| Tchem | Cathepsin K |
The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013]
Comments
Property Summary
| NCBI Gene PubMed Count | 144 |
| Grant Count | 159 |
| R01 Count | 112 |
| Funding | $13,132,011.15 |
| PubMed Score | 869.69 |
| PubTator Score | 658.88 |
| Disease | log2 FC | p |
|---|---|---|
| glioblastoma | 1.400 | 0.034 |
| osteosarcoma | 2.102 | 0.037 |
| medulloblastoma | 1.400 | 0.000 |
| cystic fibrosis | 1.888 | 0.000 |
| Duchenne muscular dystrophy | 1.551 | 0.000 |
| acute quadriplegic myopathy | 1.266 | 0.000 |
| Atopic dermatitis | -1.800 | 0.001 |
| tuberculosis and treatment for 6 months | 1.300 | 0.000 |
| primary pancreatic ductal adenocarcinoma | 3.454 | 0.000 |
| intraductal papillary-mucinous adenoma (... | -1.700 | 0.011 |
| intraductal papillary-mucinous carcinoma... | -1.500 | 0.036 |
| pancreatic cancer | 3.400 | 0.000 |
| diabetes mellitus | -1.300 | 0.006 |
| adult high grade glioma | 1.100 | 0.001 |
| pilocytic astrocytoma | 2.300 | 0.000 |
| primary Sjogren syndrome | 1.300 | 0.001 |
| Breast cancer | 1.700 | 0.000 |
| gastric carcinoma | 2.400 | 0.003 |
| ulcerative colitis | 2.500 | 0.000 |
| ovarian cancer | -2.200 | 0.000 |
CHEMBL59277
pIC50 6.00
CHEMBL100428
pKi 6.00
CHEMBL428390
pKi 6.00
CHEMBL86088
pIC50 6.00
CHEMBL3649408
pIC50 6.00
CHEMBL1209376
pIC50 6.00
CHEMBL1079099
pIC50 6.00
CHEMBL1079101
pIC50 6.00
CHEMBL482218
pKi 6.00
CHEMBL1672430
pIC50 6.00
CHEMBL557455
pIC50 6.00
CHEMBL1079013
pIC50 6.00
CHEMBL262697
pIC50 6.00
CHEMBL218522
pIC50 6.00
CHEMBL3143405
pKi 6.00
CHEMBL202622
pIC50 6.00
CHEMBL3261919
pIC50 6.00
CHEMBL31674
pKi 6.01
CHEMBL195000
pIC50 6.01
CHEMBL1077366
pIC50 6.01
| PMID | Text |
|---|---|
| 26302400 | elevated levels of CatK are closely associated with the presence of chronic heart failure and that the measurement of circulating CatK provides a noninvasive method of documenting and monitoring the extent of chronic heart failure |
| 26241216 | increased expression and activation in osteoarthritis cartilage |
| 26219353 | Matrix-metalloproteinase-9 is cleaved and activated by cathepsin K. |
| 25809793 | SDF-1alpha is involved in homing of CXCR4+ GSLCs and leukocytes and that cathepsin K and osteopontin are involved in the migration of GSLCs out of the niches |
| 25725806 | Sequence analysis of the patient's CTSK gene revealed homozygosity for a missense mutation (c.746T>C) in exon 6, which leads to amino change (p.Ile249Thr) in the mature CTSK protein |
| 25662720 | There is an increase in levels of CATK in type 1 Gaucher patients compared to the control group. In the patient group, CATK showed higher levels in patients with bone damage compared to those without it. |
| 25626674 | The study determined almost identical substrate specificities for cysteine cathepsins K, L and S. |
| 25558848 | Cathepsins in Rotator Cuff Tendinopathy: Identification in Human Chronic Tears and Temporal Induction in a Rat Model. |
| 25422423 | one cathepsin K molecule binds to collagen-bound glycosaminoglycans at the gap region and recruits a second protease molecule that provides an unfolding and cleavage mechanism for triple helical collagen |
| 25356585 | The presence of high levels of inactive proforms of cathepsin K in GBM tissues and cells indicate that in GBM the proteolytic/collagenolytic role is not its primary function but it plays rather a different yet unknown role. |
| More... |
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHT 1 - 70 YELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCW 71 - 140 AFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESC 141 - 210 MYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLA 211 - 280 VGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM 281 - 329 //
| PMID | Year | Title |
|---|---|---|
| 26302400 | 2015 | Increased Circulating Cathepsin K in Patients with Chronic Heart Failure. |
| 26241216 | 2016 | Increased expression and activation of cathepsin K in human osteoarthritic cartilage and synovial tissues. |
| 26219353 | 2015 | Matrix-metalloproteinase-9 is cleaved and activated by cathepsin K. |
| 25809793 | 2015 | CD133+ and Nestin+ Glioma Stem-Like Cells Reside Around CD31+ Arterioles in Niches that Express SDF-1?, CXCR4, Osteopontin and Cathepsin K. |
| 25731711 | 2015 | Dental Abnormalities Caused by Novel Compound Heterozygous CTSK Mutations. |
| 25725806 | 2015 | A Mutation in CTSK Gene in an Autosomal Recessive Pycnodysostosis Family of Chinese Origin. |
| 25662720 | 2015 | [Cathepsin K as a biomarker of bone involvement in type 1 Gaucher disease]. |
| 25626674 | 2015 | Fast profiling of protease specificity reveals similar substrate specificities for cathepsins K, L and S. |
| 25558848 | 2015 | Cathepsins in Rotator Cuff Tendinopathy: Identification in Human Chronic Tears and Temporal Induction in a Rat Model. |
| 25422423 | 2014 | Structural basis of collagen fiber degradation by cathepsin K. |
| More... |
