Property Summary

Ligand Count 23
NCBI Gene PubMed Count 1,952
PubMed Score 9942.84
PubTator Score 11179.38

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (5)

Disease Target Count Z-score Confidence
Adenocarcinoma 122 0.0 0.0
Angina, Unstable 3 0.0 0.0
Arthritis, Psoriatic 14 0.0 0.0
Arthritis, Rheumatoid 174 0.0 0.0
Barrett Esophagus 16 0.0 0.0
Behcet Syndrome 21 0.0 0.0
Breast Neoplasms 445 0.0 0.0
Cachexia 50 0.0 0.0
Carcinoma, Hepatocellular 228 0.0 0.0
Carcinoma, Non-Small-Cell Lung 107 0.0 0.0
Carcinoma, Squamous Cell 110 0.0 0.0
Cell Transformation, Neoplastic 97 0.0 0.0
Cholestasis 155 0.0 0.0
Colitis, Ulcerative 59 0.0 0.0
Colorectal Neoplasms 243 0.0 0.0
Down syndrome 499 0.0 0.0
Edema 81 0.0 0.0
Endometrial Neoplasms 55 0.0 0.0
Esophagitis, Peptic 1 0.0 0.0
Eye Infections, Bacterial 2 0.0 0.0
Fatty Liver 70 0.0 0.0
Gastroesophageal Reflux 4 0.0 0.0
Glomerulonephritis 46 0.0 0.0
Hepatitis, Alcoholic 5 0.0 0.0
Hepatolenticular Degeneration 24 0.0 0.0
Hyperalgesia 83 0.0 0.0
Hypertension, Pulmonary 37 0.0 0.0
Inflammation 120 0.0 0.0
Keratitis 62 0.0 0.0
Leishmaniasis, Cutaneous 8 0.0 0.0
Leishmaniasis, Visceral 13 0.0 0.0
Lichenoid Eruptions 2 0.0 0.0
Mesothelioma, Malignant 105 0.0 0.0
Neuralgia, Postherpetic 3 0.0 0.0
Ovarian Neoplasms 102 0.0 0.0
Pain, Intractable 1 0.0 0.0
Pancreatic Neoplasms 85 0.0 0.0
Pemphigoid, Bullous 1 0.0 0.0
Pneumonia, Pneumococcal 6 0.0 0.0
Prostatic Neoplasms 495 0.0 0.0
Pulmonary Disease, Chronic Obstructive 31 0.0 0.0
Pulmonary Fibrosis 106 0.0 0.0
Reperfusion Injury 86 0.0 0.0
Staphylococcal Infections 5 0.0 0.0
Stomach Neoplasms 300 0.0 0.0
Thyroid Neoplasms 34 0.0 0.0
Tobacco Use Disorder 12 0.0 0.0
Urinary Bladder Neoplasms 114 0.0 0.0
glioblastoma 5792 0.0 1.0897479297674E-4
Disease Target Count Z-score Confidence
Lung disease 142 6.454 3.2
Cancer 2499 6.092 3.0
Asthma 385 5.861 2.9
Arthritis 290 5.679 2.8
Inflammatory bowel disease 151 5.366 2.7
Gastritis 47 5.131 2.6
Chorioamnionitis 14 4.946 2.5
Atherosclerosis 291 4.94 2.5
Dermatitis 157 4.885 2.4
Mastitis 48 4.848 2.4
Eye disease 62 4.648 2.3
Common cold 67 4.462 2.2
Endometriosis 540 4.409 2.2
Bacterial vaginosis 15 4.379 2.2
Bronchitis 43 4.35 2.2
Hypersensitivity reaction type II disease 253 4.344 2.2
Meningitis 67 4.287 2.1
Coronary artery disease 268 4.22 2.1
Bronchiectasis 64 4.206 2.1
Kidney disease 430 4.152 2.1
Peptic ulcer disease 11 4.139 2.1
Allergic rhinitis 94 4.082 2.0
Vasculitis 80 4.077 2.0
Pancreatitis 123 4.066 2.0
diabetes mellitus 1728 4.054 2.0
Liver disease 237 4.051 2.0
Influenza 142 4.024 2.0
Obesity 678 4.022 2.0
Heart disease 306 3.964 2.0
Diarrhea 253 3.96 2.0
Allergic hypersensitivity disease 126 3.939 2.0
Human immunodeficiency virus infectious disease 138 3.936 2.0
Leukopenia 72 3.915 2.0
Acute cystitis 35 3.914 2.0
Perinatal necrotizing enterocolitis 21 3.892 1.9
Sinusitis 65 3.872 1.9
Peritonitis 43 3.863 1.9
Prostatitis 18 3.844 1.9
Endometritis 21 3.759 1.9
Hypertension 396 3.668 1.8
Otitis Media 52 3.665 1.8
Acne 52 3.592 1.8
Cerebrovascular disease 238 3.377 1.7
Hypereosinophilic syndrome 71 3.366 1.7
Bacteriuria 8 3.341 1.7
Gingivitis 29 3.318 1.7
Brain disease 96 3.251 1.6
Severe acute respiratory syndrome 27 3.241 1.6
Chlamydia 21 3.194 1.6
Malaria 160 3.172 1.6
Salmonellosis 42 3.137 1.6
Multiple Sclerosis 540 3.123 1.6
Anemia 365 3.085 1.5
sarcoidosis 370 3.04 1.5
Infertility 188 3.005 1.5
Funisitis 7 3.002 1.5

Expression

  Differential Expression (33)

Disease log2 FC p
cystic fibrosis 4.705 8.0e-05
periodontitis 1.300 8.7e-14
psoriasis 3.900 1.3e-05
tuberculosis -2.300 1.3e-03
Rheumatoid arthritis 3.700 6.9e-04
Bipolar Disorder 1.238 4.4e-02
glioblastoma 2.500 1.1e-04
malignant mesothelioma -5.400 1.0e-08
active ulcerative colitis 2.712 7.9e-03
acute myeloid leukemia 3.600 8.3e-04
adrenocortical adenoma -1.669 4.4e-04
adult high grade glioma 2.300 8.8e-04
Astrocytoma, Pilocytic 1.800 2.9e-03
atypical teratoid / rhabdoid tumor 1.400 5.1e-03
Barrett's esophagus 1.800 1.9e-02
chronic lymphosyte leukemia -1.100 3.2e-04
colon cancer 2.400 1.5e-02
ductal carcinoma in situ 2.600 1.4e-02
ependymoma 2.600 8.0e-05
esophageal adenocarcinoma 2.400 1.8e-02
gastric cancer -2.500 3.5e-02
head and neck cancer 1.900 3.2e-02
hepatocellular carcinoma -3.200 3.6e-03
interstitial cystitis 1.800 2.0e-03
lung cancer -3.700 8.5e-06
lung carcinoma -2.300 1.3e-06
mucosa-associated lymphoid tissue lympho... 1.561 1.8e-02
non primary Sjogren syndrome sicca -1.400 2.6e-02
ovarian cancer 1.600 4.0e-03
pancreatic cancer 2.800 4.8e-05
pancreatic ductal adenocarcinoma liver m... 1.363 2.3e-02
pituitary cancer -1.400 2.0e-02
remitted schizophrenia patient 1.600 2.8e-02

Protein-protein Interaction (2)

PDB (12)

Gene RIF (1982)

AA Sequence

MTSKLAVALLAAFLISAALCEGAVLPRSAKELRCQCIKTYSKPFHPKFIKELRVIESGPHCANTEIIVKL      1 - 70
SDGRELCLDPKENWVQRVVEKFLKRAENS                                              71 - 99
//

Text Mined References (1955)

PMID Year Title