Tbio CTAG2 Cancer/testis antigen 2

Protein Summary

Description

This gene encodes an autoimmunogenic tumor antigen that belongs to the ESO/LAGE family of cancer-testis antigens. This protein is expressed in a wide array of cancers including melanoma, breast cancer, bladder cancer and prostate cancer. This protein is also expressed in normal testis tissue. An alternative open reading frame product of this gene has been described in PMID:10399963. This alternate protein, termed CAMEL, is a tumor antigen that is recognized by melanoma-specific cytotoxic T-lymphocytes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Uniprot Accession IDs

• O75638
• O75637
• Q0VIL6
• Q14CD6
• Q2Z1N4
• Q9BU80
• Q9UJ89
• Q9Y479
• CT2

Gene Name

• CTAG2

Ensembl ID

• ENST00000247306
• ENSP00000247306
• ENSG00000126890
• ENST00000369585
• ENSP00000358598

Symbol

• ESO2
• LAGE1
• CT2
• ESO2
• CAMEL
• CT6.2
• CT6.2a
• CT6.2b
• LAGE-1
• LAGE2B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.59
cell type or tissue	0.58
tissue	0.47
tissue sample	0.47
biological term	0.46

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.08   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 140   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.08   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0