CTSK
Cathepsin K
Protein Summary
Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013]
- ENST00000271651
- ENSP00000271651
- ENSG00000143387
- CTSO
- CTSO2
- CTSO
- PKND
- PYCD
- CTS02
- CTSO1
- CTSO2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.92 | ||
biological term | 0.84 | ||
cellular component | 0.8 | ||
drug | 0.79 | ||
disease perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1493.27 (req: < 5)
Gene RIFs: 151 (req: <= 3)
Antibodies: 548 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1493.27 (req: >= 5)
Gene RIFs: 151 (req: > 3)
Antibodies: 548 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 1459
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2