| Tchem | Cathepsin K |
The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013]
Comments
Property Summary
| Ligand Count | 1,400 |
| NCBI Gene PubMed Count | 153 |
| PubMed Score | 936.03 |
| PubTator Score | 658.88 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Pycnodysostosis | 5 | 7.22 | 3.6 |
| glioblastoma | 5792 | 0.0 | 3.37205944107627E-4 |
| Disease | Target Count |
|---|---|
| Chronic hepatitis C | 12 |
| Disease | Target Count | P-value |
|---|---|---|
| Duchenne muscular dystrophy | 601 | 6.4e-11 |
| Astrocytoma, Pilocytic | 3081 | 1.2e-08 |
| cystic fibrosis | 1696 | 2.2e-06 |
| Breast cancer | 3578 | 2.4e-06 |
| ulcerative colitis | 1819 | 2.9e-05 |
| primary pancreatic ductal adenocarcinoma | 1109 | 3.1e-05 |
| acute quadriplegic myopathy | 1158 | 6.2e-05 |
| ovarian cancer | 8520 | 8.5e-05 |
| tuberculosis and treatment for 6 months | 409 | 3.0e-04 |
| primary Sjogren syndrome | 735 | 6.7e-04 |
| adult high grade glioma | 3801 | 1.2e-03 |
| Atopic dermatitis | 952 | 1.4e-03 |
| group 3 medulloblastoma | 4104 | 2.5e-03 |
| gastric carcinoma | 807 | 2.8e-03 |
| diabetes mellitus | 1728 | 6.3e-03 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 1.1e-02 |
| pancreatic cancer | 2398 | 1.6e-02 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 3.6e-02 |
| osteosarcoma | 7950 | 3.7e-02 |
| Disease | log2 FC | p |
|---|---|---|
| glioblastoma | 1.200 | 3.4e-04 |
| acute quadriplegic myopathy | 1.266 | 6.2e-05 |
| adult high grade glioma | 1.100 | 1.2e-03 |
| Astrocytoma, Pilocytic | 2.300 | 1.2e-08 |
| Atopic dermatitis | -1.800 | 1.4e-03 |
| Breast cancer | 1.700 | 2.4e-06 |
| cystic fibrosis | 1.888 | 2.2e-06 |
| diabetes mellitus | -1.300 | 6.3e-03 |
| Duchenne muscular dystrophy | 1.551 | 6.4e-11 |
| gastric carcinoma | 2.400 | 2.8e-03 |
| group 3 medulloblastoma | 1.200 | 2.5e-03 |
| intraductal papillary-mucinous adenoma (... | -1.700 | 1.1e-02 |
| intraductal papillary-mucinous carcinoma... | -1.500 | 3.6e-02 |
| osteosarcoma | 2.102 | 3.7e-02 |
| ovarian cancer | -2.200 | 8.5e-05 |
| pancreatic cancer | 1.100 | 1.6e-02 |
| primary pancreatic ductal adenocarcinoma | 3.454 | 3.1e-05 |
| primary Sjogren syndrome | 1.300 | 6.7e-04 |
| tuberculosis and treatment for 6 months | 1.300 | 3.0e-04 |
| ulcerative colitis | 2.500 | 2.9e-05 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG |
boceprevir
pIC50 7.40
telaprevir
pIC50 6.20
CHEMBL59277
pIC50 6.00
CHEMBL100428
pKi 6.00
CHEMBL428390
pKi 6.00
CHEMBL86088
pIC50 6.00
CHEMBL3649408
pIC50 6.00
CHEMBL1209376
pIC50 6.00
CHEMBL1079099
pIC50 6.00
CHEMBL1079101
pIC50 6.00
CHEMBL482218
pKi 6.00
CHEMBL1672430
pIC50 6.00
CHEMBL557455
pIC50 6.00
CHEMBL1079013
pIC50 6.00
CHEMBL262697
pIC50 6.00
CHEMBL218522
pIC50 6.00
CHEMBL3143405
pKi 6.00
CHEMBL202622
pIC50 6.00
CHEMBL3261919
pIC50 6.00
CHEMBL31674
pKi 6.01
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHT 1 - 70 YELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCW 71 - 140 AFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESC 141 - 210 MYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLA 211 - 280 VGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM 281 - 329 //
