Property Summary

NCBI Gene PubMed Count 18
PubMed Score 11.86
PubTator Score 9.07

Knowledge Summary


No data available


  Disease (2)

Disease Target Count
Autism Spectrum Disorders 4
Disease Target Count P-value
ovarian cancer 8491 2.8e-06
Multiple myeloma 1327 1.1e-03
lung cancer 4473 1.6e-02


  Differential Expression (3)

Disease log2 FC p
Multiple myeloma 1.132 1.1e-03
lung cancer 1.300 1.6e-02
ovarian cancer 2.000 2.8e-06


Accession Q9H467 D3DR88 Q9BWG8
Symbols C10orf66


  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

Gene RIF (9)

26023733 Results suggest that decreased expression of CUEDC2 contributes to tumor growth in lung adenocarcinoma, leading to a poor clinical outcome.
24882011 CUEDC2 plays a crucial role in modulating macrophage function and is associated with both colitis and colon tumorigenesis.
24125838 High CUEDC2 sensitizes chronic myeloid leukemic cells to imatinib treatment.
23776205 In response to UV irradiation, CUEDC2 undergoes ERK1/2-dependent phosphorylation and ubiquitin-dependent degradation, leading to APC/C(Cdh1)-mediated cyclin A destruction, cyclin-dependent kinase 2 inactivation, and G1 arrest.
22084247 a new biological activity for CUEDC2 as the regulator of JAK1/STAT3 signaling and the mechanism by which SOCS3 has been linked to suppression of the JAK/STAT pathway
21743465 CUEDC2 is a cell-cycle regulator that promotes spindle checkpoint inactivation and releases APC/C from checkpoint inhibition. CUEDC2 is phosphorylated by Cdk1 during mitosis.
21572428 key factor in endocrine resistance in breast cancer
17347654 These results identify a key post-translational mechanism that controls progesterone receptor protein levels and for the first time provide an important insight into the function of CUEDC2 in breast cancer proliferation.
16385451 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence

ARKYRFH                                                                   281 - 287

Text Mined References (21)

PMID Year Title
26023733 2015 CUEDC2 down-regulation is associated with tumor growth and poor prognosis in lung adenocarcinoma.
25534755 2015 A genome-wide association study of autism using the Simons Simplex Collection: Does reducing phenotypic heterogeneity in autism increase genetic homogeneity?
24882011 2014 Dysregulation of the miR-324-5p-CUEDC2 axis leads to macrophage dysfunction and is associated with colon cancer.
24685480 2014 CUEDC2 interacts with heat shock protein 70 and negatively regulates its chaperone activity.
24125838 2013 CUEDC2 sensitizes chronic myeloid leukemic cells to imatinib treatment.
23776205 2013 Phosphorylation-triggered CUEDC2 degradation promotes UV-induced G1 arrest through APC/C(Cdh1) regulation.
23535732 2013 Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22084247 2012 CUEDC2 (CUE domain-containing 2) and SOCS3 (suppressors of cytokine signaling 3) cooperate to negatively regulate Janus kinase 1/signal transducers and activators of transcription 3 signaling.
21743465 2011 Cdk1-phosphorylated CUEDC2 promotes spindle checkpoint inactivation and chromosomal instability.
21572428 2011 Elevated expression of CUEDC2 protein confers endocrine resistance in breast cancer.
21269460 2011 Initial characterization of the human central proteome.
20068231 2010 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
17347654 2007 CUE domain containing 2 regulates degradation of progesterone receptor by ubiquitin-proteasome.
16385451 2006 A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
16341674 2005 Transcriptome analysis of human gastric cancer.
16189514 2005 Towards a proteome-scale map of the human protein-protein interaction network.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15164054 2004 The DNA sequence and comparative analysis of human chromosome 10.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.