| Tdark | Cysteine/serine-rich nuclear protein 3 |
Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity. Plays a role in apoptosis (By similarity).
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Abortion, Spontaneous | 109 | 0.0 | 0.0 |
| Substance-Related Disorders | 115 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Spontaneous abortion | 113 |
| Disease | Target Count | P-value |
|---|---|---|
| Breast cancer | 3578 | 1.7e-25 |
| lung carcinoma | 2843 | 1.4e-20 |
| breast carcinoma | 1638 | 5.5e-19 |
| oligodendroglioma | 2850 | 1.0e-11 |
| malignant mesothelioma | 3232 | 9.4e-08 |
| pituitary cancer | 1972 | 1.1e-06 |
| glioblastoma | 5792 | 1.6e-05 |
| ovarian cancer | 8520 | 4.4e-05 |
| Astrocytoma, Pilocytic | 3081 | 6.5e-04 |
| lung cancer | 4740 | 6.6e-04 |
| adult high grade glioma | 3801 | 4.1e-03 |
| Pick disease | 1894 | 5.3e-03 |
| ependymoma | 4679 | 6.4e-03 |
| astrocytic glioma | 2597 | 9.8e-03 |
| medulloblastoma, large-cell | 6241 | 1.6e-02 |
| aldosterone-producing adenoma | 665 | 1.6e-02 |
| progressive supranuclear palsy | 676 | 1.6e-02 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.7e-02 |
| ductal carcinoma in situ | 1745 | 2.1e-02 |
| invasive ductal carcinoma | 2951 | 3.6e-02 |
| group 4 medulloblastoma | 1855 | 3.8e-02 |
| osteosarcoma | 7950 | 4.3e-02 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 4.5e-02 |
| Alzheimer's disease | 658 | 5.0e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| LEOPARD syndrome | 20 | 4.235 | 2.1 |
| Arrhythmogenic right ventricular cardiomyopathy | 30 | 3.507 | 1.8 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -2.100 | 4.1e-03 |
| aldosterone-producing adenoma | -1.243 | 1.6e-02 |
| Alzheimer's disease | 1.400 | 5.0e-02 |
| astrocytic glioma | -1.500 | 9.8e-03 |
| Astrocytoma, Pilocytic | -1.400 | 6.5e-04 |
| atypical teratoid / rhabdoid tumor | -1.900 | 1.7e-02 |
| Breast cancer | -1.500 | 1.7e-25 |
| breast carcinoma | -1.200 | 5.5e-19 |
| ductal carcinoma in situ | -1.100 | 2.1e-02 |
| ependymoma | -1.400 | 6.4e-03 |
| glioblastoma | -1.600 | 1.6e-05 |
| group 4 medulloblastoma | -1.300 | 3.8e-02 |
| intraductal papillary-mucinous carcinoma... | -1.500 | 4.5e-02 |
| invasive ductal carcinoma | -1.200 | 3.6e-02 |
| lung cancer | 1.600 | 6.6e-04 |
| lung carcinoma | 2.900 | 1.4e-20 |
| malignant mesothelioma | -2.600 | 9.4e-08 |
| medulloblastoma, large-cell | -1.900 | 1.6e-02 |
| oligodendroglioma | -1.300 | 1.0e-11 |
| osteosarcoma | 1.006 | 4.3e-02 |
| ovarian cancer | 1.300 | 4.4e-05 |
| Pick disease | 1.900 | 5.3e-03 |
| pituitary cancer | 1.500 | 1.1e-06 |
| progressive supranuclear palsy | 1.700 | 1.6e-02 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG |
MSGILKRKFEEVDGSSPCSSVRESDDEVSSSESADSGDSVNPSTSSHFTPSSILKREKRLRTKNVHFSCV 1 - 70 TVYYFTRRQGFTSVPSQGGSTLGMSSRHNSVRQYTLGEFAREQERLHREMLREHLREEKLNSLKLKMTKN 71 - 140 GTVESEEASTLTLDDISDDDIDLDNTEVDEYFFLQPLPTKKRRALLRASGVKKIDVEEKHELRAIRLSRE 141 - 210 DCGCDCRVFCDPDTCTCSLAGIKCQVDRMSFPCGCTKEGCSNTAGRIEFNPIRVRTHFLHTIMKLELEKN 211 - 280 REQQIPTLNGCHSEISAHSSSMGPVAHSVEYSIADSFEIETEPQAAVLHLQSAEELDCQGEEEEEEEDGS 281 - 350 SFCSGVTDSSTQSLAPSESDEEEEEEEEEEEEEDDDDDKGDGFVEGLGTHAEVVPLPSVLCYSDGTAVHE 351 - 420 SHAKNASFYANSSTLYYQIDSHIPGTPNQISENYSERDTVKNGTLSLVPYTMTPEQFVDYARQAEEAYGA 421 - 490 SHYPAANPSVIVCCSSSENDSGVPCNSLYPEHRSNHPQVEFHSYLKGPSQEGFVSALNGDSHISEHPAEN 491 - 560 SLSLAEKSILHEECIKSPVVETVPV 561 - 585 //
