| Tbio | Cathepsin W |
May have a specific function in the mechanism or regulation of T-cell cytolytic activity.
The protein encoded by this gene, a member of the peptidase C1 family, is a cysteine proteinase that may have a specific function in the mechanism or regulation of T-cell cytolytic activity. The encoded protein is found associated with the membrane inside the endoplasmic reticulum of natural killer and cytotoxic T-cells. Expression of this gene is up-regulated by interleukin-2. [provided by RefSeq, Jul 2008]
The protein encoded by this gene, a member of the peptidase C1 family, is a cysteine proteinase that may have a specific function in the mechanism or regulation of T-cell cytolytic activity. The encoded protein is found associated with the membrane inside the endoplasmic reticulum of natural killer and cytotoxic T-cells. Expression of this gene is up-regulated by interleukin-2. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 1.1e-17 |
| lung carcinoma | 2843 | 5.7e-10 |
| osteosarcoma | 7950 | 7.1e-06 |
| tuberculosis | 2010 | 3.5e-05 |
| cutaneous lupus erythematosus | 1057 | 5.0e-03 |
| acute myeloid leukemia | 783 | 2.6e-02 |
| Disease | log2 FC | p |
|---|---|---|
| acute myeloid leukemia | 1.600 | 2.6e-02 |
| cutaneous lupus erythematosus | 1.900 | 5.0e-03 |
| lung carcinoma | -1.400 | 5.7e-10 |
| non-small cell lung cancer | -1.320 | 1.1e-17 |
| osteosarcoma | -3.716 | 7.1e-06 |
| tuberculosis | 1.100 | 3.5e-05 |
MALTAHPSCLLALLVAGLAQGIRGPLRAQDLGPQPLELKEAFKLFQIQFNRSYLSPEEHAHRLDIFAHNL 1 - 70 AQAQRLQEEDLGTAEFGVTPFSDLTEEEFGQLYGYRRAAGGVPSMGREIRSEEPEESVPFSCDWRKVASA 71 - 140 ISPIKDQKNCNCCWAMAAAGNIETLWRISFWDFVDVSVQELLDCGRCGDGCHGGFVWDAFITVLNNSGLA 141 - 210 SEKDYPFQGKVRAHRCHPKKYQKVAWIQDFIMLQNNEHRIAQYLATYGPITVTINMKPLQLYRKGVIKAT 211 - 280 PTTCDPQLVDHSVLLVGFGSVKSEEGIWAETVSSQSQPQPPHPTPYWILKNSWGAQWGEKGYFRLHRGSN 281 - 350 TCGITKFPLTARVQKPDMKPRVSCPP 351 - 376 //
