| Tdark | Cysteine/serine-rich nuclear protein 3 |
Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity. Plays a role in apoptosis (By similarity).
Comments
| Disease | Target Count |
|---|---|
| Spontaneous abortion | 108 |
| Substance-Related Disorders | 114 |
| Disease | Target Count | P-value |
|---|---|---|
| breast carcinoma | 1614 | 2.4e-22 |
| Breast cancer | 3098 | 3.8e-22 |
| lung carcinoma | 2844 | 1.4e-20 |
| oligodendroglioma | 2849 | 2.5e-10 |
| malignant mesothelioma | 3163 | 9.4e-08 |
| lung cancer | 4473 | 7.0e-07 |
| pituitary cancer | 1972 | 1.1e-06 |
| ovarian cancer | 8491 | 4.4e-05 |
| sonic hedgehog group medulloblastoma | 1482 | 2.0e-04 |
| glioblastoma | 5572 | 7.3e-04 |
| pediatric high grade glioma | 2712 | 1.7e-03 |
| invasive ductal carcinoma | 2950 | 2.4e-03 |
| osteosarcoma | 7933 | 3.6e-03 |
| pilocytic astrocytoma | 3086 | 3.6e-03 |
| Pick disease | 1893 | 5.3e-03 |
| atypical teratoid / rhabdoid tumor | 4369 | 5.3e-03 |
| ependymoma | 2514 | 6.4e-03 |
| ductal carcinoma in situ | 1745 | 8.1e-03 |
| aldosterone-producing adenoma | 664 | 1.6e-02 |
| progressive supranuclear palsy | 674 | 1.6e-02 |
| medulloblastoma, large-cell | 6234 | 1.9e-02 |
| astrocytic glioma | 2241 | 2.1e-02 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2988 | 4.5e-02 |
| Alzheimer's disease | 644 | 5.0e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| LEOPARD Syndrome | 20 | 4.513 | 2.3 |
| Arrhythmogenic right ventricular cardiomyopathy | 27 | 3.78 | 1.9 |
| Disease | log2 FC | p |
|---|---|---|
| malignant mesothelioma | -2.600 | 9.4e-08 |
| astrocytic glioma | -1.600 | 2.1e-02 |
| ependymoma | -1.400 | 6.4e-03 |
| glioblastoma | -3.000 | 7.3e-04 |
| oligodendroglioma | -1.500 | 2.5e-10 |
| osteosarcoma | 2.575 | 3.6e-03 |
| sonic hedgehog group medulloblastoma | -2.300 | 2.0e-04 |
| atypical teratoid / rhabdoid tumor | -3.400 | 5.3e-03 |
| medulloblastoma, large-cell | -2.100 | 1.9e-02 |
| intraductal papillary-mucinous carcinoma... | -1.500 | 4.5e-02 |
| lung cancer | 4.400 | 7.0e-07 |
| pediatric high grade glioma | -2.200 | 1.7e-03 |
| pilocytic astrocytoma | -1.500 | 3.6e-03 |
| aldosterone-producing adenoma | -1.243 | 1.6e-02 |
| Breast cancer | -3.100 | 3.8e-22 |
| lung carcinoma | 2.900 | 1.4e-20 |
| breast carcinoma | -1.800 | 2.4e-22 |
| Alzheimer's disease | 1.400 | 5.0e-02 |
| Pick disease | 1.900 | 5.3e-03 |
| progressive supranuclear palsy | 1.700 | 1.6e-02 |
| ductal carcinoma in situ | -1.300 | 8.1e-03 |
| invasive ductal carcinoma | -2.300 | 2.4e-03 |
| ovarian cancer | 1.300 | 4.4e-05 |
| pituitary cancer | 1.500 | 1.1e-06 |
MSGILKRKFEEVDGSSPCSSVRESDDEVSSSESADSGDSVNPSTSSHFTPSSILKREKRLRTKNVHFSCV 1 - 70 TVYYFTRRQGFTSVPSQGGSTLGMSSRHNSVRQYTLGEFAREQERLHREMLREHLREEKLNSLKLKMTKN 71 - 140 GTVESEEASTLTLDDISDDDIDLDNTEVDEYFFLQPLPTKKRRALLRASGVKKIDVEEKHELRAIRLSRE 141 - 210 DCGCDCRVFCDPDTCTCSLAGIKCQVDRMSFPCGCTKEGCSNTAGRIEFNPIRVRTHFLHTIMKLELEKN 211 - 280 REQQIPTLNGCHSEISAHSSSMGPVAHSVEYSIADSFEIETEPQAAVLHLQSAEELDCQGEEEEEEEDGS 281 - 350 SFCSGVTDSSTQSLAPSESDEEEEEEEEEEEEEDDDDDKGDGFVEGLGTHAEVVPLPSVLCYSDGTAVHE 351 - 420 SHAKNASFYANSSTLYYQIDSHIPGTPNQISENYSERDTVKNGTLSLVPYTMTPEQFVDYARQAEEAYGA 421 - 490 SHYPAANPSVIVCCSSSENDSGVPCNSLYPEHRSNHPQVEFHSYLKGPSQEGFVSALNGDSHISEHPAEN 491 - 560 SLSLAEKSILHEECIKSPVVETVPV 561 - 585 //
| PMID | Year | Title | |
|---|---|---|---|
| 24688116 | 2014 | Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age. | |
| 20468071 | 2010 | Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. | |
| 19401682 | 2010 | High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. | |
| 19389623 | 2009 | Docking motif-guided mapping of the interactome of protein phosphatase-1. | |
| 18029348 | 2008 | Toward a confocal subcellular atlas of the human proteome. | |
| 17726538 | 2007 | Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP). | |
| 16959974 | 2006 | The consensus coding sequences of human breast and colorectal cancers. | |
| 16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. | |
| 15815621 | 2005 | Generation and annotation of the DNA sequences of human chromosomes 2 and 4. | |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
