23 forms homomers, and provide data suggesting that ChemR23 also forms heteromers with the chemokine receptors CCR7 and CXCR4.
23468933 nuclear CXCR4 may be a mechanism underlying prostate cancer recurrence, increased metastatic ability and poorer prognosis after tumors have been treated with therapy that targets plasma membrane CXCR4
23449229 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
23446039 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
23443279 Our results also showed that EGFR and CXCR4 are potential therapeutic targets for NSCLC and that simultaneous inhibition of EGFR and CXCR4 in NSCLC patients with concomitant expression of both CXCR4 and EGFR may be an effective treatment strategy.
23434321 Study provides evidence that the CXCR4/CXCL12 axis is essential for Malignant peripheral nerve sheath tumors (MPNST) tumor progression. Specifically, the autocrine activation of CXCR4 by CXCL12 triggers intracellular PI3-kinase and beta-catenin signals to promote G1 to S phase transition in MPNST cells.
23421710 CRF51_01B and CRF01_AE-infected individuals have higher prevalence of CXCR4-usage compared to subtype B infected individuals.
23395387 Ethnically divergent populations show clear differences in both CXCR4 density and CXCL12 plasma levels which may influence the course of cancer and HIV-1 infection.
23389465 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
23369572 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
23350534 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
23349771 Data indicate associations of SNPs in eight loci CXCR4, HHEX, FOXA2, NGN3, TCF7L2, FLJ39370 (C4orf32), LOC646279 (RPL21P7) and THADA with body mass index (BMI) and weight.
23344887 The CXCL12/CXCR4/CXCR7 system appears to be directly involved in microvessel growth, its members being differentially expressed in angiogenically activated microvessels and vascular sprouts.
23343425 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
23341955 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
23331013 study found CXCR4 was expressed more frequently in triple-negative breast cancers (TNBCs) than in other subtypes; expression level is significantly related to tumor size, advanced TNM stage, shorter overall- and disease-free survival; data indicate CXCR4 might exert its function exclusively in TNBC patients
23330719 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
23326587 Adenosine increases the migration of EPC. The mechanism involves A(2B) receptor activation, decreased expression of miR-150 and increased expression of CXCR4.
23322021 Studies indicate involvement of the CXCR4 receoptor/CXCL12 chemokine signaling axis in non-small-cell lung cancer (NSCLC) metastasis to the brain.
23321466 CXCR4 overexpression is associated with high Gleason score prostate tumors, but that it is independent of the TMPRSS2-ERG rearrangement.
23297034 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
23288365 Up-regulation of CXCR4 by inhibiting glycogen synthase kinase (GSK)-3beta enhances mesenchymal stromal cell migration.
23279723 This review will focus on the signaling and effects of the widespread chemokine CXCL12 and its long known G protein-coupled receptor CXCR4 and the recently discovered non-G protein-coupled receptor CXCR7. [review]
23263827 We conclude that the expression of CXCR4 is a useful prognostic factor for patients with myelodysplastic syndrome
23259294 SDF-1 and CXCR4 protein are highly expressed in laryngocarcinoma and in metastatic lymph node tissue. Expression is correlated with lymph node metastasis, clinical stage and pathological grading.
23244336 Systemic Lupus Erythematosus leukocytes displayed reduced levels of CXCR4 and CXCR7 transcripts.
23231927 In VIPoma, defects in the mismatch repair system especially in MSH2 may contribute to carcinogenesis, and increased CXCR4 may be associated with liver metastasis.
23224761 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
23223950 Report significant up-regulation of CXCR4+ and KDR+ monocytes following myocardial infarction.
23223005 loss of Polycomb repressive complex 2-dependent histone H3 Lys27 trimethylation activates HIF-driven CXCR4 expression in support of chemotactic cell invasion
23219524 These results suggest that transdomain 4 (TM4) and ECL2 undergo conformational changes during CXCR4 activation and also demonstrate how TM4 is an important feature for the binding of anti-HIV compounds.
23216236 In terms of five molecular subtypes of breast cancer, the differences in CXCR4 protein expression were significant.
23202514 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
23197643 Priming with SDF1 upregulates mesenchymal stem cell CXCR4 engraftment and bone mechanics in a mouse model of osteogenesis imperfecta.
23177198 CXCR4 triggers macropinocytosis, which may have implications for the cellular uptake of oligoarginine cell-penetrating peptides and internalization of HIV.
23177198 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
23160836 Findings show a novel mechanism by which DARPP-32 promotes cell invasion by regulating CXCR4-mediated activation of the MT1-MMP/MMP-2 pathway.
23148226 Heparin oligosaccharides inhibit chemokine (CXC motif) ligand 12 (CXCL12) cardioprotection by binding orthogonal to the dimerization interface, promoting oligomerization, and competing with the chemokine (CXC motif) receptor 4 (CXCR4) N terminus
23143844 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
23133664 Dasatinib inhibits CXCR4 signaling in chronic lymphocytic leukaemia cells and impairs migration towards CXCL12
23082154 The positive correlation between HER2- and CXCR4-expression was validated in esophageal cancer patients.
23075330 Data indicate that Wnt5a mRNA level was correlated positively with CXCR4 mRNA level in Ewing sarcoma (ES) specimens.
23053994 SDF1-3'A and CXCR4 gene polymorphisms may not be risk factors for the susceptibility to prostate cancer.
23046610 Levels of C-erbB-2, CXCR4 and ER-alpha in patients decreased after they received neo-adjuvant chemotherapy.
23043104 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
23043103 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
23039915 High expression of CXCR4 is associated with renal cell carcinoma.
23023480 hypoxia upregulates CXCR4 in gastric cancer cells in a HIF-1alpha-dependent manner, and upregulation of CXCR4 plays a role in cancer cell migration and invasion
22995914 CXCL12/CXCR4 protein signaling axis induces sonic hedgehog expression in pancreatic cancer cells via extracellular regulated kinase- and Akt kinase-mediated activation of nuclear factor kappaB
22987307 CXCL12 protects human neural stem cells from apoptotic challenges through CXCR7- and CXCR4-mediated endocytotic signaling.
22980333 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
22954962 Chimeric env functional studies suggest that the V3 loop is necessary but often not sufficient to impart CXCR4 utilization.
22954962 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
22952422 SDF-1alpha-CXCR4 signaling represents a microenvironmental factor that can maintain mTOR pathway fidelity to promote resistance to mTOR-targeted therapy in pancreatic cancer by a variety of mechanisms.
22941282 The TGF-beta T869C polymorphism and its expression correlated with CXCR4 expression in breast cancer patients.
22936065 CXCR4 expression is associated with nodal manifestation and a more advanced stage of lymphomas and hence, might serve as useful clinical prognostic marker.
22932666 the role of the CXCL12-CXCR4 axis as a novel chemoattractant for LECs in promoting lymphangiogenesis, and support the potential application of combined targeting of both chemokines and lymphangiogenic factors in inhibiting lymphatic metastasis.
22925564 Targeting the CXCL12/CXCR4 axis with BKT140 attenuated non-small cell lung cancer cell tumor growth and augmented the effects of chemotherapy and radiotherapy.
22923991 The 18 mer peptide T22 (a peptide that binds CXCR4) nanoparticles efficiently penetrated target cells via a rapid, receptor-specific endosomal route and was found to be a promising CXCR4 targeting agent.
22916293 Data suggest that CXCR7 elicits anti-tumorigenic functions, and may act as a regulator of CXCR4/CXCL12-mediated signaling in neuroblastoma.
22914607 CXCR4 expression could be incorporated into the risk assessment of patients with acute myeloid leukemia.
22908191 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
22902648 CXCR4 is essential for ovarian tumor cell proliferation and invasion.
22897429 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
22885527 a complicated cross-talk via the CXCL12/CXCR4 signal at the maternal/fetal interface in early human pregnancy.
22871210 Flow cytometry analysis was performed to detect distinct subsets with CD133 and CXCR4 markers in human primary and metastatic CRC tissues. In human specimens, CD133(+)CXCR4(+) cells were higher in liver metastases than in primary colorectal tumors.
22852142 Spica Prunellae and Herba Andrographitis inhibited CCR5 and CXCR4 expression in vitro, by down-regulating these promoters.
22848341 CsA may promote EGFR activation via CXCL12/CXCR4 axis, and EGFR downstream ERK signaling pathway may be involved in the CsA-induced proliferation of human trophoblast cells.
22847686 High CXCR4 expression is associated with salivary gland metastasis.
22842622 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
22830600 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
22808111 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
22802411 These results provide a novel causal link between SDF-1alpha-induced chemotaxis, degradation of Bim(EL), and the development of CD4 T cell memory.
22784557 CXCL12-CXCR4 axis maintains NSCs and serves as an emergent salvage signal for initiating endogenous stem cell-based tissue repair.
22779681 SDF-1alpha analogues with a modified N-methylated main chain retain significant CXCR4 binding yet lose signaling activities.
22767589 Our results suggest that the SDF-1/CXCR4 axis is important in angiogenesis and tumor cell intravasation
22745793 The results demonstrate that SOCS1 and SOCS3 each play a functionally distinct role in modulating TLR3, JAK/STAT, and CXCR4/CXCR7 signaling in hMSC.
22732432 Different gp41 and gp120V3 amino acid changes are associated with CXCR4 and CCR5 usage.
22732432 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
22728273 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
22727731 we provide additional evidence that the anti-apoptotic effect of stromal-derived factor-1 is mediated by interaction with CXCR4.
22706111 In this review we describe the clinical significance of CXCR4 and its ligand, as well as the role of CXCR4 and its gene polymorphisms in disease susceptibility.
22699677 CXCR4 mRNA (p < 0.001) and CXCL12 mRNA (p = 0.02) relative expressions were significantly correlated with relative IFNgamma mRNA expression in breast cancer.
22692798 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
22689289 Both CXCR3 and CXCR4 are involved in metastasis of colorectal cancer to lymph nodes, lungs and liver.
22688512 sphingomyelin in lipid rafts decreases responsiveness to signaling by the CXCL12/CXCR4 pathway
22683307 REVIEW: CXCR4/CXCL12 axis' role in cancer
22682478 Through upregulation of CXCR4, cell migration of circulating angiogenic cells was promoted by adiponectin.
22673499 The CXCR4 receptor could be effectively overexpressed in mesenchymal stem cells in culture.
22644306 the chemokine receptor CXCR4 maintains a cancer progenitor population in tamoxifen-resistant MCF7 cells through aryl hydrocarbon receptor signalling
22634622 Plasmacytoid dendritic cells (pDCs) constitutively migrate into the splenic white pulp in a manner dependent on chemokine receptors CXCR4 and CCR7.
22596258 In addition to truncating mutations in the C-terminal domain of CXCR4, WHIM syndrome may be caused by a single charge-changing amino acid substitution in this domain, E343K, that results in increased receptor signaling.
22582975 The influence of transforming growth factor-alpha, cyclooxygenase-2, matrix metalloproteinase (MMP)-7, MMP-9 and CXCR4 proteins involved in epithelial-mesenchymal transition on overall survival of patients with gastric cancer.
22568557 significant increase in the surface expression of CXCR4 in CD4(+) T cells from elderly donors, relative to those from the young
22554649 Studied the genetic variations in open reading frames and regulatory regions of CCR5, CXCR4 and SDF-1. Results show the great genetic heterogeneity within CCR5, CXCR4 and SDF-1 in Chinese Han, Mongol and Uyghur ethnic populations.
22549810 The ER-CXCL12-CXCR4 signaling axis may represent a promising target for development of therapeutics for ER+ ovarian cancers.
22547906 Mobilization of CD34+CXCR4+ cells in acute MI shows significant positive correlation with improvement of LVEF after 1 year
22541097 Although the expression of CXCR4 was not different between myelodysplastic syndrome patients and normal controls, there was a positive correlation between p57kip2 and CXCR4 in MDS patients.
22537596 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
22532631 IL-17A combined with TNFalpha contributes to progression of rheumatoid arthritis through their effect on synoviocyte aggressiveness resulting partly from activation of the CXCR4/stromal cell-derived factor 1 and hypoxia-mediated pathways.
22526457 low CCL27/CCR10 and CXCL12/CXCR4 intratumoral mRNA ratios are associated with melanoma progression
22513895 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
22496601 Results indicated that CXCL12/CXCR4 axis may play roles from early steps of oral malignant transformation and contribute to the progress of oral carcinogenesis.
22496149 UL33 and UL78 heteromerize with host CCR5 and CXCR4 impairing their HIV coreceptor activity.
22495096 CsA can promote the crosstalk between cytotrophoblast and DSC through up-regulating CXCL12/CXCR4 interaction via MAPK signaling, resulting in the increased numbers of and invasion by human cytotrophoblast cells
22490156 Elevated levels of CXCR4 and MMP-9 are found in small cell lung cancer tissues. CXCR4 expression might be correlated with bone metastasis. CXCR4 is an independent prognostic factor for disease-free survival in SCLC.
22479424 X4 HIV-1 gp120 is pro-fibrogenic through its interactions with CXCR4 on activated human hepatic stellate cells.
22479424 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
22472349 CXCR4 and CXCR7 are frequently co-expressed in human pancreatic cancer tissues and cell lines.
22471472 High expression of CXCR4 was associated with not only increased risk for disease progression but also treatment response.
22470838 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
22463589 High CXCR4 expression correlates with a poor response to sunitinib in metastatic renal cancer.
22450749 SDF-1/CXCR4 modulates the non-canonical Hh pathway by increasing the transcription of SMO in a ligand-independent manner.
22430135 These findings suggest a possible role for the CXCL12/CXCR4 axis in the metastatic evolution of non-small-cell lung cancer
22427929 CXCR4 is required for Glioblastoma multiforme tumor growth.
22427920 CXCR4 is expressed in mesendoderm and endoderm, but is not expressed in mesoderm.
22377565 CXCR4 is a strong independent prognostic biomarker associated with distant metastatic recurrence in pancreatic adenocarcinoma.
22370717 HMGB1-induced recruitment of inflammatory cells depends on CXCL12. HMGB1 and CXCL12 form a heterocomplex that acts exclusively through CXCR4 and not through other HMGB1 receptors.
22370645 data provide the first evidence that CXCR4 signaling has a functional role in the maintenance of stemness of non-small cell lung cancer cells
22366438 results point out the importance of SDF-1/CXCR4 interaction in laryngeal and hypopharyngeal squamous cell carcinoma angiogenesis. IL-8 would be triggered by the cooperation of SDF-1 and CXCR4 through an Akt-dependent pathway
22362916 Activation of the SDF-1/CXCR4 axis can contribute to early stages of gastric carcinogenesis primarily through recruitment of stromal cells and modulation of the progenitor niche.
22359577 CXCL4/CXCR12 pathway is activated in the CD44(+)/CD133(+) prostate progenitor population and affects differentiation potential, cell adhesion, clonal growth and tumorigenicity
22342838 Progesterone participates in the acquisition and progression of HIV-1 infection by modulating CCR5 and CXCR4 expression.
22333149 The expression of SDF-1/CXCR4 is significantly abnormal in myelodysplastic syndrome patients, and is correlated with apoptosis and angiogenesis.
22332354 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
22313935 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
22299827 ED is a novel blocker of CXCR4 expression and, thus, has enormous potential as a powerful therapeutic agent for metastatic cancer.
22297516 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
22292949 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
22291694 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
22286875 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
22275353 Overexpression of an AIP4 catalytically inactive mutant and a mutant that shows poor binding to STAM-1 fails to enhance CXCR4-induced ERK-1/2 signaling.
22266861 data suggest that mutations in TP53 and amplification of the CXCR4 gene locus may be early events in the development of HGSOC, and associated with chromosomal instability
22266857 CXCR7+ cells promote growth and metastasis of CXCR4+ breast cancer cells.
22253872 Stimulation with CXCL12 induced increased chemotactic cell motility and blocking CXCR4 decreased extravasation of highly metastatic MDA-MB-231 cells.
22245379 These findings support the development of novel therapeutics targeting the CXCL12/CXCR4 axis as an ancillary to those targeting the androgen/AR axis to effectively treat castration resistant/recurrent prostate tumors.
22242160 HGF induced functional CXCR4 receptor expression in breast cancer cells. The effect of HGF was specifically mediated by PKCzeta activity.
22238325 Rac1 positively regulates CXCR4 function and identifies the Rac1-CXCR4 axis as a new target for preventing HIV-1 infection.
22237899 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
22232208 data implicate an important role for the CXCR4/CXCR7/SDF-1 pathway in the pathogenesis of hemolytic uremic syndrome
22226668 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
22220905 Methotrexate chemotherapy transiently alters bone marrow cellularity and composition and the reduced cellularity may be associated with deregulated CXCL12/CXCR4 chemotactic signalling.
22220212 The DNA methylation status of both CXCR4 and CXCL12 genes could be used as a biomarker for prognosis in breast cancer.
22219640 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
22200669 Loss of breast cancer metastasis suppressor 1 promotes ovarian cancer cell metastasis by increasing chemokine receptor 4 expression.
22175768 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
22169298 The SDF-1/CXCR4 axis enhances the ability of cell adhesion and migration through PI3K signaling pathway in patients with myelodysplastic syndrome.
22169254 CXCR4 may play a critical role in the progression of clear cell carcinoma of the ovary.
22157596 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
22152016 CXCR4 and CXCR7 play different roles in metastasis, with CXCR4 mediating breast cancer invasion and CXCR7 impairing invasion but enhancing primary tumor growth through angiogenesis.
22147802 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
22147793 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
22133596 This study demonistrated that positive correlations between high hypoxic score, obtained CA9 and CXCR4 expression, and main pathological data of poor prognosis, including higher tumour grade, size and N1 status and reduced patients' survival.
22124968 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
22114110 Data suggest that first-trimester decidual stromal cells express plasma membrane CXCR4; trophoblast-derived/secreted CXCL12 promotes this CXCR4 expression and promotes invasion of decidual stromal cells via interaction with CXCR4.
22103834 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
22103833 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
22101518 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
22101471 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
22086059 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
22084248 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
22075627 CXCR4 expression in metastatic liver tumors together with the upregulation of CXCL12 in hepatocytes may help to predict the clinical outcomes of patients with CLM after hepatectom
22074556 forced expression of SLUG elevated CXCR4 and CXCL12 expression in human prostate cancer cell lines
22052462 findings define a new medulloblastoma subgroup characterized by a functional interaction between the SHH and CXCR4 pathways, and they provide a rationale to clinically evaluate combined inhibition of SHH and CXCR4 for medulloblastoma treatment
22039044 Ubiquitin mimics the structure-function relationship of chemokines and interacts with CXCR4 through a ligand specific binding site on the receptor
22025564 Findings indicate a central role for PGE(2) in myeloid-derived suppressor cells accumulation triggered by the CXCL12-CXCR4 pathway, providing a powerful rationale to target PGE(2) signaling in ovarian cancer therapy.
22023092 Also the HIV-1 SI phenotype was associated with lower CD4(+) T cell counts all along the course of infection. These findings highlight the need to evaluate the presence of SI/CXCR4 variants early at primary infection.
22018245 The data described herein have identified a unique epitope of CXCR4 whose ligation not only directly inhibits X4 HIV-1, but also indirectly inhibits R5 HIV-1 infection by inducing higher levels of natural CCR5 ligands.
21994672 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21994458 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21986127 High expression of CXCR4 is associated with gallbladder cancer.
21985848 Thus, hampering the SDF-1/CXCR4 cross-talk is a promising strategy to suppress metastasis.
21969820 cells expressing CD133+ and the stromal cell-derived factor 1alpha (SDF-1alpha) receptor CXCR4 were enriched in chemotherapeutic-resistant colorectal cancer cells
21951552 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21948620 Results provide strong evidence supporting that limbal SC function depends on close physical association with their native NCs via SDF-1/CXCR4 signaling.
21948112 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21934106 signaling-selective inhibition of the CXCR4-Galpha(13)-Rho axis prevents the metastatic spread of basal-like breast cancer cells.
21931863 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21914280 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21909361 Recombinant human osteopontin up-regulates MMP-2 through the SDF-1alpha/CXCR4 axis.
21909080 CXCR4 expression and BRAF mutation status could cooperatively induce and promote a more aggressive phenotype in papillary thyroid carcinoma through several pathways and specifically increase the tumors' spread outside of the thyroid gland.
21906874 Neuroblastoma expressed both of the SDF-1 receptors CXCR4 and CXCR7. shRNA knockdown showed that these receptors were responsible for the migration of neuroblastoma towards mesenchymal stromal cells.
21906588 In this first demonstration of SDF-1-CXCR4-induced microRNAs in breast cancer, it suggests that this signaling axis may promote tumorigenesis via microRNA regulation.
21902590 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21887463 Significantly higher levels of CXCR4, DNMT3A, DNMT3B and DNMT1 transcript (p=0.0058, 0.0163, 0.0003 and <0.0001, respectively) levels in cancer tissue as compared to normal samples.
21878648 Chemokine CXCL12 uses CXCR4 and a signaling core formed by bifunctional Akt, ERK1/2, and mTORC1 proteins to control chemotaxis and survival simultaneously in mature dendritic cells.
21835796 These results suggest that the structural integrity of the gp120-gp41 interface is important for efficient CXCR4-mediated monocyte-derived macrophages entry of certain HIV-1 strains.
21835796 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21831961 These results indicated that PEA3 could activate CXCR4 promoter transcription and promote breast cancer metastasis.
21818756 the SDF-1/CXCR4 axis might facilitate the migration of circulating B cells into tuberculous pleural space
21802140 High CXCR4 is associated with high-grade myelodysplastic syndromes.
21802105 Here, the authors demonstrated in two different assay systems that His-tagged MC148R1 of Molluscum contagiosum virus displaces the interaction between CXCL12alpha and CXCR4.
21760891 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21740294 Data suggest that the therapeutic efficacy by CXCR4 antagonists appeared to involve interference with the tumor-promoting signals delivered by CXCL12.
21738044 CXC chemokine receptor 4 plays a critical role in the metastasis of human ovarian cancer possibly through modulating the Wnt/beta-catenin pathway.
21731496 detailed description of the mutational pathways in V3 during the transition from CCR5- to CXCR4-usage in natural HIV-1 infection
21730065 CXCR7/CXCR4 heterodimer constitutively recruits beta-arrestin to enhance cell migration.
21728385 Hip has been identified as a novel substrate of GRK5 in vitro and in cells, and phosphorylation of Hip by GRK5 plays a role in modulating CXCR4 internalization
21723943 CXCR4 and CCR5 homo or heterodimers rely on different Rab GTPases for the trafficking between the endoplasmic reticulum and plasma membrane in Jurkat cells.
21720384 Stable miR-302-367 cluster expression results in inhibition of CXCR4 leading to the disruption of the sonic hedgehog (SHH)-GLI-NANOG network.
21705626 The CXCR4-T cell receptor heterodimer stimulates T cell migration and activation of ERK MAPK and downstream AP-1-dependent cytokine transcription in response to stromal cell-derived factor-1
21695171 17-beta-estradiol-regulation of the CXCL12 axis components and their involvement in the growth of breast cancer cells
21680174 RNAi-mediated silencing of VEGF-C inhibits non-small cell lung cancer progression by simultaneously down-regulating the CXCR4, CCR7, VEGFR-2 and VEGFR-3-dependent axes-induced ERK, p38 and AKT signalling pathways.
21676905 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21670103 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21668366 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21663455 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21656184 Our studies reported here show that ORL1 exhibits the ability to cross-desensitize CXCR4 in both primary leukocytes and hematopoetic cell lines
21655330 Study observed specific alterations in the abundance of CD4(+)/CCR5(+) and CD4(+)/CXCR4(+) T-cells, and concentrations of immune proteins across different HIV clades and as infection progresses.
21655198 Data suggest that CXCR7 may interact with CXCR4 at the intracellular level, possibly affecting CXCR4 trafficking and/or coupling to other proteins.
21633638 CXCR4/SDF-1 axis is involved in lymph node metastasis of gastric carcinoma.
21631268 CXCR4 is expressed in chondrosarcomas with expression levels higher in high-grade chondrosarcoma cells than in low-grade specimens.
21630055 CXCL12 and CXCR4 are related to formation of gastric tumors and lymph node metastasis
21627959 these studies add to the body of knowledge on the regulatory role of PTEN in CXCR4-mediated cancer progression.
21624427 Studies indicate that CXCR4 and stromal-cell-derived factor 1alpha axis play a significant role in stem cell mobilization.
21623830 data suggest that the SDF-1/CXCR4 signalling could be used to manipulate the human fertilization, to improve both the outcome of physiological or assisted reproduction, and to develop new contraceptive methods, by development of SDF1 or CXCR4 antagonist
21623238 CXCR4 overexpression is associated with stage IV non-small cell lung cancer.
21618080 The CXCL12/CXCR4 signaling pathway is arguably the most conserved mechanism in directing stem cell migration in the embryo and adult mammals. (Review)
21607655 Our results demonstrate that altered expression and distribution of SDF-1/CXCR4 in MSCs may contribute to SDF-1 deficiency in the plasma of AML patients.
21607621 No significant association between the SDF-1 and CXCR4 polymorphisms and endometrium cancer risk.
21573951 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21569838 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21569409 These results show that HIV-1 gp120V3 and several specific amino acid changes in HIV-1 gp41 are associated together with CXCR4 and/or CCR5 usage.
21569409 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21567400 The effect of SDF-1 on colorectal cancer cell signaling and urokinase-type plasminogen activator (uPA) expression is mediated by the CXCR4/beta1 integrin axis.
21555814 Several mutations in gp41 were significantly associated with CCR5- or CXCR4-using viruses in two independent well-defined cohorts.
21555814 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21553525 The expression level of CXCR4 in the laryngeal squamous carcinoma tissue was positively correlated with vascularization.
21537329 Lentiviral depletion of CXCR4 in IEC-6 cells similarly altered ERK1/2 activity and prevented chemokine-stimulated migration
21530075 findings reveal that CXCR4 expression exerts a critical role in early stages of breast lesions, which may explain the high frequency of CXCR4 expression detected in DCIS
21527066 The expressions of CXCL12/CXCR4 and CXCL16/CXCR6 were significantly higher in epithelial ovarian carcinomas than in normal epithelial ovarian tissues or benign epithelial ovarian tumors. Expression of CXCR4 was related to lymph node metastasis.
21525208 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21521526 data show that in the setting of hypoxia and CXCR4 up-regulation in Treg, CXCL12 expression may have the negative consequence of enhancing Treg recruitment and suppressing the anti-tumour immune response
21518481 SDF-1 and CXCR4 express at a high level in children with AL, which closely relates with the type of leukemia and the migration and infiltration of leukemia cells in bone marrow.
21513481 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21506920 Pathogenesis of the WHIM syndrome is mediated by CXCR4 hyperfunction, leading to increased responsiveness to its unique ligand CXCL12 (also known as SDF-1). (Review)
21474836 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21468602 The high in vitro metastatic potential of human bladder carcinoma cell sublines is closely associated with increased CXCR4 expression.
21463876 Interaction between carcinoma-associated fibroblasts and tumor epithelial cells through the CXCL12/CXCR4 axis plays a role in non-small cell lung cancer tumor proliferation.
21459858 implications for the binding of CXCL12 and gp120 of HIV-1 at 'site 2' of CXCR4 are of great value for understanding the signal transduction via the receptor
21459858 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21454012 suppression of CXCR4 inhibits EGFRvIII-mediated breast cancer cell invasion and proliferation
21447649 This is the first report detailing the initiation of a KOR-induced JAK2/STAT3 and IRF2 signaling cascade, and these pathways result in substantial down-regulation of CXCR4 expression.
21435112 Increased levels of circulating SDF-1alpha and CD34+ CXCR4+ cells may play an important role in the vasculogenesis of moyamoya disease.
21402361 the capacity for HIV-1 to use the chemokine receptor CXCR4 for entry determines whether a virus will enter multipotent versus differentiated progenitor cells
21381021 data demonstrate the cooperation between CCL5 and CXCL12, which has implications in migration of monocytes/lymphocytes during inflammation and in HIV-1 infection
21373976 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21357602 CXCR4 expression is highest in the early proliferative phase of the menstrual cycle in endometrium.
21350711 Data suggest that SDF-1 down-regulates the E-cadherin/beta-catenin complex expression in HT29 cells by decreasing mRNA synthesis and increasing beta-catenin phosphorylation.
21349998 Studies indicate that CXCL12 binds to CXCR4 and CXCR7 and promote cell survival.
21349294 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21349176 A comparative CXCL12/CXCR4 expression analysis was performed to assess the effect of external CXCL12 stimulation on migration of CRC cells without and with CXCR4 inhibition.
21346189 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21321123 results suggest that HIV-mediated early actin polymerization may directly regulate the CXCR4 receptor during viral entry and is involved in viral DNA synthesis.
21312239 Data show that small interfering RNA against CXCR4 inhibited the SDF-1alpha-induced increase of IL-6 expression.
21310296 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21304904 CXCR4 rs2228014 polymorphisms from donor or recipient did not affect the incidence of acute rejection.
21300944 These findings support a model in which NPY genetic variation predisposes certain individuals to low NPY expression, thereby increasing neural responsivity to negative stimuli within key affective circuit elements.
21295814 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21292343 there is a significant association between the polymorphisms of CXCL12 and CXCR4, and the susceptibility to and prognosis of non-small cell lung cancer
21284907 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21284902 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21284900 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21264298 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21238532 Data show that very small embryonic-like stem cells were isolated from CD34(+)/CD133(+)/CXCR4(+)/Lin(-) CD45(-) immature cells from bone marrow.
21205837 These results strongly suggest the underlying mechanism of CXCR4 promoting Tca8113 migration and invasion by regulating MMP-9 and MMP-13 expression perhaps via activation of the ERK signaling pathway.
21188555 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21186999 This review presents current knowledge of the mechanisms through which SDF-1/CXCR4 signaling promotes restoration of hematopoiesis by regulating the homing and engraftment of hematopoietic stem/progenitor cells.
21179547 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21178277 The WHIM syndrome is mostly linked to inherited heterozygous autosomal dominant mutations in the gene encoding CXCR4 (Review)
21165786 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21158728 discuss the different aspects of CXCL12/CXCR4 biology as well as the development and anti-cancer/stem cell mobilizing activity of CXCR4 antagonists
21156016 CXCR4 is expressed in about one third of patients with clinically localized prostate cancer
21152581 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21139054 Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells.
21138752 CXCR4 antagonist 4F-benzoyl-TN14003 inhibits leukemia and multiple myeloma tumor growth.
21128884 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21127401 CXCR4 was overexpressed in tumours and had a significant prognostic value at the univariate analysis.
21110890 We detected differential expression of CXCR4 between portal vein tumor thrombus and hepatocellular carcinoma by an immunohistochemical assay
21106747 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21093051 Data show that the expression of CD49d is strongly associated with expression of the chemokine receptor CXCR4 suggesting a co-ordinated role for these molecules in the trafficking of CLL cells to the lymphoid tissues.
21087446 CXCR4 expression on peripheral blood immature plasma cells was also up-regulated selectively in patients with ulcerative colitis.
21087342 CXC chemokine receptor 4 (CXCR4) was found to be expressed in many tumors and significantly correlated with invasion, angiogenesis, metastasis, and prognosis.
21082982 CXCL12 interaction with CXCR4 recpetor results in effects as varied as cell migration, proliferation and survival or apoptosis (Review)
21080209 Enoxaparin (LMWH) inhibits the formation of hepatic metastasis of colon cancer by disrupting the interaction of CXCR4 and CXCL12.
21076047 Data suggest that loss of PTEN permits CXCR4-mediated functions in prostate cancer cells through the ERK1/2 pathway.
21071054 Basic amino acid substitutions at position 11 of HIV-1 env sequences were strong determinants of CXCR4-mediated entry but required multiple compensatory mutations to overcome associated reductions in infectivity.
21071054 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
21070597 these data provide further evidence that CXCR4(R334X) is a gain-of-function mutation
21059341 NF-kappaB-regulated CXCL12/CXCL4 autocrine system is essentially involved in the invasiveness of ovarian cancer.
21052687 Levels of circulating CXCR4-positive cells are decreased and negatively correlated with risk factors in cardiac transplant recipients.
21048156 Data show that coculture of ALL cells with MSCs induced on the lymphoblast plasma membrane the expression of a signaling complex formed by hERG1, the beta(1)-integrin subunit, and the chemokine receptor CXCR4.
20981786 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
20972812 Results show that uPAR expression regulates the adhesive and migratory ability of CXCR4-expressing cells through a mechanism involving fMLP receptors and alpha-v integrins.
20967243 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
20956518 CXCR4 and CXCR7 cores share ligand-binding surfaces for the binding of the synthetic ligands, indicating that CXCR4 inhibitors should be tested also on CXCR7.
20953377 HIF-1, CXCR4, and VEGF high expression levels in colon cancer were correlated positively with TNM stage, lymph node involvement, and distant metastasis.
20947116 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
20942936 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
20929726 five independent crystal structures of CXCR4 bound to an antagonist small molecule IT1t and a cyclic peptide CVX15 at 2.5 to 3.2 angstrom resolution
20923564 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
20921899 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
20876529 USP8 promotes trafficking and degradation of CXCR4 at the sorting endosome.
20865359 up-regulation of CXCR4 is associated with colorectal cancer progression.
20861743 Low CD4+ T-Cell Surface CCR5 density does not favour the emergence of HIV-1 X4 strains in vitro; data argue for a role of CXCR4 density, but not of CCR5 density, in the emergence of X4 strains
20861743 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
20861157 The autocrine/paracrine macrophage migration inhibitory factor (MIF)-CXCR4/CXCR7 axis plays an important pleiotropic role in rhabdomyosarcoma growth.
20859707 A negative correlation was found between apoptosis in myelodysplastic syndromes and CXCR4 expression.
20847314 Regulation of bone marrow progenitor cell trafficking by SDF-1 and CXCR4 is dependent on Src-mediated c-kit phosphorylation.
20842205 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
20829512 Dedicator of cytokinesis (DOCK)180 links CXCR4 signaling to Rac activation in order to control endothelial cell migration during cardiovascular development.
20802527 PAUF associated with the CXC chemokine receptor (CXCR4)-TLR2 complex and inhibited CXCR4-dependent, TLR2-mediated NF-kappa B activation.
20801883 Na+/H+ exchanger regulatory factor-1 is involved in chemokine receptor homodimer CCR5 internalization and signal transduction but does not affect CXCR4 homodimer or CXCR4-CCR5 heterodimer.
20797755 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
20728717 Lipopolysaccharides increased the expression of CXCR4 in dental pulp stem cells (DPCs) after 48 hours of treatment; hypoxic DPCs expressed high levels of CXCR4 as well.
20723431 Increased protein expressions of nuclear CXCR4, VEGF-C, and CK-19 are independent risk factors for developing lymph node metastasis in hepatocellular carcinoma.
20722038 CXCR4 appears to be up-regulated in multiple leukocyte subsets in systemic lupus erythematosus patients.
20710056 GBV-C coinfection in HIV-1 disease leads to reduced expression of the two major HIV-1 coreceptors, CCR5 and CXCR4, on CD4(+) T-cells in patients at an advanced stage of immunodeficiency.
20708218 The study shows platelet apoptosis resistance existing in pediatric patients with chronic immune thrombocytopenic purpura, which may be associated with enhanced CXCR4 expression and Akt activation.
20705717 Data suggest that early embryonic signals may regulate fetal-maternal crosstalk in the human endometrium by inducing CXCR4 expression via the PGE-PTGER2-mediated induction of the EGFR, PI3K and ERK1/2 pathways.
20699000 High CXCR4 expression through tumor necrosis factor-alpha is associated with gastric cancer.
20697919 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
20686090 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
20678176 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
20661426 Data provide evidence that the tumor suppressor, programmed cell death factor 4 (PDCD4), is a previously unidentified phosphorylation target of CXCL12 signaling in all Chronic Lymphocytic Leukemia cells probed.
20661303 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
20660740 crosstalk mechanism involving CXCR4/YY1 plays a role neoangiogenesis during matastasis
20651371 CXCR4 mRNA expression levels may be a potential predictive biomarker in gastric cancer.
20646838 CXCR4 expression might be a frequent and cancer-specific event in thyroid carcinoma, and it might be involved in malignancy transformation during the progression of thyroid carcinoma.
20646340 CXCL12/CXCR4 axis contributes to inflammation in usual interstitial pneumonia and non-specific interstitial pneumonia (f-NSIP) by promoting the accumulation CXCR4(+) lymphocytes.
20639728 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
20637871 Focus on the multifaceted SDF-1/CXCR4 axis in acute leukemia and how targeting this pathway could provide potential interest to eradicate the leukemia stem cells.
20629629 As described in detail in this review, the CXCR4/CXCL12 interaction produces pleiotropic effects in stem cells and plays a pivotal role in several processes related to development, tissue regeneration and development/progression of malignancies.
20629312 The expression rates of CXCR4 and VEGF were elevated in hemangioblastomas compared with the normal cerebellar tissues.
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20622011 Study show the formation of hetero-oligomeric complexes between this viral BILF1 and human CXCR4. BILF1 impaired CXCL12 binding to CXCR4 and, consequently, also CXCL12-induced signaling.
20616219 found markedly increased CXCR4 expression on neutrophils from both our G6PC3-deficient patients
20607251 Expression of the CXCR4 plays a role in CRC progression and may be associated with SDF-1alpha stimulation.
20603605 Data suggest that that ITF2 is one of the CXCR4 targets, which is involved in CXCR4-dependent tumor growth and invasion of breast cancer cells.
20599766 CXCR4 expression levels in endothelial colony forming cells (ECFCs) could be a predictive marker for success of ECFC-based angiogenic therapy.
20598333 High CXCR4 overexpression in primary tumors was predictive of worse outcomes in hormone receptor-positive, node-negative breast cancer patients.
20594957 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
20594270 This review focuses on the current knowledge of CXCR4 regulation and how deregulation of this protein may contribute to the progression of cancer.
20585037 The CXCL12/CXCR4 axis promotes, but is not absolutely required for, tumor angiomyolipoma/lymphangioleiomyomatosis cell growth and survival.
20580677 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
20578990 In patients with renal cell carcinoma, level of CXCR4 and CXCR7 expression in tumor tissue correlated with disease free survival and lymphatic metastasis; higher CXCR4 and CXCR7 expression predicts earlier relapse.
20573813 V3 and domains outside V3 of HIV-1 play roles in determining CXCR4 tropism.
20573729 CXCR4 gene transfer contributes to the enhanced in vivo reendothelialization capacity of endothelial progenitor cells.
20568229 CCL18 is an important modulator of CXCR4-dependent responses in pre-B acute lymphocytic leukemia cells via interactions with GPR30.
20563655 stromal derived factor-1 (SDF-1) and chemokine receptor (CXCR4) have roles in bone metastasis of renal carcinoma
20561415 Down-regulation of CXCR4 mRNA expression induces cell apoptosis and cell cycle arrest in Jurkat cells.
20540706 This review explores the chemokine CXCL12/receptor CXCR4 signalling pathways that regulate cellular processes under chemotherapy-treated conditions.
20530226 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
20525755 The report for the first time that high CXCR4 expression preferentially associates with metastatic Ewing's sarcoma.
20505072 Arrestin-2 via its interaction with STAM-1 modulates CXCR4 sorting by regulating the ubiquitination status of HRS.
20502526 The binding study results were confirmed on human CXCR4-expressing SupT1 cells and correlated with entry efficiency using a virus entry assay.
20492653 CXCR4 is expressed on breast cancer cells and exposure to hypoxia upregulated this expression, increasing migratory and invasive potential.
20484957 Pancreatic stellate cells can secrete SDF-1 and increase the invasion of pancreatic cancer cells through the SDF-1/CXCR4 axis.
20465832 These results demonstrate that Nef can be expressed from unintegrated DNA at functionally relevant levels and suggest a role for Nef in downregulation of CXCR4 and CCR5.
20465832 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
20462600 The chemotactic interaction between CXCR4 and its ligand CXCL12 may be a critical event during the progression of pancreatic cancer.
20460402 The CXCR4-SDF1 axis has an important role in epithelial ovarian carcinoma (EOC) metastasis by a mechanism that targets EOC metastasis.
20450430 An immunohistochemical panel, including CXCR4, could be useful in the differential diagnosis between benign and malignant well-differentiated follicular-patterned thyroid lesions
20439195 We studied a unique cohort of 21 primary lung cancers with matched adrenal metastases for the expression of CX3CR1, CXCR4, CCR6, and CCR7
20421499 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
20388803 CXCR7 is found on "differentiated" glioma cells, and the alternate receptor CXCR4 is also localized on glioma stem-like cells
20388788 proteolytic degradation of CXCL12 is characteristic of both PV and PMF; truncated forms of CXCL12, in addition to the reduced expression of CXCR4 by CD34(+) cells, lead to a profound mobilization of HSC/HPC in PMF
20386750 Vascular CXCR4 expression was significantly associated with higher local tumour extent as well as higher UICC-stages
20380698 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
20349215 These data indicate that CXCR4 and VEGF expression is highly correlated with metastatic progression in patients with osteosarcoma
20338046 We investigated methylation patterns in the promoter regions of ABCB1, ATM, BRCA1, CDH3, CDKN2A, CXCR4, ESR1, FBXW7, FOXC1, GSTP1, IGF2, HMLH1, PPP2R2B, and PTEN75 in well-described pre-treatment samples from locally advanced breast cancer
20299967 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
20228059 uncovers a fundamentally new aspect of the role of ubiquitin in biology, has implications for the understanding of CXCR4-mediated events, and is expected to facilitate development of new therapeutic avenues for a variety of diseases
20206813 Report the angiogenic effects of stromal cell-derived factor-1 (SDF-1/CXCL12) variants in vitro and the in vivo expressions of CXCL12 variants and CXCR4 in human critical leg ischemia.
20196768 Data show that expression of CXCR4 in unrestricted somatic stem cells decreases with passage number, and that VEGF increases surface expression and mRNA level of CXCR4 in USSCs, while IGF-1 decreases its expression.
20177796 Stromal CXCR4 and CXCL12 expression is associated with distant recurrence and poor prognosis in rectal cancer after chemoradiotherapy.
20159979 AMSH interacts with ESCRT-0 to regulate the stability and trafficking of CXCR4.
20154716 CXCR4 mRNA and protein expression were upregulated in TGF-beta1-treated MCF-7 cells.
20141446 Am80 inhibits surface CXCR4 expression and SDF-1-induced chemotaxis by the acceleration of CXCR4 internalization via activation of conventional PKC
20134207 We hypothesize a presumptive role for CXCL12 and its receptor, CXCR4, in the thymus involution.
20133817 CXCR4 appears to enhance ischemia/reperfusion injury possibly due to enhanced recruitment of inflammatory cells, increased tumor necrosis factor-alpha production, and activation of cell death/apoptotic pathways
20118565 role of SDF-1 and its receptor CXC chemokine receptor 4 (CXCR4; ie, the SDF-1/CXCR4 system) in the pathophysiology of myocardial infarction
20109310 expression up-regulated in polyp tissue of chronic rhinosinusitis
20102637 Chondrosarcoma cell invasion is increased by hypoxia induced expression of CXCR4 and MMP1 and is mediated by HIF-1a and ERK.
20084476 The interaction of SDF-1alpha and CXCR4 plays an important role in pulmonary cellular infiltration during differentiation syndrome
20071457 There was a high expression of CXCR4 in ileal carcinoid biopsies. Targeting of HIFs and/or the CXCR4 signalling pathway may offer new therapeutic strategies for carcinoid tumour disease.
20068066 SDF-1 binding receptors CXCR4 & CXCR7 are differently regulated in rhabdomyosarcom (RMS)cells; upregulation of CXCR4 & downregulation of CXCR7 by PAX3-FKHR or hypoxia may give SDF-1 an advantage to engage CXCR4 receptor, thus increasing RMS motility
20067991 SDF-1alpha/CXCR4 axis is a novel upstream pathway of FASN expression and is associated with mediating its prosurvival effect.
20053635 CXCR4 stimulation increases MCF7 cell attachment
20051874 When CD4 T cells express CXCR4 coreceptors, R5 virions are more fit for replication than X4 virions; limited surface expression of CXCR4 on cell targets could contribute to the preponderance of R5 viruses.
20051874 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
20048153 These studies reveal that site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases resulting in both positive and negative modulation of CXCR4 signaling.
20041213 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
20036848 Targeted inhibition of CXCR4 could be introduced to control metastasis development in uveal melanoma metastases.
20035824 Studies suggest that CXCR4 inhibition to decrease cell proliferation and to control the leukemic burden may provide a novel therapeutic strategy in patients with advanced FLT3-ITD-positive AML.
20028517 data show that regulation of CXCR4 surface expression in neuroblastoma cells can occur independently of SDF-1 contribution arguing against an autocrine mechanism
20025867 Bone marrow stem cell migrate to vascular endothelial cells via SDF-1alpha/CXCR4 signaling.
20023696 Expression of CXCR4 is downregulated in clinical samples of Kaposi sarcoma.
20018238 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
20015684 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
20007689 Identify CXCR4 as a key player in the endothelial cell response to acidic pH and indicate a role for HIF-1alpha.
20007245 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
19956569 Recruitment of beta-Arrestin 2, but not beta-Arrestin 1, to the active WHIM-mutant receptor is delayed compared to the WT CXCR4 receptor and Grk6 fails to associate with the WHIM-mutant receptor.
19950235 Observational study of gene-disease association. (HuGE Navigator)
19932585 Our results indicate that DNMT1 plays the main role in maintenance of methylation of CXCR4 promoter, while DNMT3B may function as an accessory DNA methyltransferase to modulate CXCR4 expression in AsPC1 cells.
19923906 CXCR4 promotes motility and proliferation of glioma cells.
19921580 Shikonin may also play a role in anti-metastasis via down-regulating the expression of CXCR4 and reducing the CXCL12-induced migratory response in colorectal carcinoma cells.
19913121 Observational study of gene-disease association. (HuGE Navigator)
19912363 CXCR4 plays an important role in tumour angiogenesis of colorectal cancers
19906780 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
19885584 CXCR4 nuclear localization follows binding of its ligand SDF-1 and occurs in metastatic but not primary renal cell carcinoma
19885584 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
19879194 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19859817 These findings implicate the CXCR4-CXCL12 axis in the metastasis of renal cell carcinoma.
19837984 Results describe the interaction between the full-length CXCR4 and SDF-1.
19837465 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
19830694 These results provide a plausible mechanism for EGFRvIII-mediated invasion and establish a functional link between EGFRvIII and CXCR4 signaling pathways.
19825996 Our results suggest that the phenotypic knockout strategy of CXCR4 using a novel recombinant protein TAT/54R/KDEL might be a possible approach for inhibiting relative tumor metastasis mediated by CXCR4/CXCL12 interaction.
19820417 Studies show that CXCR4-induced proliferation is mediated by both AKT and ERK signaling in both murine and human pancreatic cancer cells.
19816596 usage of CCR5 is correlated with relatively high sequence conservation whereas CXCR4-tropic viruses spread over larger regions in sequence space
19816083 BCL-6-transfected breast cancer cell lines expressed significantly higher levels of CXCR4, Itgbeta-3 and FLT-1.
19812382 No association between rs2228014 and risk of CLL was seen. A truncating (W195X) & 2 missense mutations with possible functional consequences (V139I & G335S) were identified among 186 familial cases and 0 in 213 controls sequenced.
19812382 Observational study of gene-disease association. (HuGE Navigator)
19812192 CXCR4-induced T cell adhesion and migration are not affected by loss of SH2 domain containing leukocyte protein of 76 kDa (SLP76) in Jurkat T cells.
19796655 Nuclear localization sequence of CXCR4 was located in amino acids 90-170, which accorded with the results of bioinformatics analysis software.
19784070 Findings indicate that PAUF enhances the metastatic potential of pancreatic cancer cells, at least in part, by upregulating CXCR4 expression.
19774645 Upregulation of CXCR4 is associated with inflammatory bowel disease.
19769961 Results reveal a positive correlation between CXCR4, CCR5, and TLR4 expression in hiv-infected t-lymphocyte subsets.
19765831 The receptor for CXCL12, CXCR4, is strongly expressed on human brain microvessel endothelial cells under standard culture conditions and is downregulated upon binding to CXCL12, after incubation of the monolayers with cytokines and lipopolysaccharide.
19762327 Impaired recruitment of HHT-1 mononuclear cells to the ischaemic heart is due to an altered CXCR4/CD26 balance.
19761697 CXCR4 expression is up-regulated in chronic atrial fibrillation patients with mitral valve disease and is associated with atrial remodelling; these effects are attenuated by renin-angiotensin system blockers.
19735481 that the chemokine receptors CXCR1, 3 and 4 modulate some aspects of ASM function but their importance in asthma is uncertain.
19731977 Our data support the notion that CCR3, CCR7, and CXCR4 are increasingly expressed in tumor cells from PTC and that CXCR4 expression in PTC could be a potential marker for enhanced tumor aggressiveness.
19730683 Observational study of gene-disease association. (HuGE Navigator)
19716197 expression correlates with a favorable prognosis in patients with lung adenocarcinoma
19703720 Adhesion of haematopoietic stem cells to liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4.
19695656 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
19692474 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
19688824 Data show that PGK1 regulates the expression of CXCR4 and beta-catenin at the mRNA and protein levels
19671192 Data show that the use of siRNA against KLF2 led to an upregulation of CXCR4 mRNA.
19665027 Data show that CD74 forms functional complexes with CXCR4 that mediate MIF-specific signaling.
19661992 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
19654311 BCR signaling promotes decrease of CXCR4 and CD62L membrane expression in progressive cases only.
19615279 CXCR4 expression is closely correlated to metastasis of nasopharyngeal carcinoma.
19615218 The expression of CXCR4 was significantly associated with lymphatic metastasis of pancreatic adenocarcinoma.
19605489 analysis of a simian immunodeficiency virus SIVmac239 variant with tropism for CXCR4 in human cells
19593633 Overexpression of CXCR4 is associated with primary tumor of patients with HER-2 negative breast cancer
19588204 High CXCR4 is associated with liver metastasis of colorectal cancer.
19584257 Investigated MMP-1 and CXCR4 expression in normal human mammary fibroblasts (HMF) exposed to soluble breast cancer factors. Results show soluble factors secreted by SUM102 breast cancer cells stim'd the expression of MMP-1 and CXCR4 in HMF.
19580679 Neuropilin-2 in breast cancer has a role in lymph node metastasis, poor prognosis, and regulation of CXCR4 expression
19570110 significant association between expression of CXCR4 and lymph node metastasis, tumor size, UICC stage, tumor histology grade. SDF-1 stimulated proliferation of oral SCC cell and CXCR4 neutralization by monoclonal antibodies decreased proliferation.
19568410 the CXCR4 ligand CXCL12 is expressed by endothelial cells and likely Kupffer cells lining the liver sinusoids of liver metastatic human HEP-G2 hepatoma and HT-29LMM colon cancer
19567784 Investigated CXCR4 expression and activity in breast cancer cell line. Treatment with omega-3 polyunsaturated fatty acids disrupted the lipid raft domains in a manner similar to methyl-beta-cyclodextrin and resulted in a partial displacement of CXCR4.
19563077 Arrest of CXCR4 can inhibit liver metastasis of colon cancer through blocking cell proliferation and migration induced by SDF-1.
19556424 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
19551455 In the human substantia nigra (SN), CXCR4 immunoreactivity was high in dopaminergic neurons. the SN of PD subjects exhibited higher expression of CXCR4 expression and CXCL12 than control subjects.
19550128 Data show that CXCL12/CXCR4 is intensively expressed in esophageal squamous cell carcinoma, and the level of CXCR4 is positively correlated to progression and prognosis of ESCC.
19540208 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
19526283 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
19525448 Our data demonstrate the feasibility of imaging CXCR4 expression in experimental brain tumors.
19523923 SDF-1alpha/CXCR4 axis involves in cyclic stretch -mediated cellular functions in human saphenous vein smooth muscle cells.
19521120 HGF has a direct effect on glioma cell proliferation and invasion. HGF up-regulates SDF-1 and CXCR4 mRNA expression and contributes to cell invasion.
19520808 Wnt5A is a critical mediator of CXCL12-CXCR4 signaling and migration in human and murine T
19513623 The SDF-1/CXCR4 axis played a critical role in the metastasis of human ovarian cancer by increasing the adhesion capability of cancer cells and the activity of MMP-2 and MMP-9 via ERK1/2 signaling pathway.
19513547 CCR7 and CXCR4 expression predicts lymph node status including micrometastasis in gastric cancer.
19497995 The rate of breast cancer-specific mortality was much higher in patients with both high p-CXCR4 expression and low plasma SDF-1 levels
19496172 SDF-1alpha acts through CXCR4 to activate MEK and ERK, which in turn activates IKKalpha/beta and NF-kappaB, resulting in the activations of alphavbeta3 integrins and contributing the migration of human osteosarcoma cells.
19494283 CXCR4 expression can properly separate human centroblasts from centrocytes
19492159 levels of CXCR4-positive endothelial cells are negatively correlated with coronary artery disease severity
19476565 CXCR4, a G-protein-coupled receptor with a unique ligand, CXCL12, may be involved in the pathogenesis for type 1 diabetes.
19473177 Results indicate that an activating mutation of the CXCR4 may not be a common pathogenetic mechanism in GH-producing pituitary tumours and NFPAs.
19473177 Observational study of gene-disease association. (HuGE Navigator)
19472013 Observational study of gene-disease association. (HuGE Navigator)
19460858 AR can utilize the CXCL12/CXCR4 axis through induction of KLF5 expression to promote prostate cancer progression
19457995 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
19449444 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
19438749 This study suggests that up-regulation of cytoplasmic expression of CXCR4 might be one of the molecular mechanisms facilitating lymph node metastasis of invasive micropapillary carcinoma
19433312 The regulation of CXCR4 expression on fibrocytes mediates their influx to the lung in the context of pulmonary fibrosis.
19414793 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
19401538 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
19391039 SDF-1/CXCR4 has a role in the development and progression of myeloma
19379578 Umbilical cord blood-derived stromal cells may play an important role in secreting high levels of SDF-1 and regulating megakaryocyte expression of CXCR4.
19379577 There was a correlation between the chemotactic rate of AC133(+) cells and the expression of CXCR4.
19379572 Rapamycin significantly inhibits the growth of RPMI8226 cells in a dose-and time-dependent manner and induces cell apoptosis by downregulating CXCR4.
19373784 At least one mutated allele of CXCR4 gene is associated with the development of stage III or IV and the induction of lymph-node metastasis of oral cancer disease in Taiwanese.
19373784 Observational study of gene-disease association. (HuGE Navigator)
19366992 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
19352387 CXCR4 in resected pancreatic adenocarinoma may represent a valuable prognostic factor for survival after pancreatectomy.
19351212 There are CXCR4-using strains among HIV-1 clade C strains circulating in India.
19340288 show that the chemokine receptor CXCR4 stimulates the production of the chemokine CCL20 and that CCL20 stimulates the proliferation and adhesion to collagen of various tumor cells
19339953 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
19339951 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
19336886 CXCL12/CXCR4 signaling in glioma cells may be another mechanism for these cells to express plasminogen activator inhibitor-1
19336475 Observational study of gene-disease association. (HuGE Navigator)
19335218 Targeted disruption of the CXCL12/CXCR4 axis inhibits osteolysis in a murine model of myeloma-associated bone loss.
19327121 there was no significant association between CXCR4 gene polymorphism and either hepatocellular carcinoma risk or pathological status
19327121 Observational study of gene-disease association. (HuGE Navigator)
19305148 This is the first report of a spontaneously occurring, functionally active CXCR4 mutation in human cancer cells.
19302975 CXCR4/SDF-1 pathway was critical for TLR9 agonist to enhance the metastasis of human lung cancer cells.
19297481 pairwise competitions were performed between CCR5-tropic (R5) or CXCR4-tropic (X4) virus isolates in peripheral blood mononuclear cells (PBMC)
19272813 Expression is a significant prognostic indicator for poor survival in patients with oral squamous cell carcinoma
19260802 SDF-1alpha/CXCR4 chemoattraction system can be used to efficiently recruit bone marrow stromal cells into SDF-1alpha-releasing 3 dimensional scaffolds in vitro and in vivo.
19252530 Observational study of gene-disease association. (HuGE Navigator)
19240061 Observational study of gene-disease association. (HuGE Navigator)
19232661 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
19228923 High levels of CXCR4 is associated with mantle cell lymphoma.
19212630 HIF-1alpha regulated hypoxia-induced CXCR4 expression in oral squamous cell carcinoma
19200444 C1-C4 region of HIV2 SU glycoprotein impairs utilization of the CCR5 and CXCR4 for viral entry.
19199057 CXCR4-CXCL12 axis can play a role in the progression of endometrial carcinoma and that specific therapies with antagonists of chemokines receptors could be of help in the treatment of metastatic patients.
19196101 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19180188 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
19178925 This study and previous reports showing that CD4 mutants localized to non-raft domains function as HIV-1 receptor indicate that CXCR4 clustering in the raft microdomains, rather than CD4, is the key step for the HIV-1 entry.
19178925 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
19149577 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
19148483 Strong expression of CXCR4 by gastric cancer cells is associated with lymphatic metastasis in patients with gastric cancer, and CXCR4 may play an important role during gastric cancer progression.
19147814 combination therapies that target CXCR4 and MT1-MMP should improve the limitations of the current therapies for metastatic melanoma.
19139298 Robust expression of CXCR4/CXCL12 on inflammatory elements in MS lesions highlights a role of this chemokine/receptor pair in central nervous system inflammation.
19136936 A novel property of the chemokine receptor CXCR4 in inhibiting detachment-induced cell death--anoikis, which is believed to be one of the major blocks in the metastatic spread of various neoplasms.
19134328 The interactions between CXCL9, CXCL10 and CXCL12 expressed in decidua and villi and CXCR3, CXCR4 expressed in CD(56)(+) decidua NK cells may influence the CD(56)(+)NK cell recruitment at the maternal-fetal interface.
19125297 This study examined CXCR4 mRNA expression in peripheral blood cells and malondialdehyde (MDA) in plasma from blood donors and breast cancer patients.
19116316 AIP4 can interact directly with CXCR4 via a novel noncanonical WW domain-mediated interaction involving serine residues 324 and 325 within the carboxy-terminal tail of CXCR4.
19115008 Observational study of gene-disease association. (HuGE Navigator)
19113880 observations suggest that increased cell surface expression of CXCR4 on CD34(+) cells improved the engraftment of human umbilical cord blood cells into bone marrow through enhanced homing activity.
19107931 CXCR4 has a role in VEGF expression and poor survival in soft-tissue sarcoma
19082444 positive CXCL12 expression was related to a greater degree to tumor development in patients with esophageal squamous cell carcinoma, compared with CXCR4 expression
19074885 Observational study of gene-disease association. (HuGE Navigator)
19066282 Results suggest that activated moesin promotes F-actin redistribution and CD4-CXCR4 clustering and is also required for efficient X4-tropic HIV-1 infection in permissive lymphocytes.
19066282 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
19064997 CXCR4 as a bona fide signaling receptor for TFF2 and suggest a mechanism through which TFF2 may modulate immune and tumorigenic responses in vivo.
19057930 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
19055831 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
19053768 analysis of how isothioureas block function of the chemokine receptor CXCR4
19047650 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
19042019 groups: patients overexpressing 2 or 3 factors had a significantly shorter OS (p=0.015). CXCR4, VLA-4 and FAK are new phenotypic markers which could be helpful to establish risk-stratified therapeutic strategies
19035451 PaCa-derived CXCL8 and fibroblast-derived CXCL12 and corresponding receptors CXCR2 and CXCR4 cooperatively induce angiogenesis in vitro by promoting HUVEC proliferation, invasion, and tube formation
19025611 a role for NO in stimulating cytoplasmic CXCR4 expression in vitro; cytoplasmic CXCR4 expression may serve as a significant prognostic factor for long-term survival in breast cancer
19020832 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
19020816 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
19020745 Results suggest that CXCR4 expression, histological patterns, and metastatic potential are closely related in adenoid cystic carcinoma.
19020538 In early stage MDS, compared with normal hematopoiesis and late stage MDS, T(regs) are dysfunctional and their BM homing through the CXCL12/CXCR4 axis is seriously impaired as a result of CXCR4 downregulation.
19019622 Down-regulation of CXCR4 expression by tamoxifen is associated with DNA methyltransferase 3B up-regulation in MCF-7 breast cancer cells.
19017998 infiltrated neutrophils from patients with chronic inflammatory lung diseases and rheumatoid arthritis highly express CCR1, CCR2, CCR3, CCR5, CXCR3, and CXCR4
19008040 results implicate an important role for the CXCR4 signaling mechanism in glioma CSC biology and point to the therapeutic potential of targeting this pathway in patients with glioblastoma multiforme
19002187 CXCR4 could modulate the canonical Wnt pathway in pancreatic cancer progression.
18991615 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
18977142 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
18976975 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
18976975 HIV-1 (NL4-3 derived NLENG1 (enhanced green fluorescent protein, (EGFP) gene linked with internal ribosome entry site between env and nef genes)) cell-to-cell transmission from lymphocytes to astrocytes requires CXCR4
18976462 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
18958626 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
18957686 pO(2) must be considered a critical variable in conducting and interpreting studies of CXCR4 expression and regulation in leukemias
18954561 CXCR4 and CXCL12 may play an important role in the metastasis of HCC by promoting the migration of tumor cells.
18949410 In gastric cancer, CXCL12/ CXCR4 axis seems to be more strongly associated with lymphatic or hematogenous metastasis than the establishment of peritoneal deposits.
18948617 IGF-1 transgene expression induces massive stem cell mobilization via SDF-1alpha signaling and culminates in extensive angiomyogenesis in the infarcted heart.
18930512 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
18925934 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
18923649 CXCR4 and CCR5 spontaneously form heterodimers and ligand-binding to CXCR4 or CCR5 causes different conformational changes affecting heterodimerization
18851783 CXCR4/SDF-1 participates in tumor invasiveness and metastasis in cervical cancer through regulating the adhesion ability by activating the MAPK signaling transduction pathway and promoting secretion of MMP-2.
18850076 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
18836306 CXCR4/SDF-1 interaction blockade in prostate cancer cells by hTERT promoter induces CXCR4 knockdown and prevents metastasis
18834145 Sequential tyrosine sulfation of CXCR4 by tyrosylprotein sulfotransferases is reported.
18829537 Slits are negative regulators of Sdf1 and Cxcr4 in breast cancer cells.
18820725 CCR5/CXCR4 chimeric receptors have roles in immunological failure in HIV-infected children
18815295 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
18812968 High-grade gliomas robustly express CXCR4 and demonstrate a correlative relationship between expression levels and the magnetic resonance imaging (MRI) scan finding of a more extensive disease process in the brain.
18808680 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
18807177 This study suggests a pivotal role of PI3 K, MAPK and mTOR pathways, via tuberin, in post-transcriptional control of CXCR4.
18803056 CXCR4 is associated with the progression of colorectal carcinoma. High CXCR4 expression is associated with metastasis.
18799424 CXCR4 bridged the SDF-1 dimer interface so that sulfotyrosines sTyr7 and sTyr12 of CXCR4 occupied positively charged clefts on opposing chemokine subunits.
18798091 Structural characteristics of the coding section and the intron of the human chemokine CXC receptor 4 are reported.
18788913 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
18788547 SDF-1alpha accelerated the proliferation and the migration of dental pulp cells which expressed CXCR4.
18784079 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
18781098 the CXCL12/CXCR4 system may play a role in tumor cell spread to lymph nodes and also in neoplastic development.
18775311 HIV utilizes the Galphai-dependent signaling from the chemokine coreceptor CXCR4 to activate a cellular actin-depolymerizing factor, cofilin, to overcome the static cortical actin restriction in resting CD4 T cells.
18775311 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
18769446 Our study defines a new role for the SDF-1/CXCR4 axis in the regulation of leukemic cell survival and differentiation
18765807 Binding to CXCR4 induces cAMP-dependent protein kinase A (PKA) signaling, which in turn inhibits TLR2-mediated proinflammatory and antimicrobial responses to the pathogen
18760839 These results show a new function of HIV-1 Tat, its ability to regulate CXCR4 expression via PKCzeta.
18760839 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
18760838 S1P(1) acts as an inhibitor of CXCR4-dependent migration of hematopoietic cells to sites of SDF-1 production.
18753930 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
18707241 Disruption of the proline-rich region of Nef inhibits CXCR4-mediated T-cell migration to SDF-1 alpha.
18707241 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
18701133 The association between aberrant expression of CXCR4 in the nucleus of non-small cell lung cancer and metastasis to lymph nodes points toward a potential tumor metastasis promoting function of nuclear CXCR4.
18698020 CXCR4 and SDF1 are overexpressed in human pituitary adenomas
18696160 High CXCR4 expression is associated with extrathyroidal extension, angiolymphatic invasion, and lymph node metastasis in papillary thyroid carcinoma.
18692524 CXCL12 is also produced by human thymic dendritic cells (DCs), most of which express CXCR4 receptor
18653785 Blocking CXCR7 can be useful for therapeutic interference with CXCR4-mediated activation of integrins.
18636124 Observational study of gene-disease association. (HuGE Navigator)
18634924 may play a role in the recruitment of CXCR4-positive dental pulp cells toward damaged sites
18632580 simultaneous expression and cooperation between CCR5 and CXCR4 are required for chemokine-induced T cell costimulation at the immunological synapse
18624931 downregulation induces anti-proliferative and anti-invasive effects in oral squamous cell carcinoma
18624812 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
18614865 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
18599607 Neuronal and endothelial cells exposed to VEGF up-regulated the expression of SDF-1alpha. CXCR4-positive tumor cells migrated toward a SDF-1alpha gradient in vitro, whereas inhibition of CXCR4 expression decreased their migration
18593989 CXCR4 and c-Met are widely expressed in rhabdomyosarcoma and, at higher levels, in isolated marrow-infiltrating tumor cells
18577234 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
18570923 Data show that the COOH-terminal fragment of procollagen type I (C3) induces expression of VEGFA and CXCR4 in MDA MB 231 breast cancer cells.
18568019 Data indicate that megakaryopoiesis is controlled by a cascade pathway, in which PLZF suppresses miR-146a transcription and thereby activates CXCR4 translation.
18562079 Coculture with human stromal cells induced expression of CD34 and CXCR4 on CB Lin(-)CD34(-) cells.
18556411 Using a 4-color flow cytometric protocol, an increased number of CXCR4 positive hematopoietic circulating progenitor cells (HCPCs) was detected in systemic sclerosis patients compared with healthy subjects.
18524826 dendritic cells transmit CXCR4-tropic HIV-1 much more efficiently than CCR5 strains
18519809 VLA-4, CX3CR1, and CXCR4, involved in T-cell homing, had increased expression in ITP patients
18511598 abnormal methylation of the CXCR4 promoter is a mechanism contributing to constitutive migration of CD34(+) cells in primary myelofibrosis
18502034 Breast cancer metastasis suppressor 1 inhibits SDF-1alpha-induced migration of non-small cell lung cancer by decreasing CXCR4 expression.
18500445 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
18487224 CXCL12 enhances Laryngeal and hypopharyngeal squamous cell carcinoma cell invasiont through paracrine-activated CXCR4, triggering MMP-13 upregulation.
18480460 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
18468560 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
18461161 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18448868 the CXCR4/SDF-1 axis interacts with VLA-4 in regulating migration and adhesion of Waldenstrom macroglobulinemia cells in the bone marrow microenvironment
18443596 Expression of nuclear CXCR4 predicts lymph node (LN) metastasis in colorectal cancer (CRC).
18438604 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
18431597 The PSA-CXCR4 retrovirus vector may be a potential choice in gene therapy for androgen-responsive prostate cancer.
18416455 Inhibition of CXCR4 activity with AMD3100 decreases invasion of human colorectal cancer cells in vitro.
18377645 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
18373506 In node-negative breast cancers CXCR4 membrane expression is prognostic and probably plays a key role in vascular invasion by cancer cells and a role in lymphatic invasion.
18365549 Overexpressions of CXCR4 ligand receptor in sinusoidal endothelial cells in hepatocellular carcinoma suggest that the CXCR4 ligand receptor pathway plays a possible role in HCC progression through neoangiogenesis
18357387 SDF-1alpha and CXCR4 expressions are possible markers of highly-invasive SCC and regulated by epithelial-mesenchymal transition.
18353956 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
18339870 Cell surface, total protein, and mRNA levels of CXCR4, principal signaling receptor for SDF1, were significantly decreased in Dll4-transduced endothelial cells, attributable to a significant reduction of CXCR4 promoter activity.
18339860 YY1 and VEGF/CXCR4 seem to intervene in the pathogenesis of the malignant phenotype of osteosarcoma by acting on cell invasiveness and metastasis growth.
18337451 Lipid raft-disrupting agents inhibited raft-associated CXCL12/CXCR4 transactivation of the HER2 and cellular invasion in prostate cancer cells.
18334485 expression of CXCR4 by human mesenchymal stem cells (hMSCs) regulates hMSC adhesion to endothelial cells
18292939 CHK is capable of inhibiting the CXCL12-CXCR4 pathway in neuroblastoma.
18288973 in cultured human breast cancer cells HIV-1 induced apoptosis is mediated via CXCR4 in breast cancer cells that exhibit conformational heterogeneity in comparison with CXCR4 in T-cells
18288973 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
18286257 Reduced expression of CXCR4 and CD34/CXCR4-positive cells was also observed in diabetic patients correlated with levels of progenitor cells
18281050 CXCR4, expressed on infiltrating lymphocytes, and CXCL12, expressed on stromal cells, is involved in the recruitment of lymphocytes within the arterial wall in abdominal aortic aneurysms
18274673 role for GRK3 in regulating CXCR4 attenuation and have provided a mechanistic link between the GRK3 pathway and the CXCR4-related WHIM(WT) disorder.
18267010 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
18242797 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
18239145 REVIEW: molecular mechanism by which neutrophils accumulate at the advanced plaques
18235009 CXCR4 and CCR7 provide directional migration of uveal melanoma cells toward the liver, the most common site for the formation of uveal melanoma metastases.
18234887 Constitutive deletion of Cxcr4 specifically in interneurons alters the regional distribution of interneurons within the cortex and leads to interneuron laminar positioning defects in the transgenic postnatal cortex.
18219852 Establishment of a CXCR4 expressing human gastric cancer cell line transplantable into nude mice seems to be important in discussing the possibility of an in vivo model of treatment with AMD 3100 in the in vivo system
18210030 Observational study of gene-disease association. (HuGE Navigator)
18206727 Altered SDF-1/CXCR4 axis in patients with primary myelofibrosis and in the Gata1 low mouse model of the disease
18201276 the pattern of chemokine receptor CXCR4 expression in patients with metastatic prostate cancer.
18200497 With delta opioid receptor, forms heterodimeric complexes that are dynamically regulated by the ligands.
18197116 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
18190699 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
18187620 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
18187620 HIV-1 (NL4-3 derived NLENG1 (enhanced green fluorescent protein, (EGFP) gene linked with internal ribosome entry site between env and nef genes)) cell-to-cell transmission from lymphocytes to astrocytes requires CXCR4
18182005 Data show that an N-terminal deletion mutant of CD63 blocks entry of CXCR4-using, T-cell tropic human immunodeficiency virus type 1 (X4 HIV-1) by suppressing CXCR4 surface expression.
18175225 Increased CXCR4 is associated with angiogenesis in pancreatic cancer.
18160142 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
18155192 Thus, plectin appears to interact with CXCR4 and plays an important role in CXCR4 signaling and trafficking and HIV-1 infection.
18097955 high APN enzyme activity may antagonize the cellular properties regulated by the CXCR4/SDF-1alpha system in embryonic kidney cells.
18090388 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
18089812 CXCR4 targeting is a novel potential strategy in the treatment of human anaplastic thyroid cancer.
18087217 LMP1 upregulates CXCR4 expression and induces CXCR4 moving into the cell nucleus in nasopharyngeal carcinoma cells.
18083706 studies demonstrate that KLF2 is required for smooth muscle cell migration and elucidate a novel mechanism involving communication between PDGF and KLF2 in vascular maturation
18081034 CXCR4 is not only involved in LPS binding but is also responsible for triggering signalling
18040858 Review highlights the differential expression of CXCR4 and CXCL12 and their importance for the temporal regulation of neuronal migration and circuit formation during development and possibly in adult neurogenesis and repair.
18037996 BSDL plays a role in optimal platelet activation and thrombus formation by interacting with CXCR4 on platelets.
18036244 HIV-1 chimeras were able to infect U373MAGI-CD4+-CCR5+ but not U373MAGI-CD4+-CXCR4+ cell line, suggesting CCR5 coreceptor utilization and R5 phenotypes.
18036244 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
17991743 Data show CXCR4 was co-immunoprecipitated with cyclophilin and a Ligand stimulation of CXCR4 induced CyPA phosphorylation and nuclear translocation.
17977968 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
17964871 G-CSF treatment induced reduced expression of CXCR4, VLA-4 and VEGFR-1 in patients with liver failure.
17959679 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
17947541 CXCR4 glycan inhibits CD4-independent X4 virus infection.
17947541 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
17947233 the AIP4.arrestin-2 complex functions on endosomes to regulate sorting of CXCR4 into the degradative pathway
17933721 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
17933717 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
17925864 CXCR4 strongly promotes neuroblastoma primary tumour and metastatic growth, but not invasion
17916907 bone marrow-derived-SDF-1alpha enhances the invasiveness of lung cancer cells by increasing MMP-9 expression through the CXCR4/ERK/NF-kappaB signal transduction pathway
17895991 Data indicate that the evolution of CXCR4 (X4)-using viruses is a multi-step, temporally structured process and that the thymus may play an important role in the evolution/amplification of coreceptor variants.
17894415 Immunolocalization of IL-7, IL-7Ralpha, SDF-1alpha, and CXCR4 resulted in a diffuse but specific labeling. RT-PCR analysis confirmed the expression of the above-mentioned transcripts.
17893878 Overexpression of SDF-1alpha/CXCR4 is associated with enhanced peritoneal metastasis of epithelial ovarian carcinoma
17889832 Data support the conclusion that miRNA against CXCR4 can serve as an alterative means of therapy to lower CXCR4 expression and to block the invasion and metastasis of breast cancer cells.
17888880 The CXCR4 binding assay conditions and radioligand binding assay are highly valuable to identify and design better HIV inhibitors for HIV dementia.
17888880 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
17881971 The level of CXCR4 expression correlates with the degree of malignancy of human gliomas and may contribute to their rapid growth.
17875700 Hypoxia is associated with up-regulation of CXCR4 expression in human normal and malignant B cells, through both transcriptional and posttranslational mechanisms.
17846797 DPPIV and SDF-1alpha/CXCR4 play crucial roles in regulating the migratory potential of HPMCs, which may be involved in the re-epithelialization of denuded basement membrane at the site of peritoneal injury.
17768666 the involvement of the bone marrow microenvironment and CXCR4/SDF1alpha signaling in metastasis of Rhabdomyosarcoma.
17765649 Aphanizomenon flos water extract contains a novel ligand for CD62L. It modulates CXCR4 expression on CD34+ bone marrow cells in vitro and triggers stem cell mobilization in vivo.
17763975 High expression of nuclear CXCR4 was significantly correlated with lymph node metastasis in breast cancer.
17715399 This study provides evidence for a novel role for NPM as a negative regulator of CXCR4 signaling induced by CXCL12 that may be relevant to the biology of acute myelogenous leukemia.
17715128 analysis of allosteric inhibition by CCR2/CXCR4 heterodimers
17706641 CXCR4 contributes to renal carcinoma cells (RCC) dissemination and may provide a novel link between CXCL12 expression and integrin beta1 triggered RCC adhesion to the vascular wall and subendothelial matrix components
17687643 prolonged Akt activation is an important signaling pathway for breast cancer cells expressing CXCR4 and is necessary for CXCL12-dependent cell migration
17676665 Proteomic analysis was performed of the cellular responses induced in uninfected cells by cell-expressed X4 HIV-1 envelope.
17650669 G-CSF induces hematopoietic stem cell mobilization by decreasing bone marrow SDF-1 and down-regulating CXCR4 expression.
17641542 CXCR4 contributed to lymphatic involvement and nodal metastasis in colorectal cancer.
17640743 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
17634424 These results suggested that, in cases of oral squamous cell carcinoma, the paracrine SDF-1/CXCR4 system potentiates lymph node metastasis, but distant metastasis might require the autocrine SDF-1/CXCR4 system.
17620369 Data suggest that increased expression of CXCR4 associated with HIV binding and entry coupled with decreased innate antiviral factors may render the tonsil a potential site for oral transmission.
17606439 the SDF-1/CXCR4 axis plays an important role in the regulation of motility of Flk1+ MSC
17596666 Observational study of gene-disease association. (HuGE Navigator)
17596666 RANTES, MCP-1, CCR2, CCR5, CXCR1 and CXCR4 gene polymorphisms do not have a role in progression of hepatitis B virus infection
17594938 CXCR4 expression in human microvascular endothelial cells and human melanoma cells is enhanced by hypoxia
17582634 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
17574038 High CXCR4 overexpression had a significant impact on disease-free survival in HER-2 negative breast cancer patients and may help identify a subset of HER-2 negative breast cancers that have a more aggressive biological behavior.
17562613 by down-regulating neutrophil CXCR4 expression and attenuating neutrophil responsiveness to SDF-1, lipopolysaccharide can mobilize neutrophils from bone marrow to the peripheral blood through reducing neutrophil retention in bone marrow
17559806 CXCR4/CXCL12 signaling axis can induce angiogenesis and progression of tumors by increasing expression of vascular endothelial growth factor through the activation of PI3K/Akt pathway
17545018 CCL20 and CXCR4 expressions are markedly down-regulated in epidermal condyloma acuminatum lesions.
17521613 When CXCR4 expression was decreased with siRNA, HRMECs were less invasive and also resulted in markedly diminished vascular networks on Matrigel as compared to the controls.
17510563 The CXCL12 ligand with its exclusive receptor CXCR4 has a pivotal role in the directional migration of cancer cells during the metastatic process. [REVIEW}
17507486 Results describe the evolution of human immunodeficiency virus type 1 (HIV-1) envelope function during the process of coreceptor switching from CCR5 to CXCR4.
17507486 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
17507467 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
17504381 Primary cervical adenocarcinoma cells expressing CXCR4 are significantly more likely to metastasize to pelvic lymph nodes.
17488655 complex interaction between signaling from the CXCR4 receptor on acute lymphoblastic leukemia cells with those initiated by IL-7 & IL-3, suggesting CXCL12 may facilitate ALL proliferation by enhancing cytokine-signaling pathways in responsive cases
17476338 Short-term exposure of MSCs to 1% oxygen increased expression of the chemokine receptors CX3CR1and CXCR4, both as mRNA and as protein
17461449 These results indicated that the activation of CXCR4 and its signaling pathways (MEK1/2 and Akt) are essential for CXCL12-induced cholangiocarcinoma cell invasion.
17459055 CXCR4 expression is an important prognostic factor in ovarian carcinoma.
17457084 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
17456315 The levels of CXCR-4 expression were closely related to the tumor differentiation in hepatocellular carcinoma.
17435771 By activating CXCR4, macrophage migration inhibitory factordisplays chemokine-like functions and acts as a major regulator of inflammatory cell recruitment and atherogenesis.
17411375 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
17379424 Beta-catenin has a significant role in pancreatic cancer progression through interactions with CXCR4.
17355795 CXCR4 overexpression indicates a higher lymph node metastasis potential of cervical adenocarcinoma.
17350297 Reduced expression of CXCR4 by CD34+ cells is a characteristic of myelofibrosis with myeloid metaplasia which is associated with the constitutive mobilization of CD34+ cells and occurs in patients with advanced forms of the disease
17346946 Stimulation of two receptors together, using gp120, a component of HIV enhanced cell adhesion greater than stimulation of CD4 or CXCR4 individually. (gp120)
17346946 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
17331556 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
17329448 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
17328838 CXCR4-positive pancreatic cells express markers of pancreatic endocrine progenitors (neurogenin-3, nestin) and markers of pluripotent stem cells (Oct-4, Nanog, ABCG2, CD133, CD117).
17328229 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
17327270 MIIA plays a role in CXCR4 endocytosis, which involves its dynamic association with beta-arrestin and highlights the role of endogenous MIIA as a regulator of CXCR4 internalization and, therefore, the onset of SDF-1alpha signaling.
17292399 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
17262717 In this study, interleukin 18 (IL-18) levels were higher during early HIV infection, and IL-18 levels predicted reduced CXCR4 HIV-1 coreceptor expression and diminished interferon gamma levels.
17253948 CXCR4 overexpression for improved human adipose tissue stromal cell motility, retention, and proliferation could be beneficial for in vivo navigation and expansion of stem cells.
17251291 mutant receptor (CXCR3[K300A, S304E]) showed markedly enhanced HIV coreceptor function compared to the wild-type receptor (CXCR3[WT])
17202224 SF162 has a single pathway for acquiring CXCR4 use
17202224 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
17201668 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
17198877 curcumin induced downregulation of CXCR4 protein in Follicular Lymphoma cell lines
17188679 Pathway analysis also implicated a role for chemokines and their receptors, specifically CXCR4 and CCR3, in AD.
17187670 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
17176471 Strong CXCR4 expression reveals a poorer long-term prognosis following curative esophagectomy in two predominant histologic types of esophageal carcinoma--squamous cell and adenocarcinoma.
17151939 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
17144914 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
17136117 Isolation from cord blood a population of human cells that are similar to murine bone marrow-derived cells containing CXCR4.
17130833 suggest a mechanism for elevated CXCR4 expression and metastasis of breast cancers with p53 mutations or isoform expression
17121788 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
17119115 CXCR4 is differentially expressed at high levels in the peripheral blood and is down-regulated in the bone marrow in response to high levels of SDF-1.
17082613 CXCR4/CXCL12 interactions may play a role in the accumulation of CXCR4-expressing T cells and a subset of CD25high regulatory T cells within non-small cell lung cancer (NSCLC)tissue.
17075975 CXCR4 expression in colorectal liver metastases suggests it is a predictive factor. CCL20 and receptor CCR6 expression in hepatocellular carcinomas indicates a role of a CCL20/CCR6 ligand-receptor pair in liver carcinogenesis and progression.
17070589 This is the first demonstration of CXCR4 expression in VHL disease-associated retinal hemangioblastomas
17056591 Galpha13-Rho signaling axis is required for SDF-1-induced migration through CXCR4
17041228 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
17038674 The SDF-1/CXCR4 axis plays a critical role in regulating initial vessel formation, and may function as a morphogen during human embryonic vascular development.
17032700 Significantly higher CXCR4 expression is associated with lymph node metastasis in human cervical cancer
17023512 Nitric oxide(NO) pathway can modulate CXCR4 expression in human CD34(+) cells and suggests that NO may play a critical role in the trafficking of hematopoietic progenitors.
17011204 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
17010165 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
16990599 Tax expression correlated with activation of the SDF-1/CXCR4 axis
16987062 CD4, complement receptors, and CXCR4 chemokine receptors are required for complement mediated antibody dependent enhanced entry of HIV into MT2 cells
16978607 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
16969502 expression of AR down-regulates the migratory responses of human prostate cancer cells via CXCR4 and CCR1
16966601 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
16948905 SDF-1 and CXCR4 play an important role in gestation and they are also important in maternofetal immune tolerance during pregnancy.
16948134 CXCR4 is up-regulated in the skin of patients with early systemic sclerosis.
16946301 Expression of the WHIM-type C-terminal-truncated hyperfunctional CXCR4 does not itself cause apoptosis but retards leukocyte release from bone marrow where they senesce.
16943240 In this review, we consider the pathological nature and characteristics of the CXCL12/CXCR4 pathway in the tumor microenvironment. Strategies for therapeutically targeting the CXCL12/CXCR4 axis also are discussed.
16942785 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
16934308 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
16929176 Preferential role of in cytotoxic T lymphocyte migration toward melanoma cells.
16929169 mechanisms involved in hypoxia-induced metastasis and hypoxia-mediated chemokine receptor CXCR4 expression
16928758 Here, we report that Nef downregulates the second major HIV-1 coreceptor, CXCR4, from the surfaces of HIV-infected primary CD4 T lymphocytes with efficiencies comparable to those of the natural CXCR4 ligand, stromal cell-derived factor-1 alpha
16928758 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
16919488 SDF-1alpha stimulates the physical association of CXCR4 and the T cell receptor (TCR) and utilizes the ZAP-70 binding ITAM domains of the TCR for signal transduction
16888620 CISK plays an important role in specifically attenuating ubiquitin-dependent degradation of CXCR4, and provide a mechanistic link between the PI 3-kinase pathway and CXCR4 stability.
16886061 HIV-infected cells can induce autophagy in bystander CD4+ T lymphocytes through contact of Env with CXCR4.
16886061 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
16886053 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
16877302 gp120IIIB toxicity and signaling do not require CXCR4 internalization in SH-SY5Y cells
16863915 CXCR4 may influence the immune system under physiologic and pathologic conditions through negative regulation of MHC class II expression, possibly through PKA and SRC kinase.
16855325 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
16841089 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
16836911 The expression of CXCR4 was significantly correlated with the clinicopathological features and tumor proliferation in oral squamous cell carcinoma.
16823836 Adenosine increases cell-surface CXCR4 protein, which enables the carcinoma cells to migrate toward CXCL12.
16802356 Expression of CXCR4 was significantly reduced in all systemic lupus erythematosus (SLE) subsets compared with normal.
16784459 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
16756955 ligand-dependent degradation and lower HIF-1alpha levels may be potential causes of lowered levels of CXCR4 in the lymph nodes compared to the primary tumors.
16756721 binding of CXCL12 to its receptor leads to enhanced expression of alpha5 and beta3 integrins
16740704 CXCR4-DeltaCTD-transduced MCF-7 cells (MCF-7/CXCR4-DeltaCTD cells) exhibit a higher growth rate and altered morphology, potentially indicating an epithelial-to-mesenchymal transition.
16702010 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
16697675 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
16685256 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
16679918 CXCR4 expression significantly correlated with known prognostic factors at relapse in childhood acute lymphoblastic leukemia.
16675573 In colorectal cancer, CXCR4 triggers stimulation of clonogenic growth, induction of VEGF release, and ICAM-1 up-regulation.
16672549 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
16638848 Findings indicate that CXCR4 is expressed and active in human melanoma metastases.
16631222 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
16618732 CXCR4 function is subject to complex and potentially tightly controlled regulation in breast cancer cells via differential G protein-receptor complex formation, and this regulation may play a role in the transition from nonmetastatic to malignant tumors.
16585856 The specific 30-bp deletion of the Epstein-Barr virus (EBV)-derived latent membrane protein-1 gene has been suggested to be associated with the pathogenesis of nasopharyngeal carcinoma (NPC).
16553776 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
16528367 Rsults suggested that CXCR4 expression was associated with metastatic progression.
16524887 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
16494621 The SDF-1/CXCR4 axis promotes hematopoietic stem/progenitor cell proliferation in contact with mesenchymal stem cells.
16494043 CXCR4 and CCR7 are highly expressed in laryngeal carcinoma. Expression was associated with tumor grade, clinical stage and neck lymph node metastasis.
16489019 Results strongly suggest that the CXCR4/CXC12 axis plays an important role in the development of peritoneal carcinomatosis from gastric carcinoma.
16467205 in hematopoietic cells stimulated via CXCR4, Lyn kinase is a positive regulator of cell movement while negatively regulating adhesion to stromal cells by inhibiting the ICAM-1-binding activity of beta(2) integrins
16437164 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
16400660 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
16386774 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
16378977 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
16375941 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
16368946 CXCR4 may have a role in early metastatic spread because its expression was associated with micrometastases to both the lymph nodes and bone marrow.
16327980 findings suggest that CXCR4 might be involved in the lymph-node metastasis of oral squamous cell carcinoma
16322285 Overexpression of CXCR4 is associated with the metastatic potential of human non-small cell lung cancer
16314403 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
16306611 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
16284526 Observational study of gene-disease association. (HuGE Navigator)
16284526 Comprehensive mutation analysis of the CXCR4 gene confirmed a high degree of genetic conservation within the coding region of this ancient sub-Saharan African population belonging to the Xhosa ethnic group of South Africa.
16230077 CXCR4 expression mediates organ-specific metastasis of pancreatic cancer cells.
16227248 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
16204649 These findings demonstrated a correlation between the enhanced susceptibility of activated T cells to HIV-1 fusion and accumulation of ubiquitinated 62-64 kDa CXCR4 species, which preferentially associated with CD4.
16188969 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
16179731 in contrast to the CD34+ progenitors, the lineage-committed hematopoietic progenitor cells express high levels of the HIV-1 co-receptors, CXCR4 and CCR5
16179731 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
16172123 CXCR4 is trans activated by IGF1R in human breast cancer epithelial cells
16114056 CXCL12/CXCR4 axis is expressed in prostate cancer bone metastasis and exogenous CXCL12 induced MMP-9 expression.
16084492 CXCR4 may contribute to the high level of VEGF produced by malignant glioma cells
16047221 Human glomerular endothelial cells express CXCR4 mRNA and protein.
16047221 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
16044003 These data suggest that CXCR4 overexpression during the course of the disease in some patients could favor the emergence of X4 strains.
16005638 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
15998835 RGS16 is a negative regulator of CXCR4 signaling in megakaryocytes
15995960 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
15995960 The presence of CXCR4 variants before initiation of highly active antiretroviral therapy was not independently associated with a poorer outcome of therapy.
15992849 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
15972662 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
15890935 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
15880586 Amino acid substitutions in the Cxcr4 is associated with the pathogenesis of medulloblastomas
15867478 High expressions of CXCR4 is associated with differentiated and intestinal-type gastric cancers
15857508 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
15844659 prostate cancers may be influenced by the CXCL12:CXCR4 pathway during metastasis
15843590 In an organotypic melanoma culture, cytotoxic T cells (CTL) mediated by chemokine receptor CXCR4 expressed by the CTL migrate from the top layer through a collagen/fibroblast separating layer toward the tumor cells, resulting in tumor cell apoptosis.
15831676 SDF-1alpha induces a CXCR4-dependent migration of HeLa cells
15814634 Data suggest that CXCR4 could be useful as a prognostic factor and as a predictor of potential metastatic development in osteosarcoma.
15806155 activation of integrins and CXCR4 chemokine receptors co-operate in mediating adhesion and survival signals from the tumor microenvironment to SCLC cells
15805285 CHK down-regulates CXCR4 through the YY1 transcription factor, leading to decreased CXCR4-mediated breast cancer cell motility and migration.
15802268 EGF and hypoxia induce CXCR4 in non-small cell lung cancer, a process regulated by the PI3-kinase/PTEN/AKT/mTOR signaling pathway and activation of HIF-1alpha
15794931 binding by stromal cell-derived factor-1 promotes chemotactic recruitment, development and survival of human osteoclasts
15787642 Observational study of genotype prevalence. (HuGE Navigator)
15784966 Quantitative RT-PCR analysis showed down-regulation by 3.86 and 1.9 for IL-6 and CXCR4 genes, respectively by recombinant erythropoietin
15784911 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
15781337 propose that decreased internalization of WHIM-associated mutated CXCR4 leads to enhancement of signaling in response to SDF1, providing biochemical basis for the autosomal dominant abnormalities of cell trafficking and function
15753377 Epigenetic up-regulation of C-X-C chemokine receptor type 4 expression is associated with melanoma
15748209 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
15737629 Finally, we conclude that the up-regulation of CCR5 and CXCR4 can at least partially contribute to the down-regulation of transfactor YY1 which is p38 MAPK pathway-dependent and this up-regulation has little relationship with MTB and HIV co-infection.
15737612 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
15719026 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
15710459 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
15705741 Laminar shear stress(LSS)-dependent CXC chemokine receptor 4 (CXCR4) down-regulation may contribute to atheroprotection by favoring the integrity of the endothelial barrier
15701832 Increased CXCR4 Receptor expression is associted with osteosarcoma tumor progression
15687242 lack of CXCR4 expression on plasma-cell precursors is not a limiting factor for plasma-cell homing and that the expression of CXCR3 on memory B cells
15681827 decreased circulating CD26 levels in arthritis may influence CD26-mediated regulation of the chemotactic SDF-1/CXCR4 axis
15670831 CXCR4 could exert local control of TLR4 and suggest the possibility of new therapeutic approaches to suppression of TLR4 function
15662133 study provides first evidence for epigenetic regulation of CXCR4 in human cancers, providing new insights into the role of CXCR4/CXCL12 interactions in tumor progression
15650174 used preferentially by R5X4 HIV-1 isolates for infection of primary lymphocytes
15632118 examination of ligand-induced conformational changes in CXCR4 homo- and heterodimers by bioluminescence resonance energy transfer
15615703 The N-terminal part of the 1st intracellular loop (ICL) is needed to activate Jak2 after SDF-1alpha binding to CXCR4, leading to phosphorylation of only one cytoplasmic Tyr, present at the C terminus of the 2nd (ICL), which triggers STAT3 activation.
15608062 stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway has roles in migration of neural stem cells to sites of CNS injury
15598422 Mast cell function and survial are altered following in vitro infection with human immunodeficiency viruses-1 through CXCR4.
15588345 density of chemokine receptors expressed on CD4(+) T cells may be a critical parameters for the cytopathic effect of HIV strains and may have major impact on CD4 T cell depletion during HAART
15585836 HIV-1 activates major CXCR4-dependent signal transduction pathways and acts as a chemoattractant for unstimulated primary CXCR4+CD4+ T cells.
15585836 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
15585097 effect of CXCR4 activation on neuronal survival may vary depending on the ligand and/or pathways involved in cell survial cellular conditions
15549771 down-regulated during differentiation, may prove useful in studies of that process
15548717 Bone marrow strongly expresses functional stromal-derived factor (CXCL12), the ligand for CXCR4
15548713 CXCR4 receptor is frequently expressed in metastatic pancreatic tumor cells. CXCR4 not only stimulates cell motility and invasion but also promotes survival and proliferation
15542430 These results provide a plausible mechanism for HER2-mediated breast tumor metastasis and establish a functional link between HER2 and CXCR4 signaling pathways.
15540205 CXCR4 is a potential target for the attenuation of bladder cancer metastases.
15536192 constitutive endocytosis of CXCR4 in human CD34+ hematopoietic progenitor cells may be involved in the regulation of trafficking the human hematopoietic progenitor/stem cells to and in the bone marrow microenvironment
15509740 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
15492752 CXCR4 signaling mediates the establishment of lymph node metastasis in oral squamous cell carcinoma.
15486895 CXCR4 expression in neuroblastoma primary tumors is significantly correlated with the pattern of metastatic spread
15479838 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
15467730 Mechanisms of CXCR4/CXCL12-mediated prostate cancer cell migration and invasion.
15454484 CXCR4/CXCL12 axis may participate in the EBV-associated lymphomagenesis process in immunodeficient hosts.
15452229 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
15377464 Changes in the expression of CXCR4 are induced by mobilization, positively selected CD34+ cells & in vitro expansion, but this does not affect homing efficiency.
15363550 CXCR4 may be a novel regulator of head and neck squamous cell carcinoma metastatic processes
15358596 CXCL12 signaling via CXCR4 directs intestinal epithelial cell migration, barrier maturation, and restitution, consistent with an important mechanistic role for these molecules in mucosal barrier integrity and innate host defense.
15351504 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
15328206 Incubation with single chain Fv antibodies results in reduction of CXCL12-induced calcium mobilization in prostate cancer cells.
15328152 the homing of hematopoietic stem/progenitor cells is optimal when CXCR4 is incorporated in membrane lipid rafts
15327899 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
15308751 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
15279586 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
15279544 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
15258189 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
15251986 show that CXCR4, although present at the surface of a small subset of MSCs, is important for mediating specific migration of these cells to bone marrow.
15235108 CXCR4 and its ligand stromal cell-derived factor 1alpha (SDF-1alpha) induced transendothelial breast cancer cell migration through activation of the PI-3K/AKT pathway and Ca(2+)-mediated signaling.
15225616 T140 analog may act as an anti-rheumatoid arthritis agent by antagonizing CXCR4.
15215692 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
15201990 CXCR4 signaling in oral SCC cells might be involved in the diverse action of oral squamous cell carcinoma, including invasion or micrometastasis at the primary site and lymph node metastasis.
15184910 in the RD embryonal rhabdomyosarcoma cell line, PAX3-FKHR upregulates expression of the gene encoding the chemokine receptor CXCR4
15183061 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
15180966 High levels of chemokine receptor CXCR4 confer a more aggressive behavior on prostate cancer cells. CXCR4 may act not only as a homing receptor, but also as a positive regulator of tumor growth and angiogenesis.
15169555 Intracellular calcium signalling through both receptors can be measured in a single experiment upon the sequential addition of CXCR4- and CCR5-directed chemokines.
15161081 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
15128813 Pulmonary tuberculosis is associated with high level expression of CXCR4 on alveolar macrophages, which allows for entry of T cell-tropic X4 HIV-1 into alveolar macrophages.
15123627 Data suggest that the Tec family kinase ITK may regulate the ability of CXC chemokine receptor 4 to induce T cell migration.
15117454 expression significantly increased on CD4 CD45RO T cells and significantly diminished in CD4 CD45RA subset in HIV-infected adolescents; in infants no impact on expression in CD454RA CD4 subset while CXCR4 was diminished in the CD4 CD45RA subset.
15113923 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
15113900 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
15054042 SDF-1/CXCR-4 interaction is required for the survival of myeloid differentiating cells, and it also induces a block in G-CSF-induced myeloid differentiation
15048928 this study suggested that stromal cell-derived factor 1 can influence neural progenitor cells function through CXCR4 and that CXCR4 is functional on neural progenitor cells
15047829 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
15045488 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
15033938 syndecan-4/CXCR4 complex is likely a functional unit involved in SDF-1 binding
15033669 Strong CXCR4-positive nuclear staining was associated with a significantly better outcome in early-stage non-small-cell lung cancer (NSCLC).
15026622 CXCR4 is expressed in human ductal carcinoma in situ as well as in atypical ductal hyperplasia; expression at this early step of tumor development suggests CXCR4 role in providing selective advantage to such cells on their way to metastasizing carcinomas
15019705 A significant increase of stromal cell-derived factor-1alpha and CXCR4 was observed in protein extracts of idiopathic inflammatory myopathies in comparison with normal controls.
15018709 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
15014135 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
14995074 the endogenous chemokine (C-X-C motif) ligand 12 /CXCR4 signaling axis is critical for neuroblastoma cell survival and proliferation
14990729 interacts with Nef protein which targets CD4+ T cells for apoptosis
14990729 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
14990703 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
14988150 FTY720 increases CXCR4 function in hematopoietic stem cells both in vitro and in vivo
14982745 both HIV strains R5 and X4 gp120 activate intracellular signals in macrophages through CCR5 and CXCR4
14973260 first-trimester trophoblast cells express functional CXCR4/CXCL12, which may play an important role in early pregnancy such as stimulating trophoblast cell proliferation or differentiation in an autocrine manner
14764445 Important mechanistic role for CXCR4 and SDF-1/CXCL12 in regulating angiogenesis within the human intestinal mucosa.
14715575 Cross-sectional analysis of HIV-exposed, uninfected infants revealed high proportions of CXCR4-expressing cells in their cord blood, which declined at 4.5 months and increased between 9 and 15 months to levels approaching those of uninfected adults.
14694113 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
14689450 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
14688392 We observed a statistically significant decrease in the levels of surface expression of CXCR4 on myeloma cells in four consecutive apheresis collections compared with premobilization bone marrow specimens.
14684377 Epithelial CXCR4 can transduce functional signals in human intestinal epithelial cells that modulate important cAMP-mediated cellular functions.
14672331 expression of CXCR4 and CCR5 on non-cultured non-stimulated primary human trophoblast cells
14640682 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
14630801 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
14602072 Data show that the Nedd4-like E3 ubiquitin ligase AIP4 mediates ubiquitination of CXCR4 at the plasma membrane, and of the ubiquitin binding protein Hrs on endosomes.
14597738 Low oxygen concentration induces high expression of the CXCL12 receptor, CXC receptor 4 in different cell types
14595012 CXCR4 is critical to the progression of diverse brain malignancies
14592831 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
14585219 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
14576059 engagement of both CD4 and CXCR4 is required for HIV-induced shedding of L-selectin on primary resting CD4(+) T cells.
14576059 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
14567988 stromal-cell-derived factor-1alpha /CXCR4 signaling may be involved in the establishment of lymph node metastasis in oral squamous cell carcinoma via activation of both Extracellular Signal-Regulated Kinases and Akt induced by src-Family Kinases
14555820 BMECs produce and release small amounts of SDF-1 and express CXCR4 in vivo only
14505910 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
13679920 The von Hippel-Lindau tumour suppressor protein pVHL negatively regulates CXCR4 expression owing to its capacity to target hypoxia-inducible factor (HIF) for degradation under normoxic conditions
12963807 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
12960231 Macrophages are activated through CCR5- and CXCR4-mediated HIV gp120-elicited signaling pathways.
12960231 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
12953261 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
12927045 Tumors with high CXCR4 expression showed more extensive lymphatic spread than those with low CXCR4 expression, because the range and number of metastatic nodes were significantly larger in cases of high CXCR4 expression than in those with low expression.
12894851 reexpressed CXCR4 following SDF-1 removal was able to elicit integrin-dependent migration of hematopoietic progenitor cells
12882661 expression increased in individuals heterozygous for CCR5 delta 32 mutations
12882655 results confirm a role for SDF-1alpha and IL-7 in HIV-1 disease progression, and suggest that these cytokines play a role in the modulation of CXCR4
12873765 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
12873764 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
12871111 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
12864967 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
12857973 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
12853157 results provided experimental evidence for existence of close association between CD14 and HIV coreceptor CXCR4 on human monocytic cells
12845769 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
12843275 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
12834106 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
12832058 mutation at interaction site for AMD3100 influences anti-CXCR4 antibody binding and HIV-1 entry
12832058 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
12791666 PGE2 is a mediator of VEGF- and bFGF-induced CXCR4-dependent neovessel assembly in vivo and show that angiogenic effects of PGE2 require CXCR4 expression.
12783211 Factors other than alteration in SDF-1/CXCR4 chemokine system must account for marrow infiltration of neoplastic cells in B-cell chronic lymphocytic leukemia.
12775414 Changes in expression, localization, & phosphorylation/activation of Rb & E2F-1 induced by SDF-1alpha & gp120(IIIB) were analyzed in cultured rat neurons & in a human cell line expressing recombinant CXCR4. CXCR4 affects cell-cycle proteins in neurons.
12766157 SDF-1-dependent polarization of CXCR4 is promoted by leukocyte-endothelium interaction
12761880 examination of expression in prostate cancer
12726730 Mu-opioid modulates HIV-1 coreceptor expression and HIV-1 replication.
12713058 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
12705474 CXCR4 is highly expressed on muscle satellite cells.
12692554 The identification of mutations in CXCR4 in individuals with WHIM syndrome represents the first example of aberrant chemokine receptor function causing human disease.
12690099 CXCR4 is induced by NF-kappa B and has a role in breast cancer cell migration and metastasis
12651900 The specific distribution and regulation of chemokine receptors CXCR1, CXCR4, CCR5, and CCR2b in endometrial epithelium and blastocyst suggest a role for these receptors in the apposition and adhesion phases of human implantation.
12634405 some HIV-1 subtype C viruses, isolated from 29 South African patients with advanced AIDS, are able to use CCR5, CXCR4, or both CXCR4 and CCR5 for entry
12634405 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
12614324 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
12609846 L-selectin mobilized intracellular CXCR4 to significantly increase surface CXCR4 stimulation, inhibited SDF-1 induced CXCR4 internalization, increased SDF-1-induced lymphocyte adhesion and transendothelial migration.
12605695 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
12586555 HIV-1 infection of neuronal cells may involve CCR5/CXCR4 receptor
12555203 In the absence of any stimulation, human fetal astrocytes express mRNA for receptor CXCR4.
12551992 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
12519884 findings suggest that a subset of anaplastic thyroid carcinoma cells expresses functional CXCR4, which may be important in tumor cell migration and local tumor invasion
12519755 CD45 differentially regulates CXCR4-mediated chemotactic activity and MAPK activation by modulating the activities of focal adhesion components
12502809 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
12499259 Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4.
12490404 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
12488503 ubiquitination may contribute to finding of multiple MW isoforms of CXCR4
12485835 expressed in human brain tumors and is involved in glial proliferation in vitro
12433920 ligand-independent dimerization of this principal HIV-1 coreceptor
12429730 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
12429712 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
12421915 CXCR4 and motor protein nonmuscle myosin heavy chain-IIA colocalize at the leading edge of migrating T lymphocytes, together with filamentous actin and myosin light chain.
12402167 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
12393663 Role of the intracellular domains of CXCR4 in SDF-1-mediated signaling
12388552 glioma cells express CXCR4, which functions to regulate survival in part through activating pathways such as Akt
12370187 CXCR4 signaling is mediated by beta-arrestin 2
12368322 the importance of the V3 loop and the beta19 strand of an X4 gp120 glycoprotein in binding CXCR4
12368322 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
12368305 coreceptor binding domain, the V3 region of the surface envelope (SU) glycoprotein, was replaced by the V3 loop of a CD4- and CXCR4-tropic HIV-1 strain; the resulting virus, termed SIVagm3-X4mc, exclusively used CD4 and CXCR4 for cell entry
12356205 Significant increase in surface CCR5 in CD4+, CD8+, CD19+ and CD14+ cells as well as an increased percentage of CXCR3 and CXCR4 in CD14+ cells in MS patients.
12355376 P. falciparum antigens (PF-Ags) variably regulate the expression of HIV-1 coreceptors and modulate the infectability of CD4 cells by HIV-1
12354773 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
12351385 results suggest dynamic CXCR4 expression on CD34(+) stem and progenitor cells, regulating their motility and repopulation capacities
12239174 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion
12239139 CCR5-binding chemokines modulate CXCL12 (SDF-1)-induced responses of progenitor B cells in human bone marrow through heterologous desensitization of the chemokine receptor.
12218052 Protein-disulfide isomerase-mediated reduction of two disulfide bonds of HIV envelope glycoprotein 120 occurs post-binding to this protein and is required for fusion
12208881 Crosstalk between BCR/ABL oncoprotein and CXCR4 signaling through a Src family kinase in human leukemia cells.
12193696 Follicular dendritic cell-mediated up-regulation of CXCR4 expression on CD4 T cells in coculture correlates with augmented HIV-1 binding and entry into these cells and increases susceptibility of germinal center CD4 T cells to HIV infection.
12190962 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
12171912 CXCR4 expression is regulated by IL-6 or factors positively coupled to cAMP and results in SDF-1-dependent chemotaxis in central nervous system astrocytes
12163558 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
12120995 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
12093918 HIV-1 crosses M cell monolayers and infects underlying CD4(+) target cells. Transport requires both lactosyl cerebroside and CXCR4 receptors.
12034737 role of post-translational modifications of amino terminus in stromal-derived factor 1 alpha association and HIV-1 entry
12004084 leukemic Philadelphia chromosome-positive (Ph+)CD34+ cells from newly diagnosed CML patients that express the chemokine receptor CXCR4 migrate in response to stromal-derived factor-1 (SDF-1)
11994538 CXCR4 is present on the resident testicular macrophages in the interstitial space but not in the germ cell line
11983855 without functional CXCR4, morphogenesis of the hippocampal DG fails.
11967288 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11953881 CXCR4/CXCL12 expression and signalling in kidney cancer
11937572 Membrane cholesterol is essential for CXCR4 conformation and binding to SDF-1 alpha on T cells and is required by HIV on target cell membranes for infection.
11931835 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11929756 SDF-1/CXCR-4 identifies VEGF- and bFGF-regulated autocrine signaling systems that are essential regulators of endothelial cell morphogenesis and angiogenesis.
11920324 Lipopolysaccharide, lipoarabinomannan and lipoteichoic acid down-regulated the expression of CXCR4 and CCR5 on monocytes
11912162 Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone.
11884536 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11880384 mechanism of ligand recognition
11878912 the role of CD4, CXCR4, and CCR5 in HIV envelope-mediated apoptosis was examined in peripheral blood mononuclear cells
11878912 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11877445 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11876757 CCR-5 expression in thymocytes was significantly lower than that of CXCR-4 and there was no functional response. A modest increase in expression was associated with in vitro thymocyte stimulation.
11876757 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11867624 elastase-mediated proteolysis of SDF-1/CXCR4 is part of a mechanism regulating their biological functions in both homeostatic and pathologic processes
11861874 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11799176 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11752220 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11711617 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11711593 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11709091 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11698270 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11693435 Observational study of gene-disease association. (HuGE Navigator)
11689632 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11679153 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11602715 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11602639 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11595336 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11591370 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11591141 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11559423 Biological characterization and chemokine receptor usage of HIV type 1 isolates prevalent in Brazil.
11551942 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11533159 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11529558 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11517394 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11489906 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11468147 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11464139 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11462036 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11426226 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11414813 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11413305 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11408611 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11397808 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11390601 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11390582 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11356967 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11356952 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11342415 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11333905 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11313374 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11278567 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11278278 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11265761 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11264367 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11175286 Observational study of genotype prevalence. (HuGE Navigator)
11162839 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11162626 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11153675 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11141237 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11119612 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11118068 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11115360 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11086073 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11069996 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11027346 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11024154 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
11005830 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10942389 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10941932 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10903920 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10903911 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10877489 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10875613 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10864687 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10860877 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10825158 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10816381 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10801487 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10772939 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10758170 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10738970 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10704341 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10669334 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10651866 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10623764 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10602722 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10600606 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10590121 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10590105 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10585143 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10582593 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10559349 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10555208 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10544150 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10505675 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10487781 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10482576 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10449282 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10446313 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10438870 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10438703 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10430052 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10393974 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10371171 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10370370 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10364484 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10358157 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10357469 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10339592 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10329539 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10229873 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10089882 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10074122 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
10029247 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
9973525 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
9882290 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
9826718 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
9780207 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
9770524 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
9765440 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
9744279 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
9736741 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
9721247 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
9710449 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
9696823 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
9658081 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
9653130 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
9653051 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
9632631 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
9614108 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
9601645 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
9600268 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
9499115 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
9499113 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
9362541 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization
9359702 HIV-1 gp120 regulates CXCR4 utilization via cooperation between a threonine at gp120 position 123 and a N-glycan at gp120 position 262 without affecting CCR5 utilization